2022
Genome-wide perturbations of Alu expression and Alu-associated post-transcriptional regulations distinguish oligodendroglioma from other gliomas
Hwang T, Kim S, Chowdhury T, Yu H, Kim K, Kang H, Won J, Park S, Shin J, Park C. Genome-wide perturbations of Alu expression and Alu-associated post-transcriptional regulations distinguish oligodendroglioma from other gliomas. Communications Biology 2022, 5: 62. PMID: 35042936, PMCID: PMC8766575, DOI: 10.1038/s42003-022-03011-w.Peer-Reviewed Original ResearchConceptsCircular RNA levelsI editingGenome-wide perturbationsPost-transcriptional processesPost-transcriptional regulationRNA expressionRNA levelsAlu expressionHuman genomeRNA-seqRegulatory elementsRepeat elementsGenetic elementsAlu subfamiliesBiological processesGrade 2 oligodendrogliomaAluExpressionGliomagenesisEditingUnique patternTranscriptomeGenomeSubfamiliesNormal tissues
2017
Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma
Kim S, Kim J, Kim Y, Hwang T, Kim S, Xu W, Shin J, Kim J, Choi H, Kim H, Cho H, Choi A, Chowdhury T, Seo Y, Dho Y, Kim J, Kim D, Park S, Kim H, Choi S, Park S, Lee S, Park C. Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma. Scientific Reports 2017, 7: 12221. PMID: 28939850, PMCID: PMC5610329, DOI: 10.1038/s41598-017-12557-3.Peer-Reviewed Original ResearchConceptsGlutaminase 2Subsequent metabolite profilingInsufficient NADPHKey genesRNA sequencingExpression profilingGene expressionFunctional analysisGenesExpression levelsMetabolite profilingGBM tissuesFluorescence heterogeneityMetabolic mechanismsNADPH production capacityFluorescence intensityAcid fluorescenceProfilingExpressionGlioblastoma treatmentProtoporphyrin IXFluorescenceIntratumoral heterogeneityFluorescence-guided surgeryTissue