Intranasal epidermal growth factor treatment rescues neonatal brain injury
Scafidi J, Hammond TR, Scafidi S, Ritter J, Jablonska B, Roncal M, Szigeti-Buck K, Coman D, Huang Y, McCarter RJ, Hyder F, Horvath TL, Gallo V. Intranasal epidermal growth factor treatment rescues neonatal brain injury. Nature 2013, 506: 230-234. PMID: 24390343, PMCID: PMC4106485, DOI: 10.1038/nature12880.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntranasalAnimalsAnimals, NewbornBrain InjuriesCell DifferentiationCell DivisionCell LineageCell SurvivalDemyelinating DiseasesDisease Models, AnimalEpidermal Growth FactorErbB ReceptorsHumansHypoxiaInfant, Premature, DiseasesMaleMiceMolecular Targeted TherapyOligodendrogliaRegenerationSignal TransductionStem CellsTime FactorsConceptsDiffuse white matter injuryNeonatal brain injuryVery preterm infantsWhite matter injuryOligodendrocyte precursor cellsEpidermal growth factor receptorGrowth factor treatmentGrowth factor receptorPreterm infantsFunctional recoveryBrain injurySuch injuriesEpidermal growth factor treatmentMouse modelFactor treatmentInjuryFactor receptorPrecursor cellsInfantsReceptorsRole of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning
Ozcan C, Palmeri M, Horvath TL, Russell KS, Russell RR. Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning. AJP Heart And Circulatory Physiology 2013, 304: h1192-h1200. PMID: 23457013, PMCID: PMC3652089, DOI: 10.1152/ajpheart.00592.2012.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsArrhythmias, CardiacCarbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCoronary OcclusionIn Vitro TechniquesIon ChannelsIschemic Preconditioning, MyocardialMaleMiceMice, Inbred C57BLMitochondrial ProteinsMyocardial InfarctionMyocardial Reperfusion InjuryMyocytes, CardiacReactive Oxygen SpeciesUncoupling Protein 2Uncoupling Protein 3Ventricular DysfunctionConceptsIschemia-reperfusion injuryR injuryIschemic preconditioningWT heartsMyocardial energeticsMouse heartsReactive oxygen speciesLeft coronary arteryLeft ventricular functionPostischemic functional recoveryWild-type mouse heartsUncoupling proteinDecreased ATP contentR arrhythmiasLarge infarctsVentricular functionFunctional recoveryWT miceCoronary arteryProtective efficacyCardioprotective efficacyMyocardial vulnerabilityVivo modelInjuryRole of UCPs