Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi E, Hollander B, Farooq U, Vashchinkina E, Rajkumar R, Nutt D, Hyytiä P, Dawe G. Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse. Pharmacological Reviews 2015, 67: 872-1004. PMID: 26403687, DOI: 10.1124/pr.115.010967.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAmphetaminesAnimalsBehavior, AddictiveBenzodiazepinesBrainCannabinoidsCocaineDepressionDose-Response Relationship, DrugGene ExpressionHallucinogensHumansIllicit DrugsNarcoticsNerve Growth FactorsNeuroimagingNeuronal PlasticityNicotineReceptors, NicotinicReceptors, N-Methyl-D-AspartateSubstance-Related DisordersSynaptic TransmissionConceptsDrugs of abuseAdolescent drug exposureStress-induced reinstatementBehavioral changesBrain processesDrug seekingCognitive alterationsRecreational drug usersAbuseNeuroplasticityNeuropsychiatric illnessAddictionVentral tegmental areaAppropriate responseAdministration of drugsRegion-specific changesBrain cell populationsMechanism of actionDrug intakeDopamine neuronsDrug exposureTegmental areaRelevant doseDrug effectsCues