2023
A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better
Djureinovic D, Weiss S, Krykbaeva I, Qu R, Vathiotis I, Moutafi M, Zhang L, Perdigoto A, Wei W, Anderson G, Damsky W, Hurwitz M, Johnson B, Schoenfeld D, Mahajan A, Hsu F, Miller-Jensen K, Kluger Y, Sznol M, Kaech S, Bosenberg M, Jilaveanu L, Kluger H. A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better. Molecular Cancer 2023, 22: 182. PMID: 37964379, PMCID: PMC10644655, DOI: 10.1186/s12943-023-01884-x.Peer-Reviewed Original ResearchConceptsStable diseasePartial responseMacrophage populationsThree-drug regimenUnconfirmed partial responsePhase I trialLimited treatment optionsMonocyte/macrophage populationNon-classical monocytesMurine melanoma modelTreatment-related changesResultsThirteen patientsWorse survivalI trialInflammatory tumorPatient populationTreatment optionsImmune cellsDisease progressionMurine studiesPreclinical modelsResistant melanomaAntigen presentationMurine modelCyTOF analysis
2013
Input–Output Functions of Vestibular Afferent Responses to Air-Conducted Clicks in Rats
Zhu H, Tang X, Wei W, Maklad A, Mustain W, Rabbitt R, Highstein S, Allison J, Zhou W. Input–Output Functions of Vestibular Afferent Responses to Air-Conducted Clicks in Rats. Journal Of The Association For Research In Otolaryngology 2013, 15: 73-86. PMID: 24297262, PMCID: PMC3901862, DOI: 10.1007/s10162-013-0428-6.Peer-Reviewed Original ResearchConceptsVestibular end organsAnterior canalEnd organsHorizontal canalVEMP testVestibular afferentsPosterior canalOrgan afferentsSemicircular canalsAir-conducted clicksVestibular myogenic potentialsDB SLSprague-Dawley ratsVestibular afferent responsesSingle-unit recordingsIntra-axonal recordingsSensitive afferentsSaccular functionSternocleidomastoid muscleVestibular functionAcoustic click stimuliCanal cristaClinical assessmentMyogenic potentialsExtraocular muscles
2011
Click-evoked responses in vestibular afferents in rats
Zhu H, Tang X, Wei W, Mustain W, Xu Y, Zhou W. Click-evoked responses in vestibular afferents in rats. Journal Of Neurophysiology 2011, 106: 754-763. PMID: 21613592, DOI: 10.1152/jn.00003.2011.Peer-Reviewed Original ResearchConceptsVestibular end organsVestibular afferentsAnterior canalPosterior canalHorizontal canalVEMP testingEnd organsVestibular myogenic potentialsSound-evoked responsesSprague-Dawley ratsClick-evoked responsesHuman vestibular functionSound sensitivitySternocleidomastoid muscleVestibular functionIrregular afferentsMyogenic potentialsSaccule functionAfferentsRatsCumulative probabilityCVEMPCanalNeural basisBroadband clicks