2022
De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report
Gandhi S, Klein J, Robertson AJ, Peña-Hernández MA, Lin MJ, Roychoudhury P, Lu P, Fournier J, Ferguson D, Mohamed Bakhash SAK, Catherine Muenker M, Srivathsan A, Wunder EA, Kerantzas N, Wang W, Lindenbach B, Pyle A, Wilen CB, Ogbuagu O, Greninger AL, Iwasaki A, Schulz WL, Ko AI. De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report. Nature Communications 2022, 13: 1547. PMID: 35301314, PMCID: PMC8930970, DOI: 10.1038/s41467-022-29104-y.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionVirologic responsePersistent SARS-CoV-2 infectionResistance mutationsPre-treatment specimensB-cell deficiencyRemdesivir resistanceRemdesivir therapyViral sheddingCase reportAntiviral agentsPatientsCombinatorial therapyInfectionTherapyWhole-genome sequencingTreatmentImportance of monitoringDe novo emergenceFold increaseRNA-dependent RNA polymeraseNovo emergencePotential benefitsMutationsIndolent
2020
Impact of intra-tumoral heterogeneity detected by next-generation sequencing on acute myeloid leukemia survival
Schulz WL, Rinder HM, Durant TJS, Tormey CA, Torres R, Smith BR, Hager KM, Howe JG, Siddon AJ. Impact of intra-tumoral heterogeneity detected by next-generation sequencing on acute myeloid leukemia survival. Leukemia & Lymphoma 2020, 61: 3269-3271. PMID: 32715805, DOI: 10.1080/10428194.2020.1797016.Peer-Reviewed Original Research
2010
HOS2 and HDA1 Encode Histone Deacetylases with Opposing Roles in Candida albicans Morphogenesis
Zacchi LF, Schulz WL, Davis DA. HOS2 and HDA1 Encode Histone Deacetylases with Opposing Roles in Candida albicans Morphogenesis. PLOS ONE 2010, 5: e12171. PMID: 20730094, PMCID: PMC2921335, DOI: 10.1371/journal.pone.0012171.Peer-Reviewed Original ResearchMeSH KeywordsCandida albicansHistone DeacetylasesHydrogen-Ion ConcentrationHyphaeMutagenesisMutationConceptsHistone deacetylasesHuman fungal pathogen Candida albicansFungal pathogen Candida albicansHuman pathogen C. albicansVirulence traitsRole of HDACsWhite-opaque switchingC. albicans morphogenesisCandida albicans MorphogenesisPathogen Candida albicansYeast-hyphal transitionCritical virulence attributeDifferent environmental stimuliPathogen C. albicansMorphogenetic transitionEpigenetic mechanismsHyphal formationC. albicansHos2Diverse pathogensMorphogenesisEnvironmental stimuliVirulence attributesHOS1Opposing roles
2007
Interactions between multiple genetic determinants in the 5′ UTR and VP1 capsid control pathogenesis of chronic post-viral myopathy caused by coxsackievirus B1
Sandager MM, Nugent JL, Schulz WL, Messner RP, Tam PE. Interactions between multiple genetic determinants in the 5′ UTR and VP1 capsid control pathogenesis of chronic post-viral myopathy caused by coxsackievirus B1. Virology 2007, 372: 35-47. PMID: 18029287, PMCID: PMC2352162, DOI: 10.1016/j.virol.2007.10.020.Peer-Reviewed Original ResearchConceptsVP1 capsidLimb muscle weaknessGenetic determinantsClinical manifestationsMuscle weaknessAntibody responseViral determinantsCoxsackievirus B1Viral titersMiceUnderlying mechanismPathogenesisMyopathyMultiple genetic determinantsCurrent studyDifferent genetic backgroundsGenetic backgroundSecond strainFull attenuationDeterminantsMyositisTitersEnterovirusesComplex interplay