2001
A GABA-neuropeptide Y (NPY) interplay in LH release
Horvath T, Pu S, Dube M, Diano S, Kalra S. A GABA-neuropeptide Y (NPY) interplay in LH release. Peptides 2001, 22: 473-481. PMID: 11287104, DOI: 10.1016/s0196-9781(01)00343-6.Peer-Reviewed Original ResearchConceptsGamma-amino butyric acidLH releaseNeurotransmitter/neuromodulatorExcitatory effectsArcuate nucleusReceptor agonistInhibitory gamma-amino butyric acidY4 receptor agonistRelease of LHImmunoreactive axon terminalsRat brain sectionsDose-dependent mannerOvarian steroidsOvariectomized ratsAxon terminalsBrain sectionsPrimary siteNPYMorphological findingsCyclic releaseAgonistsLHNeuromodulatorsRatsAdministration
1997
Lack of Gonadotropin-Positive Feedback in the Male Rat Is Associated with Lack of Estrogen-Induced Synaptic Plasticity in the Arcuate Nucleus
Horvath T, Garcia-Segura L, Naftolin F. Lack of Gonadotropin-Positive Feedback in the Male Rat Is Associated with Lack of Estrogen-Induced Synaptic Plasticity in the Arcuate Nucleus. Neuroendocrinology 1997, 65: 136-140. PMID: 9067991, DOI: 10.1159/000127173.Peer-Reviewed Original ResearchConceptsArcuate nucleusFemale ratsSynaptic plasticitySynaptic retractionMale ratsSynapse countsEstrogen-induced synaptic plasticityFemale arcuate nucleusVehicle-injected groupHypothalamic arcuate nucleusAdministration of estrogenAfternoon of proestrusQuantitative electron microscopic analysisOil-injected controlsGonadotropin secretionSynaptic reorganizationSynaptic countsConstant estrusEndogenous estrogensSynaptic remodelingSingle injectionTreatment groupsHormone injectionEstrogenOvarian cycle
1996
Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge.
Naftolin F, Mor G, Horvath TL, Luquin S, Fajer AB, Kohen F, Garcia-Segura LM. Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge. Endocrinology 1996, 137: 5576-80. PMID: 8940386, DOI: 10.1210/endo.137.12.8940386.Peer-Reviewed Original ResearchConceptsSynaptic retractionArcuate nucleusAxosomatic synapsesPreovulatory gonadotropinEstrous cycleMorning of metestrusPhysiological synaptic plasticitySurge of gonadotropinsMorning of estrusPreovulatory LH surgePreovulatory estradiolPreovulatory levelsLH surgeGonadotropin surgeHypothalamic mechanismsSynaptic remodelingEstrogen diethylstilbestrolSynaptic plasticityGonadotropinOvarian cycleControl femalesSynapsesPositive controlEstradiolEstrogenMorphological and pharmacological evidence for neuropeptide Y-galanin interaction in the rat hypothalamus
Horvath TL, Naftolin F, Leranth C, Sahu A, Kalra SP. Morphological and pharmacological evidence for neuropeptide Y-galanin interaction in the rat hypothalamus. Endocrinology 1996, 137: 3069-3077. PMID: 8770933, DOI: 10.1210/endo.137.7.8770933.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsArcuate Nucleus of HypothalamusAxonsCerebral VentriclesColchicineDendritesEstradiolEstrusFemaleGalaninHypothalamusHypothalamus, AnteriorImmunoenzyme TechniquesImmunohistochemistryLuteinizing HormoneMicroscopy, ImmunoelectronNeuronsNeuropeptide YOvariectomyParaventricular Hypothalamic NucleusPreoptic AreaProgesteroneRatsRats, Sprague-DawleySignal TransductionSubstance PSupraoptic NucleusConceptsNeuropeptide YMedial preoptic areaLH releaseGAL neuronsArcuate nucleusIntraventricular injectionParaventricular nucleusPreoptic areaSupraoptic nucleusSynaptic connectionsBasal LH releaseNPY-immunoreactive axonsPituitary hormone secretionPituitary gonadotropin releaseRelease of gonadotropinsMicroscopic examinationHypothalamic peptidergic systemsPeroxidase-antiperoxidase techniqueAvidin-biotin peroxidaseLight microscopic examinationMechanism of actionDiaminobenzidine reactionGAL releaseNPY inputNPY administration
1993
Role of neuropeptide-Y in episodic luteinizing hormone release in ovariectomized rats: an excitatory component and opioid involvement
Xu B, Sahu A, Crowley WR, Leranth C, Horvath T, Kalra SP. Role of neuropeptide-Y in episodic luteinizing hormone release in ovariectomized rats: an excitatory component and opioid involvement. Endocrinology 1993, 133: 747-754. PMID: 8344213, DOI: 10.1210/endo.133.2.8344213.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta-EndorphinCorticotropin-Releasing HormoneFemaleLuteinizing HormoneNaloxoneNeuropeptide YOvariectomyPeriodicityRatsConceptsEpisodic LH secretionPlasma LH levelsLH releaseLH secretionLH pulsesExcitatory componentLH levelsOVX ratsOvariectomized ratsMean plasma LH levelsAlpha-helical CRHBeta-endorphin neuronsInhibitory LH responseSuppression of LHLH pulse frequencyInfusion of naloxoneContinuous intraventricular infusionFrequency of LHRole of neuropeptidesNormal rabbit serumExogenous NPYNPY injectionLH responseIntracerebroventricular administrationIntraventricular administration
1992
Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis
Horvath TL, Naftolin F, Kalra SP, Leranth C. Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis. Endocrinology 1992, 131: 2461-2467. PMID: 1425443, DOI: 10.1210/endo.131.5.1425443.Peer-Reviewed Original ResearchConceptsPituitary LH releaseLH releaseOvariectomized ratsMediobasal hypothalamusSynaptic connectionsNPY-immunoreactive axonsBeta-endorphin systemSynaptic membrane specializationsRat mediobasal hypothalamusDirect synaptic connectionsDiaminobenzidine reactionLHRH neuronsNPY neuronsDual effectHypothalamic NPYLH secretionMedial basalLHRH secretionOvarian steroidsPrecise neural mechanismsFemale ratsAxon terminalsElectron microscopic examinationPeptidergic systemsNeuroendocrine regulation