2023
Development and external validation of machine learning algorithms for postnatal gestational age estimation using clinical data and metabolomic markers
Hawken S, Ducharme R, Murphy M, Olibris B, Bota A, Wilson L, Cheng W, Little J, Potter B, Denize K, Lamoureux M, Henderson M, Rittenhouse K, Price J, Mwape H, Vwalika B, Musonda P, Pervin J, Chowdhury A, Rahman A, Chakraborty P, Stringer J, Wilson K. Development and external validation of machine learning algorithms for postnatal gestational age estimation using clinical data and metabolomic markers. PLOS ONE 2023, 18: e0281074. PMID: 36877673, PMCID: PMC9987787, DOI: 10.1371/journal.pone.0281074.Peer-Reviewed Original ResearchConceptsGestational ageCord blood dataClinical dataBlood dataMetabolomic markersEarly pregnancy ultrasoundHeel-prick blood sampleProspective birth cohortMultivariable linear regressionBlood sample dataExternal validationGestational age estimationRetrospective cohortPregnancy ultrasoundHeel prickExternal cohortIndependent cohortBlood samplesBirth cohortNewbornsPostnatal gestational age estimationCohortUltrasound estimatesInternal model validationLow-income countries
2022
Performance of single serum progesterone in the evaluation of symptomatic first-trimester pregnant patients: a systematic review and meta-analysis
Ghaedi B, Cheng W, Ameri S, Abdulkarim K, Costain N, Zia A, Thiruganasambandamoorthy V. Performance of single serum progesterone in the evaluation of symptomatic first-trimester pregnant patients: a systematic review and meta-analysis. Canadian Journal Of Emergency Medicine 2022, 24: 611-621. PMID: 35921048, DOI: 10.1007/s43678-022-00332-x.Peer-Reviewed Original ResearchConceptsNon-viable pregnancyPregnancy viabilityViable pregnancyDiagnostic odds ratioProgesterone levelsFirst trimester pregnant patientsSingle serum progesterone levelSingle serum progesteroneUseful prognostic informationSerum progesterone levelsValue of progesteroneSensitivity 91.3Pregnant patientsSymptomatic patientsCochrane DatabaseFirst trimesterSerum progesteronePrognostic informationOdds ratioPrevalence ratesPatientsPregnancySummary estimatesSpecificity 75Predictive value