1995
Decreased cerebral blood flow during acute hyperglycemia
Duckrow R. Decreased cerebral blood flow during acute hyperglycemia. Brain Research 1995, 703: 145-150. PMID: 8719626, DOI: 10.1016/0006-8993(95)01077-7.Peer-Reviewed Original ResearchConceptsAcute hyperglycemiaCerebral blood flow decreasesPlasma osmolalityBlood flow decreasePentobarbital-anesthetized ratsCerebral blood flowLaser Doppler flowmetryAcute elevationMannitol injectionCBF increaseIntraperitoneal injectionTransient depressionBlood flowBaseline levelsHyperglycemiaElectroencephalographic activityTransient increaseFlow decreasesCBFOsmolalityBrief transient increaseInjectionContinuous measureFlowmetryRats
1993
A brief hypoperfusion precedes spreading depression if nitric oxide synthesis is inhibited
Duckrow R. A brief hypoperfusion precedes spreading depression if nitric oxide synthesis is inhibited. Brain Research 1993, 618: 190-195. PMID: 8374751, DOI: 10.1016/0006-8993(93)91265-t.Peer-Reviewed Original Research
1992
Cortical hypoperfusion following spreading depression is not altered by tirilazad mesylate (U-74006F) in awake rats
Duckrow R, Beard D. Cortical hypoperfusion following spreading depression is not altered by tirilazad mesylate (U-74006F) in awake rats. Brain Research 1992, 572: 296-299. PMID: 1611527, DOI: 10.1016/0006-8993(92)90488-u.Peer-Reviewed Original Research
1991
Regional Cerebral Blood Flow during Spreading Cortical Depression in Conscious Rats
Duckrow R. Regional Cerebral Blood Flow during Spreading Cortical Depression in Conscious Rats. Cerebrovascular And Brain Metabolism Reviews 1991, 11: 150-154. PMID: 1983999, DOI: 10.1038/jcbfm.1991.18.Peer-Reviewed Original ResearchConceptsConscious ratsCortical depressionCBF changesRegional CBFRegional cerebral blood flowCerebral cortex contralateralConscious restrained ratsCerebral blood flowEarly transient increaseDirect current stimulationLateral frontal cortexRelative hyperperfusionCortex contralateralVascular responsesFrontal cortexRestrained ratsBlood flowCerebral hemispheresRatsCurrent stimulationTransient increaseBrain dissectionEEG activityCBFHyperperfusion
1990
Effect of hemodilution on regional cerebral blood flow during chronic hyperglycemia in rats.
Duckrow RB. Effect of hemodilution on regional cerebral blood flow during chronic hyperglycemia in rats. Stroke 1990, 21: 1072-1076. PMID: 2368109, DOI: 10.1161/01.str.21.7.1072.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowCerebral blood flowReduced regional cerebral blood flowAverage cerebral blood flowChronic hyperglycemiaBlood flowElevated hematocritBrain regionsCerebral blood flow decreasesRegional cerebral blood flow decreasesBlood flow decreaseEffect of hemodilutionIsovolemic hemodilutionRestrained ratsHyperglycemiaHemodilutionHematocritRatsFlow decreasesStreptozotocinDissection
1988
Regional cerebral blood flow and glucose utilization during hyperinsulinemia
Duckrow R. Regional cerebral blood flow and glucose utilization during hyperinsulinemia. Brain Research 1988, 462: 363-366. PMID: 3191397, DOI: 10.1016/0006-8993(88)90566-5.Peer-Reviewed Original ResearchGlucose transfer into rat brain during acute and chronic hyperglycemia
Duckrow R. Glucose transfer into rat brain during acute and chronic hyperglycemia. Metabolic Brain Disease 1988, 3: 201-209. PMID: 3221811, DOI: 10.1007/bf00999236.Peer-Reviewed Original ResearchConceptsPermeability-surface area productChronic hyperglycemiaBrain capillary permeability-surface area productBlood-brain barrierBrain glucose contentAcute hyperglycemiaGlucose transportIntraperitoneal injectionHyperglycemic ratsRestrained ratsRat brainHyperglycemiaCapillary permeability-surface area productGlucose transferRatsFacilitated glucose transportArea productBrain
1987
Regional Cerebral Glucose Utilization During Hyperglycemia
Duckrow R, Bryan R. Regional Cerebral Glucose Utilization During Hyperglycemia. Journal Of Neurochemistry 1987, 48: 989-993. PMID: 2949062, DOI: 10.1111/j.1471-4159.1987.tb05614.x.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowRegional cerebral glucose utilizationCerebral glucose utilizationChronic hyperglycemiaAcute hyperglycemiaGlucose utilizationCerebral blood flowCerebral metabolic rateMetabolic rateIntraperitoneal injectionRestrained ratsRCMRglBlood flowHyperglycemiaKetone bodiesOxidative metabolismBrainPrevious dataStreptozotocinDecreaseRatsWeeksRegional cerebral blood flow decreases during chronic and acute hyperglycemia.
