2013
Adding antidepressants to antipsychotics for treatment of subsyndromal depressive symptoms in schizophrenia: Impact on positive and negative symptoms
Vahia IV, Lanouette NM, Golshan S, Fellows I, Mohamed S, Kasckow JW, Zisook S. Adding antidepressants to antipsychotics for treatment of subsyndromal depressive symptoms in schizophrenia: Impact on positive and negative symptoms. Indian Journal Of Psychiatry 2013, 55: 144-148. PMID: 23825848, PMCID: PMC3696237, DOI: 10.4103/0019-5545.111452.Peer-Reviewed Original ResearchAnti-psychotic medicationSubsyndromal depressionNegative symptomsDepressive symptomsSchizoaffective disorderNegative Syndrome Scale (PANSS) scoresPANSS negative symptom scoreFlexible-dose treatmentSchizophrenia/schizoaffective disorderSubsyndromal depressive symptomsPANSS positive scoreNegative symptom scoresAntidepressant augmentationPlacebo augmentationSymptom scoresCitalopram groupStudy criteriaTreatment groupsAnalysis of covarianceScale scoreSymptomsCitalopramSchizophreniaPositive scoreMedications
2010
Augmentation with citalopram for suicidal ideation in middle-aged and older outpatients with schizophrenia and schizoaffective disorder who have subthreshold depressive symptoms: a randomized controlled trial.
Zisook S, Kasckow JW, Lanouette NM, Golshan S, Fellows I, Vahia I, Mohamed S, Rao S. Augmentation with citalopram for suicidal ideation in middle-aged and older outpatients with schizophrenia and schizoaffective disorder who have subthreshold depressive symptoms: a randomized controlled trial. The Journal Of Clinical Psychiatry 2010, 71: 915-22. PMID: 20361918, DOI: 10.4088/jcp.09m05699gre.Peer-Reviewed Original ResearchConceptsBaseline suicidal ideationHamilton Depression Rating ScaleDepression Rating ScaleSubthreshold depressive symptomsCalgary Depression Rating ScaleDepressive symptomsSuicidal ideationSchizoaffective disorderClinical Global Impressions-SeverityBeck Hopelessness ScaleDSM-IV-diagnosed schizophreniaRating ScaleTreatment-emergent suicidal ideationPlacebo-controlled trialSuicidal ideation measuresItem 3Citalopram augmentationFinal visitPlacebo augmentationSecondary outcomesPrimary outcomeOlder outpatientsInterSePT ScaleCitalopramPlacebo