2015
Pulmonary Hypertension in Obstructive Sleep Apnea: Is it Clinically Significant? a Critical Analysis of the Association and Pathophysiology
Kholdani C, Fares WH, Mohsenin V. Pulmonary Hypertension in Obstructive Sleep Apnea: Is it Clinically Significant? a Critical Analysis of the Association and Pathophysiology. Pulmonary Circulation 2015, 5: 220-227. PMID: 26064448, PMCID: PMC4449234, DOI: 10.1086/679995.Peer-Reviewed Original ResearchObstructive sleep apneaPulmonary hypertensionPulmonary venous hypertensionVenous hypertensionSleep apneaSetting of OSAPulmonary artery pressurePoor prognostic signHypoxic pulmonary vasoconstrictionMajority of patientsLeft heart dysfunctionAberrant vascular remodelingQuality of lifeResult of apneaVascular cell proliferationArtery pressurePulmonary vasoconstrictionEjection fractionIntermittent hypoxiaPrognostic signHeart dysfunctionLeft heartHigh prevalenceHypertensionVascular remodeling
2001
Sleep-Related Breathing Disorders and Risk of Stroke
Mohsenin V. Sleep-Related Breathing Disorders and Risk of Stroke. Stroke 2001, 32: 1271-1278. PMID: 11387486, DOI: 10.1161/01.str.32.6.1271.Peer-Reviewed Original ResearchConceptsSleep-related breathing disordersTransient ischemic attackRisk of strokeBreathing disordersRisk factorsSleep apnea disorderIschemic attackApnea disorderHematologic changesHigh prevalenceNormal sleep stateModifiable risk factorsPresence of hypertensionRecent large epidemiological studiesPossible pathogenetic mechanismsLarge epidemiological studiesDiurnal hypertensionCerebral perfusionSignificant morbidityCerebral hemodynamicsPathogenetic mechanismsEpidemiological studiesStrokeHypertensionPatients