2002
Design of “Smart” polymers that can direct intracellular drug delivery
Hoffman A, Stayton P, Press O, Murthy N, Lackey C, Cheung C, Black F, Campbell J, Fausto N, Kyriakides T, Bornstein P. Design of “Smart” polymers that can direct intracellular drug delivery. Polymers For Advanced Technologies 2002, 13: 992-999. DOI: 10.1002/pat.232.Peer-Reviewed Original ResearchPH-sensitive polymerTypes of polymersEndosomal escapeBiomolecular drugsSynthetic polymersPolymeric biomaterialsBiological moleculesPeptide unitsPolymersBiomimetic propertiesEnvironmental signalsEndosomal membranesIntracellular traffickingMolecular mechanismsProtein coatGenetic materialBiological systemsEndosomesViral coatBondsAcidic pHSpecific peptidesInteresting modelLysosomal enzymesTrafficking
2001
Bioinspired polymers that control intracellular drug delivery
Hoffman A, Stayton P, Press O, Murthy N, Lackey C, Cheung C, Black F, Campbell J, Fausto N, Kyriakides T, Bornstein P. Bioinspired polymers that control intracellular drug delivery. Biotechnology And Bioprocess Engineering 2001, 6: 205-212. DOI: 10.1007/bf02931981.Peer-Reviewed Original ResearchPH-sensitive polymerIntracellular drug deliveryBioinspired polymersBiomimetic polymersBiomolecular drugsSynthetic polymersPolymeric biomaterialsBiological moleculesEnvironmental signalsPeptide unitsDrug deliveryPolymersEndosomal membranesBiomimetic propertiesMolecular mechanismsProtein coatViral coatEndosomal escapeBiological systemsInteresting modelSpecific peptidesEndosomesLysosomal enzymesCytoplasmPeptides
2000
Matricellular Proteins as Modulators of Cell–Matrix Interactions: Adhesive Defect in Thrombospondin 2-null Fibroblasts is a Consequence of Increased Levels of Matrix Metalloproteinase-2
Yang Z, Kyriakides T, Bornstein P. Matricellular Proteins as Modulators of Cell–Matrix Interactions: Adhesive Defect in Thrombospondin 2-null Fibroblasts is a Consequence of Increased Levels of Matrix Metalloproteinase-2. Molecular Biology Of The Cell 2000, 11: 3353-3364. PMID: 11029041, PMCID: PMC14997, DOI: 10.1091/mbc.11.10.3353.Peer-Reviewed Original ResearchConceptsCell-matrix interactionsAbnormal cell-matrix interactionsWild-type cellsTSP2-null miceAdhesive defectsComplex phenotypesCell spreadingMolecular mechanismsMutant fibroblastsProtein resultsMatrix proteinsStable transfectionMatrix metalloproteinasesMetalloproteinase-2Matricellular proteinAltered expressionTHBS2 geneNull miceAffinity chromatographyGelatinolytic assaysThrombospondin-2TSP2Matrix metalloproteinase-2FibroblastsLevels of MMP2