2024
3-Hydroxykynurenine targets kainate receptors to promote defense against infection
Parada-Kusz M, Clatworthy A, Goering E, Blackwood S, Shigeta J, Mashin E, Salm E, Choi C, Combs S, Lee J, Rodriguez-Osorio C, Clish C, Tomita S, Hung D. 3-Hydroxykynurenine targets kainate receptors to promote defense against infection. Nature Chemical Biology 2024, 1-11. PMID: 38898166, DOI: 10.1038/s41589-024-01635-z.Peer-Reviewed Original ResearchKainate-sensitive glutamate receptorsHost tryptophan metabolismHost survivalBacterial infectionsPromote host survivalGlutamate receptorsLethal bacterial infectionHost-pathogenIn vivo chemical screeningTryptophan metabolismPromote defenseBacterial expansionOutcome of infectionChemical screeningZebrafish embryosAntibacterial activityKainate receptorsPathogen eradicationPathogensHostModulate immunityNervous systemInfectionMetabolismReceptors
2023
Glutamatergic Pathways and Receptors
Tomita S. Glutamatergic Pathways and Receptors. 2023, 197-200. DOI: 10.1007/978-3-031-15070-8_30.Peer-Reviewed Original ResearchGlutamate receptorsSynaptic transmissionSynaptic plasticityReceptor activityGlutamate receptor activityGlutamate-gated cation channelsMajor excitatory neurotransmitterGi/oG protein-coupled receptorsProtein-coupled receptorsGlutamate releaseExcitatory neurotransmitterNMDA receptorsGlutamatergic pathwaysKainate receptorsAMPA receptorsTherapeutic strategiesDistinct synapsesPostsynaptic signalingNeurological disordersSynaptic strengthGq signalingNeurodegenerative diseasesReceptorsCation channels
2016
Glutamatergic Pathways and Receptors
Tomita S. Glutamatergic Pathways and Receptors. 2016, 231-236. DOI: 10.1007/978-3-319-24551-5_29.Peer-Reviewed Original ResearchGlutamate receptorsSynaptic transmissionSynaptic plasticityReceptor activityGlutamate receptor activityGlutamate-gated cation channelsMajor excitatory neurotransmitterGi/oG protein-coupled receptorsProtein-coupled receptorsGlutamate releaseExcitatory neurotransmitterNMDA receptorsGlutamatergic pathwaysKainate receptorsAMPA receptorsTherapeutic strategiesDistinct synapsesPostsynaptic signalingNeurological disordersSynaptic strengthGq signalingNeurodegenerative diseasesReceptorsCation channels
2011
Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1
Straub C, Hunt DL, Yamasaki M, Kim KS, Watanabe M, Castillo PE, Tomita S. Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1. Nature Neuroscience 2011, 14: 866-873. PMID: 21623363, PMCID: PMC3125417, DOI: 10.1038/nn.2837.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBiophysical PhenomenaBiophysicsCA1 Region, HippocampalCell Line, TransformedCerebellumDisks Large Homolog 4 ProteinDizocilpine MaleateDose-Response Relationship, DrugDrug InteractionsElectric StimulationExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGene Expression RegulationGreen Fluorescent ProteinsGuanylate KinasesHumansImmunoprecipitationIn Vitro TechniquesIntracellular Signaling Peptides and ProteinsKainic AcidLDL-Receptor Related ProteinsLipoproteins, LDLMembrane PotentialsMembrane ProteinsMiceMice, KnockoutNeuronsPatch-Clamp TechniquesPresynaptic TerminalsProtein BindingProtein SubunitsReceptors, Kainic AcidReceptors, N-Methyl-D-AspartateSynaptophysinTransfectionTritium
2009
A Transmembrane Accessory Subunit that Modulates Kainate-Type Glutamate Receptors
Zhang W, St-Gelais F, Grabner CP, Trinidad JC, Sumioka A, Morimoto-Tomita M, Kim KS, Straub C, Burlingame AL, Howe JR, Tomita S. A Transmembrane Accessory Subunit that Modulates Kainate-Type Glutamate Receptors. Neuron 2009, 61: 385-396. PMID: 19217376, PMCID: PMC2803770, DOI: 10.1016/j.neuron.2008.12.014.Peer-Reviewed Original ResearchConceptsKainate-type glutamate receptorsGlutamate receptorsIonotropic glutamate receptorsKainate receptorsSynaptic transmissionSurface expressionNative kainate receptorsFast synaptic transmissionKainate receptor subunitsBrain-specific proteinsExcitatory transmissionNMDA receptorsAMPA receptorsReceptor subunitsReceptorsProtein levelsNETO2Auxiliary subunitsTARP auxiliary subunitsBrainVertebrate brainKainate receptor GluR6Proteomic screenMajor roleMEPSCs