2021
Privacy-protecting, reliable response data discovery using COVID-19 patient observations
Kim J, Neumann L, Paul P, Day M, Aratow M, Bell D, Doctor J, Hinske L, Jiang X, Kim K, Matheny M, Meeker D, Pletcher M, Schilling L, SooHoo S, Xu H, Zheng K, Ohno-Machado L, Anderson D, Anderson N, Balacha C, Bath T, Baxter S, Becker-Pennrich A, Bernstam E, Carter W, Chau N, Choi Y, Covington S, DuVall S, El-Kareh R, Florian R, Follett R, Geisler B, Ghigi A, Gottlieb A, Hu Z, Ir D, Knight T, Koola J, Kuo T, Lee N, Mansmann U, Mou Z, Murphy R, Neumann L, Nguyen N, Niedermayer S, Park E, Perkins A, Post K, Rieder C, Scherer C, Soares A, Soysal E, Tep B, Toy B, Wang B, Wu Z, Zhou Y, Zucker R. Privacy-protecting, reliable response data discovery using COVID-19 patient observations. Journal Of The American Medical Informatics Association 2021, 28: 1765-1776. PMID: 34051088, PMCID: PMC8194878, DOI: 10.1093/jamia/ocab054.Peer-Reviewed Original Research
2020
EXpectation Propagation LOgistic REgRession on permissioned blockCHAIN (ExplorerChain): decentralized online healthcare/genomics predictive model learning
Kuo T, Gabriel R, Cidambi K, Ohno-Machado L. EXpectation Propagation LOgistic REgRession on permissioned blockCHAIN (ExplorerChain): decentralized online healthcare/genomics predictive model learning. Journal Of The American Medical Informatics Association 2020, 27: 747-756. PMID: 32364235, PMCID: PMC7309256, DOI: 10.1093/jamia/ocaa023.Peer-Reviewed Original ResearchConceptsBlockchain technologyCentral serverServer-based methodBenefits of blockchainData protection policiesCentralized serverArtificial intelligenceModel learningDecentralized approachSmall datasetsBlockchainServerComputation strategySingle pointGeneralizable modelCost of efficiencyGenomic datasetsDatasetDistributed modelTechnologyGenomic dataMultiple institutionsDiscrimination powerIntelligencePotential advantages/disadvantagesPrivacy-preserving model learning on a blockchain network-of-networks
Kuo T, Kim J, Gabriel R. Privacy-preserving model learning on a blockchain network-of-networks. Journal Of The American Medical Informatics Association 2020, 27: 343-354. PMID: 31943009, PMCID: PMC7025358, DOI: 10.1093/jamia/ocz214.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBiomedical ResearchBlockchainComputer Communication NetworksComputer SecurityConfidentialityDatasets as TopicGenomicsInformation SystemsModels, TheoreticalPrivacyConceptsNetwork topologyExecution timeArt methodsPredictive correctnessPrivacy-preserving learningPrivacy-preserving methodsPrivacy-preserving modelSmall training datasetBlockchain networkBlockchain platformBlockchain technologyPrivacy concernsModel learningComplex dataLearning iterationsLearning methodsTraining datasetConsensus algorithmGeneralizable predictive modelsCorrectness resultsModel disseminationHierarchical networkSmall dataHierarchical approachRecord model
2019
‘Fit-for-purpose?’ – challenges and opportunities for applications of blockchain technology in the future of healthcare
Mackey T, Kuo T, Gummadi B, Clauson K, Church G, Grishin D, Obbad K, Barkovich R, Palombini M. ‘Fit-for-purpose?’ – challenges and opportunities for applications of blockchain technology in the future of healthcare. BMC Medicine 2019, 17: 68. PMID: 30914045, PMCID: PMC6436239, DOI: 10.1186/s12916-019-1296-7.Peer-Reviewed Original ResearchConceptsApplication of blockchain technologyHealthcare-related dataBlockchain approachBusiness processesHealth blockchainBlockchain technologyData architectureBlockchainData managementTransform healthcareMultidisciplinary groups of practitionersImprove patient outcomesHealthcare stakeholdersHealthcare needsGroup of practitionersHealth sectorMultidisciplinary groupDesign elementsDataHealthcarePatient outcomesPerspective of consumersTechnologyEnhance complianceLow costFair compute loads enabled by blockchain: sharing models by alternating client and server roles
Kuo T, Gabriel R, Ohno-Machado L. Fair compute loads enabled by blockchain: sharing models by alternating client and server roles. Journal Of The American Medical Informatics Association 2019, 26: 392-403. PMID: 30892656, PMCID: PMC7787356, DOI: 10.1093/jamia/ocy180.Peer-Reviewed Original Research