2020
Stages of major depressive disorder and behavioral multi-morbidities: Findings from nationally representative epidemiologic study
Rhee TG, Mohamed S, Rosenheck RA. Stages of major depressive disorder and behavioral multi-morbidities: Findings from nationally representative epidemiologic study. Journal Of Affective Disorders 2020, 278: 443-452. PMID: 33010569, DOI: 10.1016/j.jad.2020.09.081.Peer-Reviewed Original ResearchConceptsChronic major depressive disorderMajor depressive disorderNew-onset major depressive disorderOnset major depressive disorderBorderline personality disorderDepressive disorderUse disordersRepresentative cross-sectional surveyRepresentative epidemiologic studyPersonality disorderMore psychiatric disordersSubstance use disordersAlcohol use disorderNational Epidemiologic SurveyRelated Conditions-IIICross-sectional surveyDSM-5 diagnostic criteriaMultivariable analysisGroup of adultsEpidemiologic studiesUS adultsDiagnostic criteriaPsychiatric disordersEpidemiologic SurveyMDD history
2016
Characteristics of U.S. Veteran Patients with Major Depressive Disorder who require “next-step” treatments: A VAST-D report
Zisook S, Tal I, Weingart K, Hicks P, Davis LL, Chen P, Yoon J, Johnson GR, Vertrees JE, Rao S, Pilkinton PD, Wilcox JA, Sapra M, Iranmanesh A, Huang GD, Mohamed S. Characteristics of U.S. Veteran Patients with Major Depressive Disorder who require “next-step” treatments: A VAST-D report. Journal Of Affective Disorders 2016, 206: 232-240. PMID: 27479536, DOI: 10.1016/j.jad.2016.07.023.Peer-Reviewed Original ResearchConceptsMajor depressive disorderClinical featuresDepressive disorderNonpsychotic major depressive disorderInitial standard treatmentNon-veteran samplesU.S. veteran patientsCharacteristics of patientsSample of veteransRecent suicidal ideationPublic health imperativeLasting treatmentMDD treatmentVeteran patientsClinical onsetPsychiatric comorbidityAntidepressant trialsStandard treatmentClinical trialsDepression subtypesRecurrent depressionIndividual patientsSpecific treatmentPatientsSuicidal ideation
2015
Randomized Trial of the Effect of Four Second-Generation Antipsychotics and One First-Generation Antipsychotic on Cigarette Smoking, Alcohol, and Drug Use in Chronic Schizophrenia
Mohamed S, Rosenheck RA, Lin H, Swartz M, McEvoy J, Stroup S. Randomized Trial of the Effect of Four Second-Generation Antipsychotics and One First-Generation Antipsychotic on Cigarette Smoking, Alcohol, and Drug Use in Chronic Schizophrenia. The Journal Of Nervous And Mental Disease 2015, 203: 486-492. PMID: 26075840, DOI: 10.1097/nmd.0000000000000317.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlcoholismAntipsychotic AgentsBenzodiazepinesChronic DiseaseComorbidityCross-Sectional StudiesDibenzothiazepinesDouble-Blind MethodFemaleHumansIllicit DrugsMaleMiddle AgedOlanzapinePerphenazinePiperazinesPsychiatric Status Rating ScalesQuetiapine FumarateRisperidoneSchizophreniaSchizophrenic PsychologySmokingSmoking PreventionSubstance-Related DisordersThiazolesYoung AdultConceptsSecond-generation antipsychotic drugsAntipsychotic drugsFirst-generation antipsychoticsSecond-generation antipsychoticsIntervention Effectiveness (CATIE) studySecondary outcome dataClinical Antipsychotic TrialsFirst-generation drugsSubstance use outcomesCigarette smokingSchizophrenia trialsChronic schizophreniaAntipsychotic TrialsOutcome dataNicotine useDrug useSecondary analysisPast weekAntipsychoticsEffectiveness studiesPatientsSubstance useUse outcomesTrialsDrugs
2012
Does Antidepressant Treatment Improve Cognition in Older People with Schizophrenia or Schizoaffective Disorder and Comorbid Subsyndromal Depression?
Dawes SE, Palmer BW, Meeks T, Golshan S, Kasckow J, Mohamed S, Zisook S. Does Antidepressant Treatment Improve Cognition in Older People with Schizophrenia or Schizoaffective Disorder and Comorbid Subsyndromal Depression? Neuropsychobiology 2012, 65: 168-172. PMID: 22456094, PMCID: PMC3701889, DOI: 10.1159/000331141.Peer-Reviewed Original ResearchConceptsSchizoaffective disorderCognitive deficitsDepression Rating Scale scoresHamilton Depression Rating ScaleFlexible-dose treatmentAntidepressant treatment responseDepression Rating ScaleTreatment of depressionMajor depressive disorderRating Scale scoresBaseline cognitive statusPlacebo groupAntidepressant medicationCurrent medicationsPlacebo augmentationFunctional disabilityCognitive composite scoreSubsyndromal depressionDepressive disorderSubsyndromal symptomsTreatment responseTreatment groupsDose treatmentScale scoreCognitive status
2010
Impact of second-generation antipsychotics and perphenazine on depressive symptoms in a randomized trial of treatment for chronic schizophrenia.
