2016
Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea
Jafari B, Mohsenin V. Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea. Sleep Medicine 2016, 25: 87-92. PMID: 27823723, DOI: 10.1016/j.sleep.2016.08.001.Peer-Reviewed Original ResearchConceptsHypertensive OSAObstructive sleep apneaFlow-mediated vasodilationEndothelial dysfunctionYKL-40Sleep apneaEndothelial-dependent vasodilatory capacityNormotensive OSAChitinase-3-like protein 1Sleep-disordered breathingCharacteristic curve analysisChitinase-3-like proteinHypertension independentVasodilatory capacityCardiovascular morbidityEndothelial functionHypertension statusRisk factorsPrevalent disorderHypertensionNegative correlationDysfunctionPotential biomarkersSignificant negative correlationCurve analysisModafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence
Morgan PT, Angarita GA, Canavan S, Pittman B, Oberleitner L, Malison RT, Mohsenin V, Hodges S, Easton C, McKee S, Bessette A, Forselius E. Modafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence. Drug And Alcohol Dependence 2016, 160: 49-56. PMID: 26777774, PMCID: PMC4767553, DOI: 10.1016/j.drugalcdep.2015.12.004.Peer-Reviewed Original ResearchConceptsUrine toxicology screenModafinil treatmentSlow-wave sleepClinical outcomesOutpatient treatmentToxicology screenUrine screensInpatient settingInpatient treatmentSleep timeCocaine dependencePrimary clinical outcomeWeekly cognitive behavioral therapyCocaine usersImproved clinical outcomesPolysomnographic sleep recordingsChronic cocaine useChronic cocaine usersHigh rateCognitive behavioral therapyCocaine-dependent participantsSleep architectureOutpatient phaseEffective treatmentDays abstinent
1999
Nitric oxide production and absorption in trachea, bronchi, bronchioles, and respiratory bronchioles of humans
DuBois A, Kelley P, Douglas J, Mohsenin V. Nitric oxide production and absorption in trachea, bronchi, bronchioles, and respiratory bronchioles of humans. Journal Of Applied Physiology 1999, 86: 159-167. PMID: 9887126, DOI: 10.1152/jappl.1999.86.1.159.Peer-Reviewed Original ResearchQuality of Life in Patients with Obstructive Sleep Apnea Effect of Nasal Continuous Positive Airway Pressure—A Prospective Study
D’Ambrosio C, Bowman T, Mohsenin V. Quality of Life in Patients with Obstructive Sleep Apnea Effect of Nasal Continuous Positive Airway Pressure—A Prospective Study. CHEST Journal 1999, 115: 123-129. PMID: 9925072, DOI: 10.1378/chest.115.1.123.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaQuality of lifeMental healthMedical Outcomes Study Short Form-36 questionnaireNasal continuous positive airway pressure treatmentEffect of OSAContinuous positive airway pressure (CPAP) treatmentNasal continuous positive airway pressureDiagnosis of OSASocial functioningPositive airway pressure treatmentContinuous positive airway pressureShort Form-36 questionnaireEffect of nCPAPPositive airway pressureRespiratory disturbance indexSleep-disordered breathingBody mass indexEvents/hGender-matched populationCase series analysisSeverity of diseaseMagnitude of improvementNCPAP levelNCPAP therapy
1998
Production and absorption of nitric oxide gas in the nose
Dubois A, Douglas J, Stitt J, Mohsenin V. Production and absorption of nitric oxide gas in the nose. Journal Of Applied Physiology 1998, 84: 1217-1224. PMID: 9516187, DOI: 10.1152/jappl.1998.84.4.1217.Peer-Reviewed Original ResearchSLEEP IN ASTHMA
D'Ambrosio C, Mohsenin V. SLEEP IN ASTHMA. Clinics In Chest Medicine 1998, 19: 127-137. PMID: 9554223, DOI: 10.1016/s0272-5231(05)70437-8.Peer-Reviewed Original Research
