2023
Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral, and Neurobiological Domains Among Youth
Kohler R, Lichenstein S, Cheng A, Holmes A, Bzdok D, Pearlson G, Yip S. Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral, and Neurobiological Domains Among Youth. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 407-416. PMID: 38052266, PMCID: PMC11149944, DOI: 10.1016/j.bpsc.2023.11.008.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderDisruptive behavior disordersAnterior cingulate responsesLatent dimensionsAnticipatory reward processingDeficit hyperactivity disorderSingle latent dimensionRisk-taking behaviorNegative urgencyExecutive functionIndividual differencesNeurobiological domainsReward anticipationCingulate responseReward processingAdolescent brainCognitive developmentNeural substratesHyperactivity disorderDevelopmental trajectoriesEarly adolescenceMultivariate patternsReward processesBehavioral variablesBehavior disorder
2019
Dissociable neural substrates of opioid and cocaine use identified via connectome-based modelling
Lichenstein SD, Scheinost D, Potenza MN, Carroll KM, Yip SW. Dissociable neural substrates of opioid and cocaine use identified via connectome-based modelling. Molecular Psychiatry 2019, 26: 4383-4393. PMID: 31719641, PMCID: PMC7214212, DOI: 10.1038/s41380-019-0586-y.Peer-Reviewed Original ResearchConceptsBrain statesDissociable neural substratesMultiple brain statesSubstance use outcomesHealthy comparison subjectsWhole-brain approachFMRI scanningFrontoparietal networkNeural substratesSubstance use treatmentNeural mechanismsDifferent brain statesFurther clinical relevanceDefault modeFMRI dataSubject replicationTreatment approachesReduced connectivityUse outcomesComparison subjectsNetwork strengthUse disordersSensory networksTreatment respondersSensory connectivity