Viral N protein hijacks deaminase-containing RNA granules to enhance SARS-CoV-2 mutagenesis
Li Z, Luo L, Ju X, Huang S, Lei L, Yu Y, Liu J, Zhang P, Chi T, Ma P, Huang C, Huang X, Ding Q, Zhang Y. Viral N protein hijacks deaminase-containing RNA granules to enhance SARS-CoV-2 mutagenesis. The EMBO Journal 2024, 1-25. PMID: 39567830, DOI: 10.1038/s44318-024-00314-y.Peer-Reviewed Original ResearchRNA granulesHost deaminasesN proteinMutant N proteinPackage viral genomic RNASARS-CoV-2 nucleocapsid (N) proteinSARS-CoV-2 evolutionNucleocapsid (N) proteinViral genomic RNAVirus-host cell interactionsSARS-CoV-2 mutationsADAR deaminasesAntiviral restriction factorsRNA editingGenomic RNAImpaired viral replicationStress granulesRNA mutagenesisSARS-CoV-2Viral genomeMutagenesisBlock viral infectionViral RNARNACo-localizationExpanding RNA editing toolkit using an IDR-based strategy
Di M, Lv J, Jing Z, Yang Y, Yan K, Wu J, Ge J, Rauch S, Dickinson B, Chi T. Expanding RNA editing toolkit using an IDR-based strategy. Molecular Therapy - Nucleic Acids 2024, 35: 102190. PMID: 38721279, PMCID: PMC11077028, DOI: 10.1016/j.omtn.2024.102190.Peer-Reviewed Original Research