2015
Pulmonary Hypertension in Obstructive Sleep Apnea: Is it Clinically Significant? a Critical Analysis of the Association and Pathophysiology
Kholdani C, Fares WH, Mohsenin V. Pulmonary Hypertension in Obstructive Sleep Apnea: Is it Clinically Significant? a Critical Analysis of the Association and Pathophysiology. Pulmonary Circulation 2015, 5: 220-227. PMID: 26064448, PMCID: PMC4449234, DOI: 10.1086/679995.Peer-Reviewed Original ResearchObstructive sleep apneaPulmonary hypertensionPulmonary venous hypertensionVenous hypertensionSleep apneaSetting of OSAPulmonary artery pressurePoor prognostic signHypoxic pulmonary vasoconstrictionMajority of patientsLeft heart dysfunctionAberrant vascular remodelingQuality of lifeResult of apneaVascular cell proliferationArtery pressurePulmonary vasoconstrictionEjection fractionIntermittent hypoxiaPrognostic signHeart dysfunctionLeft heartHigh prevalenceHypertensionVascular remodeling
2013
Hypertension and endothelial dysfunction in obstructive sleep apnea (OSA) – Is it related to hypoxia?
Mohsenin V, Jafari B. Hypertension and endothelial dysfunction in obstructive sleep apnea (OSA) – Is it related to hypoxia? Sleep Medicine 2013, 14: e210. DOI: 10.1016/j.sleep.2013.11.503.Peer-Reviewed Original ResearchObstructive sleep apneaEndothelial dysfunctionSFlt-1Fms-like tyrosine kinase-1Endothelial-dependent vasodilatory capacitySevere obstructive sleep apneaAngiogenic inhibitorsN-OSACardiovascular adverse outcomesNon-OSA patientsNormotensive OSAS patientsTarget organ damageApnea-hypopnea indexDevelopment of hypertensionArterial oxygen saturationTyrosine kinase-1Significant inverse correlationImpaired FMDIntermittent hypoxemiaSEng concentrationsVasodilatory capacityOSA patientsSympathetic toneIntermittent hypoxiaOrgan damage
2000
Sleep-related breathing disorders and cardiovascular disease
Roux F, D’Ambrosio C, Mohsenin V. Sleep-related breathing disorders and cardiovascular disease. The American Journal Of Medicine 2000, 108: 396-402. PMID: 10759096, DOI: 10.1016/s0002-9343(00)00302-8.Peer-Reviewed Original ResearchConceptsSleep-related breathing disordersBreathing disordersRisk factorsUpper airway resistance syndromeIndependent risk factorMajority of patientsMajor health problemPulmonary hypertensionSympathetic toneBaroreflex controlIntermittent hypoxiaExcessive daytimeSleep apneaCerebrovascular diseaseResistance syndromeEarly recognitionCardiovascular functionCardiovascular diseaseEpidemiologic studiesNeuropsychological dysfunctionHealth problemsMemory impairmentPoor work performanceDisordersHypertension