Addington DE, Mohamed S, Rosenheck RA, Davis SM, Stroup TS, McEvoy JP, Swartz MS, Lieberman JA. Impact of second-generation antipsychotics and perphenazine on depressive symptoms in a randomized trial of treatment for chronic schizophrenia. The Journal Of Clinical Psychiatry 2010, 72: 75-80. PMID: 20868641, PMCID: PMC5052810, DOI: 10.4088/jcp.09m05258gre.Peer-Reviewed Original ResearchConceptsMajor depressive episodeSecond-generation antipsychoticsDSM-IV-defined schizophreniaCurrent major depressive episodeClinical practice recommendationsTrial of treatmentClinical practice guidelinesTreatment of depressionCalgary Depression ScaleClinical Antipsychotic TrialsSecond-generation drugsSymptoms of depressionPhase 1 analysisTardive dyskinesiaDepressive episodeChronic schizophreniaAntipsychotic TrialsPractice guidelinesDepression ScaleDepressive symptomsTreatment groupsBaseline scoresPatientsAntipsychoticsPractice recommendationsTransition to Low Intensity Case Management in a VA Assertive Community Treatment Model Program
Rosenheck RA, Neale MS, Mohamed S. Transition to Low Intensity Case Management in a VA Assertive Community Treatment Model Program. Psychiatric Rehabilitation Journal 2010, 33: 288-296. PMID: 20374987, DOI: 10.2975/33.4.2010.288.296.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismCaregiversCombined Modality TherapyCommunity Mental Health ServicesComorbidityDiagnosis, Dual (Psychiatry)FemaleHospitalizationHumansIndependent LivingMaleMental DisordersMiddle AgedOutcome and Process Assessment, Health CarePatient Care TeamPsychotic DisordersQuality of LifeRehabilitation, VocationalSelf CareSocial AdjustmentSocial SupportSubstance-Related DisordersUnited StatesUnited States Department of Veterans AffairsUtilization ReviewVeteransConceptsLower intensity servicesAssertive community treatmentService useLow-intensity treatmentNational VA administrative dataIntensive case management programSubsequent service useBaseline clinical characteristicsGreater clinical improvementMonths of treatmentVA administrative dataYears of treatmentLogistic regression analysisEarly clinical changesMonths of participationHigh-intensity servicesCase management programClinical improvementClinical characteristicsClinical changesVeteran characteristicsCommunity treatmentBivariate comparisonsCase managementGood family relationships
2009
VA intensive mental health case management in urban and rural areas: veteran characteristics and service delivery.
Mohamed S, Neale M, Rosenheck RA. VA intensive mental health case management in urban and rural areas: veteran characteristics and service delivery. Psychiatric Services 2009, 60: 914-21. PMID: 19564221.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAlcoholismCase ManagementCommunity Mental Health ServicesComorbidityCross-Sectional StudiesDelivery of Health CareDisability EvaluationFemaleHealth Services AccessibilityHealthcare DisparitiesHumansMaleMental DisordersMiddle AgedRural PopulationSocioeconomic FactorsSubstance-Related DisordersUnited StatesUrban PopulationVeteransConceptsNational VA administrative dataVeterans AffairsCase managementRural-Urban Commuting Area codesIntensive case management servicesVA administrative dataAssertive community treatmentCharacteristics of veteransIntensive case managementMental health servicesMental health case managementCase management servicesRecovery-oriented servicesRural veteransVA disability compensationVeteran characteristicsDisability compensationRural areasClinical problemCommunity treatmentHealth servicesMental illnessService deliveryVeteransAdministrative dataUse of antipsychotics in the treatment of major depressive disorder in the U.S. Department of Veterans Affairs.
