2015
Obstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the Block
Mohsenin V. Obstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the Block. The American Journal Of Medicine 2015, 128: 811-816. PMID: 25731137, DOI: 10.1016/j.amjmed.2015.01.037.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaRisk factorsPersistent neurologic impairmentStroke-related outcomesGood neurologic outcomePresence of hypertensionMajority of patientsRisk of strokeTraditional risk factorsCommon comorbid conditionsCause of deathNeurologic outcomeNeurologic recoverySecondary preventionComorbid conditionsNeurologic impairmentAtrial fibrillationDiagnostic workupEarly recognitionStroke rateApneaTherapeutic targetHealthcare providersStroke
2004
Is sleep apnea a risk factor for stroke? A critical analysis.
Mohsenin V. Is sleep apnea a risk factor for stroke? A critical analysis. Minerva Medica 2004, 95: 291-305. PMID: 15334043.Peer-Reviewed Original ResearchConceptsModifiable risk factorsSleep apneaRisk factorsSleep-related breathing disordersSerious long-term disabilityDevelopment of strokeObstructive sleep apneaCoronary artery diseaseLong-term disabilityManagement of strokePathogenesis of strokeRecent large epidemiological studiesCause of deathLarge epidemiological studiesArterial hypertensionNeurologic recoveryAcute strokeArtery diseaseHemodynamic changesSignificant morbidityBreathing disordersProspective studyCardiac diseaseTherapeutic approachesApnea
2001
Sleep-Related Breathing Disorders and Risk of Stroke
Mohsenin V. Sleep-Related Breathing Disorders and Risk of Stroke. Stroke 2001, 32: 1271-1278. PMID: 11387486, DOI: 10.1161/01.str.32.6.1271.Peer-Reviewed Original ResearchConceptsSleep-related breathing disordersTransient ischemic attackRisk of strokeBreathing disordersRisk factorsSleep apnea disorderIschemic attackApnea disorderHematologic changesHigh prevalenceNormal sleep stateModifiable risk factorsPresence of hypertensionRecent large epidemiological studiesPossible pathogenetic mechanismsLarge epidemiological studiesDiurnal hypertensionCerebral perfusionSignificant morbidityCerebral hemodynamicsPathogenetic mechanismsEpidemiological studiesStrokeHypertensionPatients
2000
Sleep-related breathing disorders and cardiovascular disease
Roux F, D’Ambrosio C, Mohsenin V. Sleep-related breathing disorders and cardiovascular disease. The American Journal Of Medicine 2000, 108: 396-402. PMID: 10759096, DOI: 10.1016/s0002-9343(00)00302-8.Peer-Reviewed Original ResearchConceptsSleep-related breathing disordersBreathing disordersRisk factorsUpper airway resistance syndromeIndependent risk factorMajority of patientsMajor health problemPulmonary hypertensionSympathetic toneBaroreflex controlIntermittent hypoxiaExcessive daytimeSleep apneaCerebrovascular diseaseResistance syndromeEarly recognitionCardiovascular functionCardiovascular diseaseEpidemiologic studiesNeuropsychological dysfunctionHealth problemsMemory impairmentPoor work performanceDisordersHypertension