Restoration of tumor specific human leukocyte antigens class I-restricted cytotoxicity by dendritic cell stimulation of tumor infiltrating lymphocytes in patients with advanced ovarian cancer
SANTIN A, BELLONE S, PALMIERI M, BOSSINI B, CANE S, BIGNOTTI E, ROMAN J, CANNON M, PECORELLI S. Restoration of tumor specific human leukocyte antigens class I-restricted cytotoxicity by dendritic cell stimulation of tumor infiltrating lymphocytes in patients with advanced ovarian cancer. International Journal Of Gynecological Cancer 2004, 14: 64-75. DOI: 10.1111/ijgc-00009577-200401000-00008.Peer-Reviewed Original ResearchCD8+ T cellsAdvanced ovarian cancerPeripheral blood lymphocytesAdvanced ovarian cancer patientsTumor-infiltrating lymphocytesTumor infiltrationOvarian cancer patientsCytotoxic T lymphocytesDendritic cell stimulationOvarian cancerT cellsLymphoblastoid cell linesInfiltrating lymphocytesDendritic cellsKilling of autologous tumor cellsTumor-specific cytotoxic T lymphocytesTumor-specific T-cell responsesAnti-HLA class I mAbCD8+ T cell populationsCancer patientsAutologous ovarian cancer cellsAutologous tumor target cellsCD8+ CTL responsesLevels of CD56 expressionTumor antigen-loaded DC