2006
Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals
Gao Q, Mezei G, Nie Y, Rao Y, Choi CS, Bechmann I, Leranth C, Toran-Allerand D, Priest CA, Roberts JL, Gao XB, Mobbs C, Shulman GI, Diano S, Horvath TL. Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nature Medicine 2006, 13: 89-94. PMID: 17195839, DOI: 10.1038/nm1525.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnorexiaArcuate Nucleus of HypothalamusBody WeightEstradiolEstrogen Receptor alphaExcitatory Postsynaptic PotentialsFemaleInjections, IntraventricularLeptinMaleMelanocortinsMiceMice, Inbred C57BLMice, KnockoutMice, ObeseMicroscopy, ElectronNeuronsObesityOvariectomyPro-OpiomelanocortinRatsRats, Sprague-DawleySignal TransductionSTAT3 Transcription FactorConceptsArcuate nucleusFood intakeLeptin receptor-deficient miceGonadal steroid estradiolRearrangement of synapsesReceptor-deficient miceBody weight regulationBody weight gainWild-type ratsPOMC neuronsLeptin effectsExcitatory inputsMetabolic hormonesLeptin receptorObese animalsSteroids estradiolWeight regulationBody weightSynaptic plasticityWeight gainRobust increaseInput organizationSTAT3 activationEnergy expenditureAdiposity
2001
Oestrogen‐Induced Changes in the Synaptology of the Monkey (Cercopithecus aethiops) Arcuate Nucleus During Gonadotropin Feedback
Zsarnovszky A, Horvath TL, Garcia‐Segura L, Horvath B, Naftolin F. Oestrogen‐Induced Changes in the Synaptology of the Monkey (Cercopithecus aethiops) Arcuate Nucleus During Gonadotropin Feedback. Journal Of Neuroendocrinology 2001, 13: 22-28. DOI: 10.1111/j.1365-2826.2001.00602.x.Peer-Reviewed Original ResearchConceptsGnRH neuronesGnRH cellsDay 1Day 2Day 8Pg/Gonadotropin secretionArcuate nucleusOestrogen-induced LH surgeAfrican green monkeysGonadotropin feedbackInhibitory innervationEstrogen modulationOVX monkeysLH surgeSerum concentrationsExcitatory inputsInhibitory synapsesExcitatory synapsesInhibitory inputsSynaptic connectionsGnRHNeuronesGreen monkeysSynapsesOestrogen-induced changes in the synaptology of the monkey (Cercopithecus aethiops) arcuate nucleus during gonadotropin feedback.
Zsarnovszky A, Horvath T, Garcia-Segura L, Horvath B, Naftolin F. Oestrogen-induced changes in the synaptology of the monkey (Cercopithecus aethiops) arcuate nucleus during gonadotropin feedback. Journal Of Neuroendocrinology 2001, 13: 22-8. PMID: 11123512, DOI: 10.1046/j.1365-2826.2001.00602.x.Peer-Reviewed Original ResearchConceptsGnRH neuronesGnRH cellsDay 1Day 2Day 8Pg/Gonadotropin secretionOestrogen-induced LH surgeAfrican green monkeysInhibitory innervationEstrogen modulationOVX monkeysLH surgeArcuate nucleusSerum concentrationsExcitatory inputsInhibitory synapsesExcitatory synapsesInhibitory inputsSynaptic connectionsGnRHNeuronesGreen monkeysSynapsesPronounced alterations