1979
Treatment of refractory splenomegaly in myeloproliferative disease by splenic artery infusion.
Canellos G, Sutliffe S, DeVita V, Lister T. Treatment of refractory splenomegaly in myeloproliferative disease by splenic artery infusion. Blood 1979, 53: 1014-7. PMID: 435637, DOI: 10.1182/blood.v53.5.1014.bloodjournal5351014.Peer-Reviewed Original ResearchConceptsSplenic artery infusionArterial infusionBlastic phase of chronic granulocytic leukemiaRefractory to previous therapyPhase of chronic granulocytic leukemiaChronic granulocytic leukemiaResponse to treatmentBlastic phasePrevious therapyMassive splenomegalyMyeloproliferative diseaseSystemic toxicityGranulocytic leukemiaSpleen sizeSymptomatic reliefCytosine arabinosidePatientsSplenomegalyInfusionTreatmentHypersplenismPainLeukemiaTherapyArabinosideTreatment of Refractory Splenomegaly in Myeloproliferative Disease by Splenic Artery Infusion
Canellos G, Sutliffe S, DeVita V, Lister T. Treatment of Refractory Splenomegaly in Myeloproliferative Disease by Splenic Artery Infusion. Blood 1979, 53: 1014-1017. DOI: 10.1182/blood.v53.5.1014.1014.Peer-Reviewed Original ResearchSplenic artery infusionArterial infusionBlastic phase of chronic granulocytic leukemiaRefractory to previous therapyPhase of chronic granulocytic leukemiaChronic granulocytic leukemiaResponse to treatmentBlastic phasePrevious therapyMassive splenomegalyMyeloproliferative diseaseSystemic toxicityGranulocytic leukemiaSpleen sizeSymptomatic reliefCytosine arabinosidePatientsSplenomegalyInfusionTreatmentHypersplenismPainLeukemiaTherapyArabinoside
1977
Characteristics of Blast Crisis in Chronic Granulocytic Leukemia
Rosenthal S, Canellos G, DeVita V, Gralnick H. Characteristics of Blast Crisis in Chronic Granulocytic Leukemia. Blood 1977, 49: 705-714. DOI: 10.1182/blood.v49.5.705.705.Peer-Reviewed Original ResearchCharacteristics of blast crisis in chronic granulocytic leukemia.
Rosenthal S, Canellos G, DeVita V, Gralnick H. Characteristics of blast crisis in chronic granulocytic leukemia. Blood 1977, 49: 705-14. PMID: 265737, DOI: 10.1182/blood.v49.5.705.bloodjournal495705.Peer-Reviewed Original ResearchConceptsChronic granulocytic leukemiaBlast crisisExtramedullary leukemiaGranulocytic leukemiaDiagnosis of blast crisisPh1-positive chronic granulocytic leukemiaLymphoblastic groupAcute leukemiaPeripheral bloodHematological criteriaHematological featuresBone marrowLeukemiaMorphological subgroupsPatientsThrombocytopeniaTerminal phaseMarrow
1976
Chemotherapy of the blastic phase of chronic granulocytic leukemia: hypodiploidy and response to therapy.
Canellos G, DeVita V, Whang-Peng J, Chabner B, Schein P, Young R. Chemotherapy of the blastic phase of chronic granulocytic leukemia: hypodiploidy and response to therapy. Blood 1976, 47: 1003-9. PMID: 1064434, DOI: 10.1182/blood.v47.6.1003.bloodjournal4761003.Peer-Reviewed Original ResearchConceptsChromosome-positive chronic granulocytic leukemiaChronic granulocytic leukemiaBlastic phaseComplete remissionPrior splenectomyComplete remittersGranulocytic leukemiaCytosine arabinosidePhiladelphia chromosome-positive chronic granulocytic leukemiaNonsplenectomized groupPrednisone groupPartial remissionMedian survivalElective splenectomyPartial responseSecondary therapyChronic phaseOpposite regimenRemissionSplenectomyVincristinePrednisoneChemotherapyPatientsCell linesChemotherapy of the Blastic Phase of Chronic Granulocytic Leukemia: Hypodiploidy and Response to Therapy
Canellos G, DeVita V, Whang-Peng J, Chabner B, Schein P, Young R. Chemotherapy of the Blastic Phase of Chronic Granulocytic Leukemia: Hypodiploidy and Response to Therapy. Blood 1976, 47: 1003-1009. DOI: 10.1182/blood.v47.6.1003.1003.Peer-Reviewed Original ResearchChromosome-positive chronic granulocytic leukemiaChronic granulocytic leukemiaBlastic phaseComplete remissionPrior splenectomyComplete remittersGranulocytic leukemiaCytosine arabinosidePhiladelphia chromosome-positive chronic granulocytic leukemiaNonsplenectomized groupPrednisone groupPartial remissionMedian survivalElective splenectomyPartial responseSecondary therapyChronic phaseOpposite regimenRemissionPrednisoneVincristineSplenectomyChemotherapyPatientsCell linesSplenectomy in the chronic phase of chronic granulocytic leukemia. Effects in 32 patients.
