2000
Pharmacologic Treatment of Tic Disorders
Scahill L, Chappell P, King R, Leckman J. Pharmacologic Treatment of Tic Disorders. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 99-117. PMID: 10674192, DOI: 10.1016/s1056-4993(18)30137-8.Peer-Reviewed Original ResearchConceptsTic disordersTreatment of ADHDAtypical neurolepticsLong-term side effectsNewer atypical neurolepticsFirst-line treatmentTreatment of ticsBotulinum toxin injectionMore studiesUse of stimulantsNonstimulant medicationsToxin injectionPharmacologic treatmentPsychiatric comorbidityStandard treatmentTraditional neurolepticsTarget symptomsSide effectsStimulant medicationMedicationsNeurolepticsAdverse effectsComorbid ADHDDisordersTreatment planning
1995
Risperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report
LOMBROSO P, SCAHILL L, KING R, LYNCH K, CHAPPELL P, PETERSON B, McDOUGLE C, LECKMAN J. Risperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1147-1152. PMID: 7559308, DOI: 10.1097/00004583-199509000-00011.Peer-Reviewed Original ResearchConceptsChronic tic disorderTic disordersObsessive-compulsive disorderChronic motor tic disorderYale Global Tic Severity ScaleDopamine-blocking propertiesOpen-label trialFrequent side effectsEfficacy of risperidoneMotor tic disorderShort-term safetyTic Severity ScaleComorbid obsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleClinical responseRisperidone treatmentMean ageTic scoreSeverity ScaleSide effectsTourette syndromeComorbid diagnosesTic frequencyWeight gain
1994
Fluvoxamine Open-Label Treatment of Adolescent Inpatients with Obsessive-Compulsive Disorder or Depression
APTER A, RATZONI G, KING R, WEIZMAN A, IANCU I, BINDER M, RIDDLE M. Fluvoxamine Open-Label Treatment of Adolescent Inpatients with Obsessive-Compulsive Disorder or Depression. Journal Of The American Academy Of Child & Adolescent Psychiatry 1994, 33: 342-348. PMID: 8169178, DOI: 10.1097/00004583-199403000-00007.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMajor depressive disorderYale-Brown Obsessive Compulsive ScaleOvert Aggression ScaleBeck Depression InventorySide effectsSuicide Potential ScaleSpecific serotonin uptake inhibitorAdolescent inpatientsEfficacy of fluvoxamineOpen-label trialOpen-label treatmentCommon side effectsSerotonin uptake inhibitorSerious side effectsShort-term treatmentY-BOCS scoresObsessive Compulsive ScaleDaily dosesTarget symptomsDepressive disorderDemonstrated efficacyInvestigational basisUptake inhibitorFluvoxamine
1992
Double-Blind, Crossover Trial of Fluoxetine and Placebo in Children and Adolescents with Obsessive-Compulsive Disorder
RIDDLE M, SCAHILL L, KING R, HARDIN M, ANDERSON G, ORT S, SMITH J, LECKMAN J, COHEN D. Double-Blind, Crossover Trial of Fluoxetine and Placebo in Children and Adolescents with Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 1992, 31: 1062-1069. PMID: 1429406, DOI: 10.1097/00004583-199211000-00011.Peer-Reviewed Original ResearchConceptsChildren's Yale-Brown Obsessive Compulsive ScaleObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleEffective short-term treatmentSafety of fluoxetineFixed-dose trialCommon drug side effectsCY-BOCS total scoreMajor depressive disorderShort-term treatmentDrug side effectsMagnitude of improvementObsessive Compulsive ScaleFluoxetine groupPlacebo groupFluoxetine treatmentCrossover trialClinical trialsDepressive disorderObsessive-compulsive symptom severitySide effectsFluoxetineSymptom severityTotal scoreCompulsive Scale
1990
Behavioral Side Effects of Fluoxetine in Children and Adolescents
RIDDLE M, KING R, HARDIN M, SCAHILL L, ORT S, CHAPPELL P, RASMUSSON A, LECKMAN J. Behavioral Side Effects of Fluoxetine in Children and Adolescents. Journal Of Child And Adolescent Psychopharmacology 1990, 1: 193-198. DOI: 10.1089/cap.1990.1.193.Peer-Reviewed Original ResearchBehavioral side effectsSide effectsObsessive-compulsive symptomsExacerbation of symptomsCompulsive symptomsCommon psychopathological symptomsNeurological statusDosage reductionComplete resolutionSleep disturbancesMotor restlessnessLow dosesUnwanted symptomsFluoxetineSymptomsSubjective sensationPsychopathological symptomsLow dosageAge 8ChildrenDosesRestlessness