1976
Treatment of Pneumocystis carinii pneumonia: current status of the regimens of pentamidine isethionate and pyrimethamine-sulfadiazine.
Young R, DeVita V. Treatment of Pneumocystis carinii pneumonia: current status of the regimens of pentamidine isethionate and pyrimethamine-sulfadiazine. National Cancer Institute Monograph 1976, 43: 193-200. PMID: 1087955.Peer-Reviewed Original ResearchConceptsPyrimethamine-sulfadiazinePneumocystis pneumoniaPentamidine isethionateClinical trialsPneumocystis carinii pneumoniaManagement of patientsSeverely ill patientsRandomized clinical trialsCarinii pneumoniaLocal toxicityRegimensIll patientsPatientsComplete recoveryPneumoniaPneumocystisIsethionateComparative toxicityTrialsPentamidineToxicityPneumocystis pneumonia in patients with cancer: clinical setting.
DeVita V, Goodell B, Hubbard S, Geelhoed G, Young R. Pneumocystis pneumonia in patients with cancer: clinical setting. National Cancer Institute Monograph 1976, 43: 41-7. PMID: 1087959.Peer-Reviewed Original ResearchConceptsPneumocystis pneumoniaClinical settingTreated with combination chemotherapyDevelopment of Pneumocystis pneumoniaWithdrawal of chemotherapyCombination chemotherapyClinical remissionHematologic malignanciesEmpirical treatmentSolid tumorsInfectious deathCancer patientsPatientsPentamidine isethionatePneumoniaAcute formChemotherapyTumorCancerRemissionUncontrolled growthMalignancyPneumocystis
1970
Pentamidine: Clinical pharmacologic correlations in man and mice
Waalkes T, Denham C, DeVita V. Pentamidine: Clinical pharmacologic correlations in man and mice. Clinical Pharmacology & Therapeutics 1970, 11: 505-512. PMID: 5310706, DOI: 10.1002/cpt1970114505.Peer-Reviewed Original ResearchConceptsDiffuse interstitial pneumoniaInterstitial pneumoniaUrinary excretionPlasma levelsPneumocystis cariniiSingle intraperitoneal injectionTypes of pneumoniaDosage scheduleCancer patientsMalignant diseaseRenal abnormalitiesConcomitant useIntraperitoneal injectionIntramuscular administrationOrgan transplantationExcretion patternsPatientsPneumoniaPentamidineExcretionDrugsMenDiseaseMiceCarinii
1969
Aspergillus Lobar Pneumonia
Young R, Vogel C, DeVita V. Aspergillus Lobar Pneumonia. JAMA 1969, 208: 1156-1162. PMID: 5818713, DOI: 10.1001/jama.1969.03160070034008.Peer-Reviewed Original ResearchConceptsPleuritic chest painConsistent with pathological findingsLobar pneumoniaChest painPulmonary embolismFungal pneumoniaLobar consolidationVascular invasionHematopoietic malignanciesAspergillus fumigatusClinical symptomsPathological findingsPneumoniaBacterial agentsPatientsAspergillosisHemoptysisChemotherapyPneumonitisCorticosteroidsLeukopeniaMalignancyEmbolizationHemorrhagePainPneumocystis carinii Pneumonia — Successful Diagnosis and Treatment of Two Patients with Associated Malignant Processes
DeVita V, Emmer M, Levine A, Jacobs B, Berard C. Pneumocystis carinii Pneumonia — Successful Diagnosis and Treatment of Two Patients with Associated Malignant Processes. New England Journal Of Medicine 1969, 280: 287-291. PMID: 5303991, DOI: 10.1056/nejm196902062800602.Peer-Reviewed Original ResearchConceptsNeedle biopsyMalignant processPentamidine isethionatePneumocystis carinii pneumoniaProper clinical settingPotential renal toxicityRenal functionAdequate therapyCarinii pneumoniaRenal toxicityPneumocystis infectionTubular disordersTherapeutic efficacyClinical settingFurther experiencePatientsBiopsyIsethionateTherapyInfectionDiagnosisValid assessmentPneumoniaPhysiciansDose