Mohamed S, Leslie DL, Rosenheck RA. Use of antipsychotics in the treatment of major depressive disorder in the U.S. Department of Veterans Affairs. The Journal Of Clinical Psychiatry 2009, 70: 906-12. PMID: 19422760, DOI: 10.4088/jcp.08m04450.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAntidepressive AgentsAntipsychotic AgentsComorbidityDepressive Disorder, MajorDose-Response Relationship, DrugDrug Therapy, CombinationDrug UtilizationFemaleHospitals, VeteransHumansMaleMiddle AgedUnited StatesUnited States Food and Drug AdministrationVeteransConceptsMajor depressive disorderTreatment of MDDAntipsychotic medicationDepressive disorderService useMental health service useVeterans Affairs patientsUse of antipsychoticsHealth service useComorbid mental illnessDrug Administration approvalLong-term safetyRecent U.S. FoodFirst antipsychoticAntipsychotic dosesAntipsychotic prescriptionsPsychiatric comorbidityComorbid schizophreniaMale genderAdministration approvalVeteran characteristicsMedicationsSchizoaffective disorderAntipsychoticsBipolar disorder
2008
Pharmacologic Treatment of Posttraumatic Stress Disorder Among Privately Insured Americans
Harpaz-Rotem I, Rosenheck RA, Mohamed S, Desai RA. Pharmacologic Treatment of Posttraumatic Stress Disorder Among Privately Insured Americans. Psychiatric Services 2008, 59: 1184-1190. PMID: 18832505, DOI: 10.1176/ps.2008.59.10.1184.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPsychotropic medicationsMedication classesStress disorderTreatment of PTSDMental health care usersSymptom-specific responsesComorbid psychiatric disordersUse of anxiolyticsMultivariate logistic regressionDiagnosis of PTSDMajor depressive disorderMental health servicesHealth care usersMedication usePharmacologic treatmentAntidepressant useHealth insurance plansMarketScan databaseAntipsychotic usePrivate health insurance plansPharmacological treatmentDepressive disorderSpecific symptomsMillions of AmericansPharmacotherapy of PTSD in the U.S. Department of Veterans Affairs: diagnostic- and symptom-guided drug selection.
Mohamed S, Rosenheck RA. Pharmacotherapy of PTSD in the U.S. Department of Veterans Affairs: diagnostic- and symptom-guided drug selection. The Journal Of Clinical Psychiatry 2008, 69: 959-65. PMID: 18588361, DOI: 10.4088/jcp.v69n0611.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Anxiety AgentsAntipsychotic AgentsAnxietyComorbidityDrug TherapyFemaleHumansHypnotics and SedativesInternational Classification of DiseasesMaleMiddle AgedPsychotropic DrugsSleep Initiation and Maintenance DisordersStress Disorders, Post-TraumaticUnited StatesUnited States Department of Veterans AffairsConceptsPosttraumatic stress disorderAnxiolytic/Psychotropic medicationsVeterans AffairsMedication classesService usePharmacotherapy of PTSDMental health service useTreatment of PTSDGreater mental health service usePsychotropic medication classesSedative-hypnotic useHealth service useMultivariable logistic regressionAntidepressant useMedication usePsychotropic prescriptionsAntipsychotic useSuch medicationsVA patientsPsychotropic pharmacotherapySymptom responseDepressive disorderVeteran characteristicsSpecific symptoms
2007
Subsyndromal Depressive Symptoms in Middle-Aged and Older Persons with Schizophrenia
Zisook S, Montross L, Kasckow J, Mohamed S, Palmer BW, Patterson TL, Golshan S, Fellows I, Lehman D, Solorzano E. Subsyndromal Depressive Symptoms in Middle-Aged and Older Persons with Schizophrenia. American Journal Of Geriatric Psychiatry 2007, 15: 1005-1014. PMID: 18056819, DOI: 10.1097/jgp.0b013e3180a725ec.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsChronic DiseaseCitalopramComorbidityDepressionDepressive Disorder, MajorDouble-Blind MethodFemaleFollow-Up StudiesHealth StatusHumansMaleMiddle AgedPlacebosPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologySelective Serotonin Reuptake InhibitorsSuicideTreatment OutcomeConceptsSubsyndromal depressive symptomsDepressive symptomsOlder patientsClinical featuresSchizoaffective disorderNegative symptomsHamilton Depression Rating ScaleImportant clinical dimensionGeneral medical conditionsDepression Rating ScaleSpecific depressive symptomsMental functioningSubstantial morbiditySevere akathisiaMovement abnormalitiesChronic schizophreniaMedical conditionsDepression groupOverall psychopathologyIntervention studiesDepressive symptomatologyPatientsSymptomsOlder personsGeneral psychopathology
2005
Review of assessment and treatment of PTSD among elderly American armed forces veterans
Owens GP, Baker DG, Kasckow J, Ciesla JA, Mohamed S. Review of assessment and treatment of PTSD among elderly American armed forces veterans. International Journal Of Geriatric Psychiatry 2005, 20: 1118-1130. PMID: 16315160, DOI: 10.1002/gps.1408.Peer-Reviewed Original ResearchConceptsTreatment of PTSDPosttraumatic stress disorderElderly veteran populationVeteran populationElderly veteransPharmacological interventionsElderly combat veteransPharmacological treatment interventionsPilot databaseArmed forces veteransSupportive therapyPsychological comorbiditiesElderly populationTreatment interventionsSomatic symptomsCognitive deficitsReview of assessmentExposure therapySubstance abuseLiterature searchStress disorderYoung individualsLimited dataVeteransCombat veterans