Duckrow RB, Beard DC, Brennan RW. Regional cerebral blood flow decreases during chronic and acute hyperglycemia. Stroke 1987, 18: 52-58. PMID: 2949400, DOI: 10.1161/01.str.18.1.52.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowChronic hyperglycemiaAcute hyperglycemiaPlasma glucoseAcute elevationCerebral blood flow decreasesRegional cerebral blood flow decreasesIschemic cell damageBlood flow decreasePresence of hyperglycemiaCerebral blood flowMicrons/Blood flow changesAwake restrained ratsFlow reductionBrain ischemiaNeuronal damageStroke patientsCardiac arrestBlood glucosePeritoneal spaceRestrained ratsBlood flowForebrain regionsHyperglycemia
1985
Regional cerebral blood flow decreases during hyperglycemia
Duckrow R, Beard D, Brennan R. Regional cerebral blood flow decreases during hyperglycemia. Annals Of Neurology 1985, 17: 267-272. PMID: 3922283, DOI: 10.1002/ana.410170308.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowBrain ischemiaCerebral blood flow decreasesRegional cerebral blood flow decreasesStroke-related morbidityBlood flow decreasePlasma osmolalityPresence of hyperglycemiaCerebral blood flowEffects of hyperglycemiaAcute hyperglycemiaPlasma glucoseIntraperitoneal injectionNormal salineAwake ratsRestrained ratsBlood flowQuantitative autoradiographyHyperglycemiaExperimental animalsFlow limitationIschemiaRatsOsmolalityGlucose
1982
Sensitive and inexpensive dual-wavelength reflection spectrophotometry using interference filters
Duckrow RB, LaManna JC, Rosenthal M. Sensitive and inexpensive dual-wavelength reflection spectrophotometry using interference filters. Analytical Biochemistry 1982, 125: 13-23. PMID: 6293337, DOI: 10.1016/0003-2697(82)90377-3.Peer-Reviewed Original Research
1981
Disparate recovery of resting and stimulated oxidative metabolism following transient ischemia.
Duckrow RB, LaManna JS, Rosenthal M. Disparate recovery of resting and stimulated oxidative metabolism following transient ischemia. Stroke 1981, 12: 677-686. PMID: 6272454, DOI: 10.1161/01.str.12.5.677.Peer-Reviewed Original ResearchConceptsMinutes of reperfusionTransient ischemiaMetabolic dysfunctionElectrocortical activityHours of reperfusionTransient cerebral ischemiaCarotid artery ligationOxidative responseLocal blood volumeOxidative metabolic functionCerebral ischemiaIschemic intervalArtery ligationRat brainBlood volumeElectrical stimulationCerebral surfaceReperfusionIschemiaOxidative metabolismMitochondrial redox stateDysfunctionEventual recoveryMetabolic functionsDisparate recoveryCerebral compensation for chronic noradrenergic denervation induced by locus ceruleus lesion: recovery of receptor binding, isoproterenol- induced adenylate cyclase activity, and oxidative metabolism
Harik SI, Duckrow RB, LaManna JC, Rosenthal M, Sharma VK, Banerjee SP. Cerebral compensation for chronic noradrenergic denervation induced by locus ceruleus lesion: recovery of receptor binding, isoproterenol- induced adenylate cyclase activity, and oxidative metabolism. Journal Of Neuroscience 1981, 1: 641-649. PMID: 7346572, PMCID: PMC6564177, DOI: 10.1523/jneurosci.01-06-00641.1981.Peer-Reviewed Original ResearchConceptsLocus ceruleus lesionNoradrenergic denervationCerebral cortexReceptor bindingNoradrenergic receptor bindingOxidative metabolismRat cerebral cortexDirect cortical stimulationVivo oxidative metabolismBlood volume shiftsCyclic AMP generationAdenylate cyclase activityCerebral compensationNoradrenaline depletionLocus ceruleusUnilateral injectionCortical stimulationCerebral noradrenalineLong-term effectsAMP generationMonophosphate generationLesionsDenervationCyclase activityWeeks
1977
The effect of diphenylhydantoin on self-mutilation in rats produced by unilateral multiple dorsal rhizotomy
Duckrow RB, Taub A. The effect of diphenylhydantoin on self-mutilation in rats produced by unilateral multiple dorsal rhizotomy. Experimental Neurology 1977, 54: 33-41. PMID: 556697, DOI: 10.1016/0014-4886(77)90232-1.Peer-Reviewed Original ResearchConceptsDorsal rhizotomyCentral dysfunctionMultiple dorsal rhizotomiesPossible etiologic roleEffect of diphenylhydantoinSpinal cord histologyFemale albino ratsSpinal pathwaysAfferent pathwaysEtiologic roleCord histologyAlbino ratsRhizotomyDiphenylhydantoinRatsSelf-MutilationDysfunctionDrug vehicleAnimalsDaysVideotape techniqueAnesthesiaHistologyIncidencePathway