2023
Cell-free fetal DNA impairs trophoblast migration in a TLR9-dependent manner and can be reversed by hydroxychloroquine
León-Martínez D, Lynn T, Abrahams V. Cell-free fetal DNA impairs trophoblast migration in a TLR9-dependent manner and can be reversed by hydroxychloroquine. Journal Of Reproductive Immunology 2023, 157: 103945. PMID: 37062109, DOI: 10.1016/j.jri.2023.103945.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Aspirin-triggered lipoxinsODN 2216Pathogenesis of preeclampsiaTLR9-dependent mannerNovel therapeutic approachesTrophoblast cell modelReceptor 9CpG oligodeoxynucleotideTLR9 inhibitorPlacental functionTherapeutic approachesCell-free fetal DNACpG motifsTherapeutic agentsHCQPreeclampsiaHydroxychloroquineFetal DNACell viabilityCffDNAMolecular underpinningsCell modelInhibitionASA
2018
Role of NOD2 in antiphospholipid antibody-induced and bacterial MDP amplification of trophoblast inflammation
Mulla MJ, Pasternak MC, Salmon JE, Chamley LW, Abrahams VM. Role of NOD2 in antiphospholipid antibody-induced and bacterial MDP amplification of trophoblast inflammation. Journal Of Autoimmunity 2018, 98: 103-112. PMID: 30594350, DOI: 10.1016/j.jaut.2018.12.003.Peer-Reviewed Original ResearchConceptsMuramyl dipeptideAbsence of aPLAnti-angiogenic profileNovel danger signalPresence of aPLRole of NOD2IL-1β expressionMaternal-fetal interfaceActivation of NOD2IL-1β productionBacterial muramyl dipeptideAntiphospholipid antibodiesCommon bacterial componentsPregnancy complicationsPregnancy outcomesAdverse outcomesIL-1βTrophoblast responsesExtravillous trophoblastsHigh riskPreeclampsiaDanger signalsBacterial infectionsVEGF secretionInflammation
2008
Pre‐eclampsia is associated with dendritic cell recruitment into the uterine decidua
Huang S, Chen C, Schatz F, Rahman M, Abrahams V, Lockwood C. Pre‐eclampsia is associated with dendritic cell recruitment into the uterine decidua. The Journal Of Pathology 2008, 214: 328-336. PMID: 18069648, DOI: 10.1002/path.2257.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesCell MovementCells, CulturedChemokinesCulture Media, ConditionedDeciduaDendritic CellsEnzyme-Linked Immunosorbent AssayFemaleGene Expression ProfilingHumansImmunohistochemistryInterleukin-1betaOligonucleotide Array Sequence AnalysisPre-EclampsiaPregnancyPregnancy Trimester, FirstPregnancy Trimester, ThirdReverse Transcriptase Polymerase Chain ReactionUp-RegulationConceptsFirst trimester decidual cellsDendritic cell infiltrationDendritic cellsDecidual cellsIL-1betaPre-eclampsiaCell infiltrationLeukocyte-free first trimester decidual cellsSpecialized antigen-presenting cellsDecidual dendritic cellsDendritic cell recruitmentPlacental bed biopsiesMature dendritic cellsPro-inflammatory cytokinesAntigen-presenting cellsMarked infiltratesMaternal morbidityPrimiparous patientsSystemic inflammationImmune toleranceSubsequent pregnancyBed biopsiesInflammatory milieuMacrophage infiltrationLeading cause