Salih Cayir, MD
he/him/his
Postdoctoral AssociateDownloadHi-Res Photo
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Yale School of Medicine
801 Howard Ave
New Haven, Connecticut 06510
United States
About
Titles
Postdoctoral Associate
Biography
I'm a medical graduate (M.D.) from Istanbul University, Türkiye, with a focus on clinically translational research aimed at finding new diagnostic and treatment options for a range of addictive and neuropsychiatric disorders, including frontotemporal dementia, opioid use disorder, and Parkinson's disease. My research utilizes cutting-edge PET imaging techniques to investigate the role of key neuroreceptors, including synaptic density (SV2A), dopamine D3, mGluR5, and kappa opioid systems, in these clinical conditions. My work also focuses on investigating how environmental factors influence brain neurotransmitter systems and their connection to neuropsychiatric disorders, intending to bridge scientific discovery and clinical practice.
Education & Training
- MD
- Istanbul University School of Medicine (2024)
Research
Overview
Medical Research Interests
Frontotemporal Dementia; Geriatric Psychiatry; Neurodegenerative Diseases; Parkinson Disease
Public Health Interests
Environmental Health
ORCID
0000-0002-4071-5188
Research at a Glance
Yale Co-Authors
Frequent collaborators of Salih Cayir's published research.
David Matuskey, MD
Adam Mecca, MD, PhD
Arman Fesharaki-Zadeh, MD, PhD, BMath
Jean-Dominique Gallezot, PhD
Melissa C Funaro, MLS, MS
Takuya Toyonaga, MD, PhD
Publications
2024
Socioenvironmental Factors are Associated With Dopamine Transporter Availability in Healthy Individuals but not in Parkinson's Disease.
Cayir S, Tezel M, Matuskey D. Socioenvironmental Factors are Associated With Dopamine Transporter Availability in Healthy Individuals but not in Parkinson's Disease. Journal Of Geriatric Psychiatry And Neurology 2024, 8919887241281062. PMID: 39244698, DOI: 10.1177/08919887241281062.Peer-Reviewed Original ResearchAltmetricConceptsMedian household incomeDopaminergic functionHealthy individualsSocioenvironmental factorsEducation levelHousehold incomeZIP Code Tabulation AreasBrain dopaminergic functionDopamine transporter availabilityResidential zip codeParkinson's Progression Markers InitiativeParkinson's diseaseNo significant associationAmerican Community SurveyDAT availabilityDopamine transporterZip codesClinical dataHealthy subjectsSocioenvironmental variablesCommunity SurveySignificant associationPD groupPoverty ratesStudy findingsA review of the kappa opioid receptor system in opioid use
Cayir S, Zhornitsky S, Barzegary A, Sotomayor-Carreño E, Sarfo-Ansah W, Funaro M, Matuskey D, Angarita G. A review of the kappa opioid receptor system in opioid use. Neuroscience & Biobehavioral Reviews 2024, 162: 105713. PMID: 38733895, DOI: 10.1016/j.neubiorev.2024.105713.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricConceptsKappa opioid receptor systemKappa-opioid receptorsOUD subjectsKappa-opioid receptor expressionOpioid withdrawal symptomsWithdrawal symptomsDynorphin levelsPeripheral blood lymphocytesOpioid useDrug-seeking/taking behaviorAnti-reward systemsKappa-opioid receptor antagonistClinical studiesCerebrospinal fluidOpioid receptor systemKOR/dynorphin systemDisorder subjectsOpioid receptorsOpioid intoxicationBlood lymphocytesReceptor systemOpioidWeb of ScienceClinical roleDynorphinRelationship between neuroimaging and cognition in frontotemporal dementia: An FDG‐PET and structural MRI study
Cayir S, Volpi T, Toyonaga T, Gallezot J, Yang Y, Sadabad F, Mulnix T, Mecca A, Fesharaki‐Zadeh A, Matuskey D. Relationship between neuroimaging and cognition in frontotemporal dementia: An FDG‐PET and structural MRI study. Journal Of Neuroimaging 2024, 34: 627-634. PMID: 38676301, PMCID: PMC11511789, DOI: 10.1111/jon.13206.Peer-Reviewed Original ResearchAltmetricConceptsMoCA scoresFDG-PETAssociation of cognitionStandardized uptake value ratioMontreal Cognitive AssessmentSignificant positive associationFrontotemporal dementiaPrimary outcome measurePosterior cingulate cortexDecline of cognitive functionYears of ageGM volumeFrontal cortexOutcome measuresCognitive dysfunctionGray matterCognitive AssessmentMoCAAssociated with cognitive dysfunctionFluorodeoxyglucose (FDG)-PETPositive associationMagnetic resonance imagingPartial volume correctionCognitive functionDementiaThe Relationship of Cerebrospinal Fluid Biomarkers and Cognitive Performance in Frontotemporal Dementia.
Cayir S, Sadabad FE, Mecca A, Matuskey D, Zadeh AF. The Relationship of Cerebrospinal Fluid Biomarkers and Cognitive Performance in Frontotemporal Dementia. Res Sq 2024 PMID: 38410483, DOI: 10.21203/rs.3.rs-3945509/v2.Peer-Reviewed Original Research In Press
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Yale School of Medicine
801 Howard Ave
New Haven, Connecticut 06510
United States