2004
Expression Profiling Reveals Novel Pathways in the Transformation of Melanocytes to Melanomas
Hoek K, Rimm DL, Williams KR, Zhao H, Ariyan S, Lin A, Kluger HM, Berger AJ, Cheng E, Trombetta ES, Wu T, Niinobe M, Yoshikawa K, Hannigan GE, Halaban R. Expression Profiling Reveals Novel Pathways in the Transformation of Melanocytes to Melanomas. Cancer Research 2004, 64: 5270-5282. PMID: 15289333, DOI: 10.1158/0008-5472.can-04-0731.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkers, TumorCell Transformation, NeoplasticCohort StudiesDown-RegulationGene Expression ProfilingGene Expression Regulation, NeoplasticHumansLymphatic MetastasisMelanocytesMelanomaMiceNuclear ProteinsOligonucleotide Array Sequence AnalysisPrognosisSignal TransductionSkin NeoplasmsSurvival RateTranscription FactorsTransfectionTwist-Related Protein 1Ubiquitin ThiolesteraseConceptsGlobal differential gene expressionMembrane trafficking eventsNovel pathwayNormal melanocytesHelix protein TwistAdditional transcriptional regulatorsDifferential gene expressionMelanoma cellsTransformation of melanocytesCpG promoter methylationNormal human melanocytesTrafficking eventsTranscriptional regulatorsEmbryonic developmentGrowth suppressorChromosomal regionsExpression profilingGene expressionNotch pathwayOligonucleotide microarraysMelanoma tissue microarrayDifferential expressionGenesHuman melanocytesGrowth advantage
1998
Melanomas, from the cell cycle point of view (Review).
Halaban R, Miglarese M, Smicun Y, Puig S. Melanomas, from the cell cycle point of view (Review). International Journal Of Molecular Medicine 1998, 1: 419-25. PMID: 9852245, DOI: 10.3892/ijmm.1.2.419.Peer-Reviewed Original ResearchConceptsRetinoblastoma tumor suppressor proteinTransformation of melanocytesTumor suppressor proteinCyclin-dependent kinase inhibitorCell cycle progressionDependent kinase inhibitorCell cycle pointMetastatic melanoma cellsCDK regulatorsCDK activitySuppressor proteinTarget genesGenetic lossCycle progressionRb phosphorylationUnrestricted proliferationAutocrine growth factorReduced expressionKinase inhibitorsMelanoma cellsGrowth factorAberrant productionExpressionE2FCKI
1989
Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment.
Dotto G, Moellmann G, Ghosh S, Edwards M, Halaban R. Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment. Journal Of Cell Biology 1989, 109: 3115-3128. PMID: 2556408, PMCID: PMC2115972, DOI: 10.1083/jcb.109.6.3115.Peer-Reviewed Original ResearchConceptsBasic fibroblast growth factorMurine melanocytesTransformation of melanocytesNormal murine melanocytesMetastatic melanoma cellsSynthesis of melaninMelanotic phenotypeConstitutive expressionFibroblast growth factorOncogene MYCRespective transformantsTransformantsFactor cDNAFormation of tumorsReconstitution experimentsDifferentiated functionsRecombinant retrovirusExogenous basic fibroblast growth factorOncogeneAutonomous growthExpression of bFGFCDNAConstitutive productionNude miceMelanocytes
1986
Human Melanocytes Cultured from Nevi and Melanomas
Halaban R, Ghosh S, Duray P, Kirkwood J, Lerner A. Human Melanocytes Cultured from Nevi and Melanomas. Journal Of Investigative Dermatology 1986, 87: 95-101. PMID: 2425008, DOI: 10.1111/1523-1747.ep12523594.Peer-Reviewed Original ResearchConceptsPresence of mitogensHuman melanocytesNeonatal melanocytesRate of proliferationPrimary melanomaCongenital neviMalignant transformationTransformation of melanocytesCholera toxinIsobutylmethyl xanthineHuman placentaGrowth factorProliferative rateMelanomaNewborn foreskinUnidentified factorsCell linesMelanocytesMitogenNeviHuman neonatal melanocytesPopulation doublingsMonthsLate eventProliferation