Thrombospondin 1 is expressed by proliferating mesangial cells and is up-regulated by PDGF and bFGF in vivo
Hugo C, Pichler R, Meek R, Gordon K, Kyriakides T, Floege J, Bornstein P, Couser W, Johnson R. Thrombospondin 1 is expressed by proliferating mesangial cells and is up-regulated by PDGF and bFGF in vivo. Kidney International 1995, 48: 1846-1856. PMID: 8587244, DOI: 10.1038/ki.1995.483.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionCells, CulturedFibroblast Growth Factor 2Glomerular MesangiumMembrane GlycoproteinsNephritisPlatelet-Derived Growth FactorRatsRNA, MessengerThrombospondinsUp-RegulationConceptsAnti-Thy1 antibodyMesangial cell proliferationThrombospondin-1 expressionMesangial cellsThrombospondin-1Anti-Thy1 nephritisCell proliferationAnti-bFGF antibodyExperimental mesangial proliferative nephritisDe novo expressionMesangial proliferative nephritisGlomerular diseaseNormal ratsProliferative nephritisThrombospondin-1 mRNANovo expressionDouble labelingRatsPDGFAntibodiesNephritisBFGFInfusionDiseaseVivo