2020
Chronic mTOR activation induces a degradative smooth muscle cell phenotype
Li G, Wang M, Caulk AW, Cilfone NA, Gujja S, Qin L, Chen PY, Chen Z, Yousef S, Jiao Y, He C, Jiang B, Korneva A, Bersi MR, Wang G, Liu X, Mehta S, Geirsson A, Gulcher JR, Chittenden TW, Simons M, Humphrey JD, Tellides G. Chronic mTOR activation induces a degradative smooth muscle cell phenotype. Journal Of Clinical Investigation 2020, 130: 1233-1251. PMID: 32039915, PMCID: PMC7269581, DOI: 10.1172/jci131048.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAortic Aneurysm, ThoracicAortic DissectionBeta CateninDisease Models, AnimalLysosomesMechanistic Target of Rapamycin Complex 1MiceMice, Knockout, ApoEMicrophthalmia-Associated Transcription FactorMyocytes, Smooth MuscleSignal TransductionTOR Serine-Threonine KinasesTuberous Sclerosis Complex 1 ProteinConceptsMTOR activationMTOR complex 1Smooth muscle cell phenotypeMuscle cell phenotypeContext of hyperlipidemiaSmooth muscle cell proliferationThoracic aortic aneurysmDegradative organellesMuscle cell proliferationHematopoietic lineage markersSMC phenotypeLysosomal clearanceAdvanced diseaseMedial degenerationAortic diseaseLysosomal markersAortic aneurysmExtracellular matrixPhenotypic modulationConventional macrophagesMacrophage markersMedial SMCsConditional disruptionLineage markersImmune effectors
2019
Genomic sites hypersensitive to ultraviolet radiation
Premi S, Han L, Mehta S, Knight J, Zhao D, Palmatier MA, Kornacker K, Brash DE. Genomic sites hypersensitive to ultraviolet radiation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 24196-24205. PMID: 31723047, PMCID: PMC6883822, DOI: 10.1073/pnas.1907860116.Peer-Reviewed Original ResearchMeSH Keywords5' Untranslated RegionsCells, CulturedDNA DamageFibroblastsGene Expression RegulationGenome, HumanHigh-Throughput Nucleotide SequencingHumansMelanocytesMelanomaMutationPromoter Regions, GeneticProtein BiosynthesisPyrimidine DimersPyrimidine NucleotidesSkin NeoplasmsTOR Serine-Threonine KinasesUltraviolet RaysConceptsCyclobutane pyrimidine dimersETS family transcription factorsIndividual gene promotersFamily transcription factorsRNA-binding proteinPrimary human melanocytesSingle-base resolutionEpigenetic marksGenomic averageTranslation regulationGenomic sitesMotif locationsTranscription factorsCell physiologyGene promoterCancer driversGenomeHuman melanocytesCell typesTumor evolutionCell pathwaysRare mutationsUV targetPyrimidine dimersApurinic sites