2013
Adding antidepressants to antipsychotics for treatment of subsyndromal depressive symptoms in schizophrenia: Impact on positive and negative symptoms
Vahia IV, Lanouette NM, Golshan S, Fellows I, Mohamed S, Kasckow JW, Zisook S. Adding antidepressants to antipsychotics for treatment of subsyndromal depressive symptoms in schizophrenia: Impact on positive and negative symptoms. Indian Journal Of Psychiatry 2013, 55: 144-148. PMID: 23825848, PMCID: PMC3696237, DOI: 10.4103/0019-5545.111452.Peer-Reviewed Original ResearchAnti-psychotic medicationSubsyndromal depressionNegative symptomsDepressive symptomsSchizoaffective disorderNegative Syndrome Scale (PANSS) scoresPANSS negative symptom scoreFlexible-dose treatmentSchizophrenia/schizoaffective disorderSubsyndromal depressive symptomsPANSS positive scoreNegative symptom scoresAntidepressant augmentationPlacebo augmentationSymptom scoresCitalopram groupStudy criteriaTreatment groupsAnalysis of covarianceScale scoreSymptomsCitalopramSchizophreniaPositive scoreMedications
2008
Citalopram augmentation for subsyndromal symptoms of depression in middle-aged and older outpatients with schizophrenia and schizoaffective disorder: a randomized controlled trial.
Zisook S, Kasckow JW, Golshan S, Fellows I, Solorzano E, Lehman D, Mohamed S, Jeste DV. Citalopram augmentation for subsyndromal symptoms of depression in middle-aged and older outpatients with schizophrenia and schizoaffective disorder: a randomized controlled trial. The Journal Of Clinical Psychiatry 2008, 70: 562-71. PMID: 19192468, DOI: 10.4088/jcp.08m04261.Peer-Reviewed Original ResearchConceptsQuality of lifeSubsyndromal symptomsSchizoaffective disorderOlder patientsOlder outpatientsTreatment groupsRandomized placebo-controlled trialRating ScaleFlexible-dose treatmentSecondary efficacy analysesPlacebo-controlled trialCurrent antipsychotic medicationsDepression Rating ScaleGeneral medical healthHamilton Rating ScaleCalgary Depression Rating ScaleYears of ageDSM-IV schizophreniaCitalopram augmentationAdverse eventsPlacebo augmentationEfficacy analysisAntipsychotic medicationStudy criteriaDimensions of schizophrenia