1996
Adaptation of Lung Antioxidants to Cigarette Smoking in Humans
Hilbert J, Mohsenin V. Adaptation of Lung Antioxidants to Cigarette Smoking in Humans. CHEST Journal 1996, 110: 916-920. PMID: 8874245, DOI: 10.1378/chest.110.4.916.Peer-Reviewed Original ResearchConceptsLung lavage cellsBeta-carotene levelsVitamin EBAL cellsLavage cellsMicronutrient antioxidantsSuperoxide dismutaseGPx activityAntioxidant enzyme activitiesWeeks of supplementationBeta-carotene concentrationsGlutathione peroxidase activityIntracellular superoxide dismutaseFree radical scavengerSerum levelsCigarette smokersCigarette smokingControl subjectsBronchoalveolar cellsLung antioxidantsSmokersNonsmokersConcentration of vitaminSOD activityEnzyme activityInhibition of phospholipase D and superoxide generation by glucose in diabetic neutrophils
Ortmeyer J, Mohsenin V. Inhibition of phospholipase D and superoxide generation by glucose in diabetic neutrophils. Life Sciences 1996, 59: 255-262. PMID: 8699936, DOI: 10.1016/0024-3205(96)00284-6.Peer-Reviewed Original ResearchConceptsDiabetic neutrophilsSuperoxide generationInsulin-dependent diabeticsGlucose concentrationNormal glucose concentrationN-formyl-MetNeutrophil dysfunctionPhospholipase DHigh glucose concentrationsImpaired activationDiabeticsNeutrophilsLeu-PheMembrane phosphatidylcholineActivationDiabetesDysfunctionInfectionFMLPPhosphatidic acidResponse
1995
Effect of nitrous acid on lung function in asthmatics: a chamber study.
Beckett W, Russi M, Haber A, Rivkin R, Sullivan J, Tameroglu Z, Mohsenin V, Leaderer B. Effect of nitrous acid on lung function in asthmatics: a chamber study. Environmental Health Perspectives 1995, 103: 372-375. PMID: 7607138, PMCID: PMC1519093, DOI: 10.1289/ehp.95103372.Peer-Reviewed Original ResearchConceptsSignificant airflow obstructionChamber exposure studiesFiltered room airModerate cycle exerciseNitrous acid exposureIndoor nitrogen dioxideMucous membrane symptomsDuration of exposureAirflow obstructionLung functionIrritant symptomsVital capacityCycle exerciseLung mechanicsRespiratory effectsAcid exposureRespiratory parametersAdult subjectsRoom airHealth effectsSymptomsSignificant decreaseAsthmaticsExposure studiesCommon indoor air pollutantsSleep apnea in patients with hemispheric stroke
Mohsenin V, Valor R. Sleep apnea in patients with hemispheric stroke. Archives Of Physical Medicine And Rehabilitation 1995, 76: 71-76. PMID: 7811179, DOI: 10.1016/s0003-9993(95)80046-8.Peer-Reviewed Original ResearchConceptsSleep-disordered breathingHemispheric strokeCerebral symptomsSleep apneaStroke patientsRapid eye movement (REM) sleepArterial oxygen desaturationComplications of strokePresence of hypertensionRespiratory disturbance indexBody mass indexAbnormal sleep architectureEye movement sleepSlow-wave sleepOxygen desaturationGroups of subjectsBrainstem lesionsCerebrovascular accidentCerebral strokeMass indexRespiratory disturbancesRespiratory eventsMovement sleepSleep architecturePrior history
1991
Lipid peroxidation and antielastase activity in the lung under oxidant stress: role of antioxidant defenses
Mohsenin V. Lipid peroxidation and antielastase activity in the lung under oxidant stress: role of antioxidant defenses. Journal Of Applied Physiology 1991, 70: 1456-1462. PMID: 2055821, DOI: 10.1152/jappl.1991.70.4.1456.Peer-Reviewed Original ResearchConceptsElastase inhibitory capacityAlveolar lining fluidLipid peroxidation productsLining fluidLavage fluidVitamin-supplemented groupOxidant stressLipid peroxidationPeroxidation productsControl groupLower respiratory tract fluidFour-week supplementationVitamin CRespiratory tract fluidNO2 exposureInactivation of alphaConjugated dienesVitamin supplementationNormal subjectsAntielastase activityInhibitory capacityOxidant exposureSignificant decreaseAntioxidant defensePeroxidation
