Genetic Differentiation of Appendiceal Tumor Malignancy
Modlin IM, Kidd M, Latich I, Zikusoka MN, Eick GN, Mane SM, Camp RL. Genetic Differentiation of Appendiceal Tumor Malignancy. Annals Of Surgery 2006, 244: 52-60. PMID: 16794389, PMCID: PMC1570599, DOI: 10.1097/01.sla.0000217617.06782.d5.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentAdultAgedAged, 80 and overAntigens, NeoplasmApoptosis Regulatory ProteinsAppendiceal NeoplasmsAppendicitisBiomarkers, TumorCarcinoid TumorCell Cycle ProteinsChildChromogranin AChromograninsDiagnosis, DifferentialFemaleGene ExpressionGenetic MarkersHistone DeacetylasesHumansImmunohistochemistryMaleMiddle AgedNLR ProteinsNuclear ProteinsNucleosome Assembly Protein 1Repressor ProteinsReverse Transcriptase Polymerase Chain ReactionTrans-ActivatorsConceptsAppropriate surgical managementAppendiceal carcinoidsAppendiceal tumorsSurgical managementMAGE-D2Malignant appendiceal tumorsAppendiceal adenocarcinoidAdenocarcinoid tumorCarcinoid tumorsHistologic evidenceIncidental lesionsColorectal cancerPathologic criteriaQ-RT-PCRAppendiceal tissueGene expressionNormal mucosaTumor potentialCarcinoidsTumor behaviorAppendicitisAdenocarcinoidMorphologic assessmentTumor typesTumor malignancyQ RT-PCR Detection of Chromogranin A
Kidd M, Modlin IM, Mane SM, Camp RL, Shapiro MD. Q RT-PCR Detection of Chromogranin A. Annals Of Surgery 2006, 243: 273-280. PMID: 16432362, PMCID: PMC1448909, DOI: 10.1097/01.sla.0000197734.28551.0f.Peer-Reviewed Original ResearchConceptsGI carcinoidsGI adenocarcinomasQ-RT-PCRNormal mucosaLymph node metastasisNormal lymph nodesCgA gene expressionCgA protein levelsProtein expression levelsAppendiceal tumorsNormal LNsLiver metastasesLN metastasisLymph nodesNode metastasisAppendiceal carcinoidsNonmetastatic lesionsEpithelial tumorsCgA levelsTissue microarrayTherapeutic strategiesCarcinoidsNE cellsImmunohistochemical measurementsRT-PCR detectionThe Role of Genetic Markers— NAP1L1, MAGE-D2, and MTA1—in Defining Small-Intestinal Carcinoid Neoplasia
Kidd M, Modlin IM, Mane SM, Camp RL, Eick G, Latich I. The Role of Genetic Markers— NAP1L1, MAGE-D2, and MTA1—in Defining Small-Intestinal Carcinoid Neoplasia. Annals Of Surgical Oncology 2006, 13: 253-262. PMID: 16424981, DOI: 10.1245/aso.2006.12.011.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdultAgedAntigens, NeoplasmBiomarkers, TumorCarcinoid TumorCell Cycle ProteinsFemaleGenetic MarkersHistone DeacetylasesHumansIntestinal NeoplasmsIntestine, SmallMaleMiddle AgedNuclear ProteinsNucleosome Assembly Protein 1Repressor ProteinsReverse Transcriptase Polymerase Chain ReactionTissue Array AnalysisTrans-ActivatorsConceptsSmall intestinal carcinoidsQuantitative reverse transcriptase-polymerase chain reactionColorectal carcinomaMAGE-D2Primary tumorLymph node metastasisImmunohistochemical expression levelsReverse transcriptase-polymerase chain reactionNonmetastatic primary tumorsTranscriptase-polymerase chain reactionHealthy tissueGastrointestinal carcinoidsLN metastasisNode metastasisIntestinal carcinoidsPrognostic utilityHealthy mucosaMalignant potentialProstate carcinomaTissue microarrayImmunohistochemical methodsCarcinomaImmunohistochemical approachMetastasisCarcinoids