1996
Inhibition of phospholipase D and superoxide generation by glucose in diabetic neutrophils
Ortmeyer J, Mohsenin V. Inhibition of phospholipase D and superoxide generation by glucose in diabetic neutrophils. Life Sciences 1996, 59: 255-262. PMID: 8699936, DOI: 10.1016/0024-3205(96)00284-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultDiabetes MellitusDose-Response Relationship, DrugGlucoseHumansNeutrophilsPhospholipase DSuperoxidesConceptsDiabetic neutrophilsSuperoxide generationInsulin-dependent diabeticsGlucose concentrationNormal glucose concentrationN-formyl-MetNeutrophil dysfunctionPhospholipase DHigh glucose concentrationsImpaired activationDiabeticsNeutrophilsLeu-PheMembrane phosphatidylcholineActivationDiabetesDysfunctionInfectionFMLPPhosphatidic acidResponse
1993
Glucose suppresses superoxide generation in normal neutrophils: interference in phospholipase D activation
Ortmeyer J, Mohsenin V. Glucose suppresses superoxide generation in normal neutrophils: interference in phospholipase D activation. American Journal Of Physiology 1993, 264: c402-c410. PMID: 8383432, DOI: 10.1152/ajpcell.1993.264.2.c402.Peer-Reviewed Original ResearchConceptsNormal neutrophilsActivation of PLDNADPH oxidaseTreatment of neutrophilsReceptor-mediated stimulationN-formyl-MetPLD activationDiabetic subjectsFormation of inositolReceptor stimulationPhosphoinositide hydrolysisGlucose suppressesIntracellular Ca2NeutrophilsPhospholipase D activationMarked inhibitionLeu-PhePhospholipase D activityGeneration of O2D activationNonmetabolizable sugarPhosphatidic acidSuperoxide anionActivationGlucose
1991
Unsaturated phosphatidylcholines inhibit superoxide production in human neutrophils
Yoshida K, Mohsenin V. Unsaturated phosphatidylcholines inhibit superoxide production in human neutrophils. Life Sciences 1991, 49: 1359-1365. PMID: 1656156, DOI: 10.1016/0024-3205(91)90200-u.Peer-Reviewed Original Research
1990
Respiratory burst in alveolar macrophages of diabetic rats
Mohsenin V, Latifpour J. Respiratory burst in alveolar macrophages of diabetic rats. Journal Of Applied Physiology 1990, 68: 2384-2390. PMID: 2166735, DOI: 10.1152/jappl.1990.68.6.2384.Peer-Reviewed Original ResearchConceptsPeripheral blood monocytesPhorbol myristate acetateAlveolar macrophagesBlood monocytesInduction of diabetesPMA stimulationEnzyme cycling methodDismutase-inhibitable cytochrome c reductionSuperoxide dismutase-inhibitable cytochrome c reductionNeutrophil O2Diabetes mellitusDiabetic ratsRats 8Basal conditionsDiabeticsAnion generationMacrophagesMyristate acetateMonocytesSignificant differencesDiabetesStimulationCytochrome c reductionRatsRespiratory