1988
Airway Responses to 2.0 ppm Nitrogen Dioxide in Normal Subjects
Mohsenin V. Airway Responses to 2.0 ppm Nitrogen Dioxide in Normal Subjects. Archives Of Environmental & Occupational Health 1988, 43: 242-246. PMID: 3289507, DOI: 10.1080/00039896.1988.9934941.Peer-Reviewed Original ResearchConceptsSpecific airway conductanceLung function testsAirway reactivityMethacholine aerosolAirway conductanceFunction testsVital capacityNormal subjectsDouble-blind randomized fashionPartial expiratory flowDose of methacholineConcentration of methacholineAcute respiratory responsesFunctional residual capacityPpm nitrogen dioxideAirway responsesMethacholine inhalationExpiratory volumeRespiratory symptomsNormal nonsmokersExpiratory flowLung volumeRandomized fashionRespiratory responsesResidual capacity
1987
Airway responses to nitrogen dioxide in asthmatic subjects
Mohsenin V. Airway responses to nitrogen dioxide in asthmatic subjects. Journal Of Toxicology And Environmental Health 1987, 22: 371-380. PMID: 3320381, DOI: 10.1080/15287398709531080.Peer-Reviewed Original ResearchConceptsAirway reactivityVital capacityAsthmatic subjectsDouble-blind randomized fashionPartial expiratory flowSpecific airway conductanceDose of methacholineNO2 exposureFunctional residual capacityAirway conductanceAirway responsesMethacholine inhalationExpiratory volumeLung functionExpiratory flowSignificant potentiationSignificant symptomsRandomized fashionRespiratory responsesResidual capacityAsthmaticsCommon indoor air pollutantsExposureSignificant changesDifferent daysEffect of Vitamin C on NO2-induced Airway Hyperresponsiveness in Normal Subjects: A Randomized Double-Blind Experiment
Mohsenin V. Effect of Vitamin C on NO2-induced Airway Hyperresponsiveness in Normal Subjects: A Randomized Double-Blind Experiment. American Journal Of Respiratory And Critical Care Medicine 1987, 136: 1408-1411. PMID: 3318598, DOI: 10.1164/ajrccm/136.6.1408.Peer-Reviewed Original ResearchAcute Effect of Nitrogen Dioxide Exposure on the Functional Activity of Alpha-1-Protease Inhibitor in Bronchoalveolar Lavage Fluid of Normal Subjects
Mohsenin V, Gee J. Acute Effect of Nitrogen Dioxide Exposure on the Functional Activity of Alpha-1-Protease Inhibitor in Bronchoalveolar Lavage Fluid of Normal Subjects. American Journal Of Respiratory And Critical Care Medicine 1987, 136: 646-650. PMID: 3498415, DOI: 10.1164/ajrccm/136.3.646.Peer-Reviewed Original ResearchConceptsBronchoalveolar lavage fluidAlpha-1-protease inhibitorAlpha 1PILavage fluidControl subjectsFunctional activityLower respiratory tract fluidRespiratory tract fluidHuman leukocyte elastaseNitrogen dioxide exposureSignificant differencesEnd of exposureImmunoreactive alpha 1PIBronchoalveolar lavageNeutrophil migrationAcute effectsIntermittent exerciseNormal subjectsCigarette smokeControl groupHLE activityBALNO2 exposureNonsmokersLeukocyte elastase
1983
Effect of Ascorbic Acid on Response to Methacholine Challenge in Asthmatic Subjects1–3
Mohsenin V, Dubois A, Douglas J. Effect of Ascorbic Acid on Response to Methacholine Challenge in Asthmatic Subjects1–3. American Journal Of Respiratory And Critical Care Medicine 1983, 127: 143-7. PMID: 6830027, DOI: 10.1164/arrd.1983.127.2.143.Peer-Reviewed Original Research