Ihde D, Canellos G, Schwartz J, DeVita V. Splenectomy in the chronic phase of chronic granulocytic leukemia. Effects in 32 patients. Annals Of Internal Medicine 1976, 84: 17-21. PMID: 1060395, DOI: 10.7326/0003-4819-84-1-17.Peer-Reviewed Original ResearchConceptsChronic phase of chronic granulocytic leukemiaPhase of chronic granulocytic leukemiaChronic granulocytic leukemiaChronic phaseGranulocytic leukemiaPhiladelphia chromosome-positive patientsSurvival of patientsYear of diagnosisChronic phase of diseasePhase of diseaseMedian survivalProphylactic splenectomySplenectomy patientsPlatelet transfusionsElective splenectomyAdequate therapyMassive splenomegalyBlastic transformationEarly diseaseSplenectomyInfluence survivalPatientsStage of illnessLeukemiaSurvival
1975
Dibromomannitol in the treatment of chronic granulocytic leukemia: a prospective randomized comparison with busulfan.
Canellos G, Young R, Neiman P, DeVita V. Dibromomannitol in the treatment of chronic granulocytic leukemia: a prospective randomized comparison with busulfan. Blood 1975, 45: 197-203. PMID: 1054609, DOI: 10.1182/blood.v45.2.197.bloodjournal452197.Peer-Reviewed Original ResearchConceptsTreatment of chronic granulocytic leukemiaBusulfan-treated patientsChronic granulocytic leukemiaGranulocytic leukemiaMedian duration of disease controlChronic phase of CGLDuration of disease controlContinuous maintenance therapyElevated leukocyte countTreated with busulfanIncreased skin pigmentationMyelosuppressive actionRemission inductionMaintenance therapyMedian survivalMedian durationBlastic transformationPulmonary fibrosisBusulfanRandomized comparisonChronic phaseLeukocyte countDibromomannitolPatientsCytological dysplasiaDibromomannitol in the Treatment of Chronic Granulocytic Leukemia: A Prospective Randomized Comparison With Busulfan
Canellos G, Young R, Nieman P, DeVita V. Dibromomannitol in the Treatment of Chronic Granulocytic Leukemia: A Prospective Randomized Comparison With Busulfan. Blood 1975, 45: 197-203. DOI: 10.1182/blood.v45.2.197.197.Peer-Reviewed Original ResearchTreatment of chronic granulocytic leukemiaBusulfan-treated patientsChronic granulocytic leukemiaGranulocytic leukemiaRandomized comparisonMedian duration of disease controlChronic phase of CGLDuration of disease controlContinuous maintenance therapyElevated leukocyte countTreated with busulfanProspective randomized comparisonIncreased skin pigmentationMyelosuppressive actionRemission inductionMedian survivalMaintenance therapyMedian durationBlastic transformationPulmonary fibrosisBusulfanChronic phaseLeukocyte countDibromomannitolPatients
1974
Thrombocytosis in Chronic Granulocytic Leukemia: Incidence and Clinical Significance
Mason J, DeVita V, Canellos G. Thrombocytosis in Chronic Granulocytic Leukemia: Incidence and Clinical Significance. Blood 1974, 44: 483-487. PMID: 4528824, DOI: 10.1182/blood.v44.4.483.483.Peer-Reviewed Original ResearchConceptsChronic granulocytic leukemiaPlatelet countGranulocytic leukemiaClinical significanceOccurrence of thrombocytosisElevated platelet countThrombohemorrhagic complicationsUntreated patientsMedian durationShorter survivalBlastic crisisNormal countsPatientsSubsequent courseThrombocytosisLeukemiaCountEntire courseGroupCourseComplicationsClinicIncidenceDiagnosis
1971
Hematologic and Cytogenetic Remission of Blastic Transformation in Chronic Granulocytic Leukemia
Canellos G, DeVita V, Whang-Peng J, Carbone P. Hematologic and Cytogenetic Remission of Blastic Transformation in Chronic Granulocytic Leukemia. Blood 1971, 38: 671-679. PMID: 5288508, DOI: 10.1182/blood.v38.6.671.671.Peer-Reviewed Original ResearchConceptsChronic granulocytic leukemiaBlastic phaseChronic phaseGranulocytic leukemiaBlastic transformationGood partial remissionComplete hematologic remissionCombination of vincristineCell linesResistant cell linesComplete remissionHematologic remissionPartial remissionCytogenetic remissionSubsequent relapseRemissionPatientsFavorable responseDiseaseHypercalcemia in chronic granulocytic leukemia
Haskell C, Devita V, Canellos G. Hypercalcemia in chronic granulocytic leukemia. Cancer 1971, 27: 872-880. PMID: 5280374, DOI: 10.1002/1097-0142(197104)27:4<872::aid-cncr2820270417>3.0.co;2-d.Peer-Reviewed Original Research