2022
Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats
Villiamma P, Casby J, Groman SM. Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats. Psychopharmacology 2022, 239: 2885-2901. PMID: 35705734, PMCID: PMC10332493, DOI: 10.1007/s00213-022-06174-w.Peer-Reviewed Original ResearchConceptsCocaine-taking behaviorReversal-learning performanceDecision-making functionsReversal-learning taskReinforcement learning modelIndividual differencesAdolescent developmentFemale Long-Evans ratsRewarded outcomesDevelopmental trajectoriesNeurobiological mechanismsAdolescent trajectoriesAge-related changesGreater cocaineBiobehavioral mechanismsNeural adaptationLong-Evans ratsPredictive relationshipAddiction susceptibilityAdolescenceChoice behaviorAdulthoodDecision-making trajectoriesMental illnessChoice data
2020
Introducing the PLOS ONE Collection on the neuroscience of reward and decision making
Groman SM, Ikemoto S, Rushworth M, Taylor JR, Whelan R. Introducing the PLOS ONE Collection on the neuroscience of reward and decision making. PLOS ONE 2020, 15: e0240505. PMID: 33031482, PMCID: PMC7544023, DOI: 10.1371/journal.pone.0240505.Peer-Reviewed Original ResearchConceptsAction-outcome associationsDecision-making deficitsPast experienceDecision makingNeuroscience techniquesNeurobiological mechanismsBehavioral approachNovel inferencesAdaptive decisionDecision-making functionsMechanistic linkParticular actionNeuroscienceAlternative outcomesBiological mechanismsOrganismsComputational functionsRewardNew insightsParticular outcomeNew environmentRecent advancesPredatorsMakingBiologyMidbrain D3 Receptor Availability Predicts Escalation in Cocaine Self-administration
Groman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Midbrain D3 Receptor Availability Predicts Escalation in Cocaine Self-administration. Biological Psychiatry 2020, 88: 767-776. PMID: 32312578, PMCID: PMC8954711, DOI: 10.1016/j.biopsych.2020.02.017.Peer-Reviewed Original ResearchConceptsProbabilistic reversalTests of extinctionSubstance-dependent individualsCue-induced reinstatementRelapse-like behaviorTest of motivationAddiction-like behaviorCocaine self-administration behaviorCocaine-taking behaviorReceptor availabilitySelf-administer cocaineIndividual differencesAddicted populationNeurobiological mechanismsSelf-administration behaviorGreater escalationGreater motivationPoor decisionsNeural adaptationD3 receptor availabilityCocaine Self-AdministrationBehavioral biomarkersDecision-making functionsChoice behaviorRate of escalation