pH Modulation of Voltage-Gated Sodium Channels
Peters CH, Ghovanloo MR, Gershome C, Ruben PC. pH Modulation of Voltage-Gated Sodium Channels. Handbook Of Experimental Pharmacology 2018, 246: 147-160. PMID: 29460150, DOI: 10.1007/164_2018_99.Peer-Reviewed Original ResearchConceptsElectrical diseaseSodium channelsChannel gatingDisease-causing mutantsSodium channel poreTransient sodium currentModulation of VoltageIschemic strokeNon-inactivating channelsSkeletal muscle sodium channelsAcute symptomsCocaine ingestionCardiac ischemiaSodium channel mutationsMuscle sodium channelsSodium currentIsoform specificitySodium channel gatingTissue-level effectsPathophysiological conditionsChannel mutationsSkeletal muscleDiseaseCardiac tissueChannel poreEffects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3
Ghovanloo MR, Peters CH, Ruben PC. Effects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3. Channels 2018, 12: 367-377. PMID: 30362397, PMCID: PMC6284583, DOI: 10.1080/19336950.2018.1539611.Peer-Reviewed Original ResearchConceptsSodium channel subtypesVoltage-gated sodium channelsChannel subtypesNeuronal voltage-gated sodium channelsSodium channelsEffect of acidosisSteady-state fast inactivationPH-sensitive channelsNeonatal neuronsFast inactivationAdult neuronsInhibitory neuronsPathophysiological manifestationsNav1.3Nav1.1Membrane excitabilityExtracellular acidosisNeuronsSubtypesAcidosisModerate reductionExtracellular pHTissue-specific mannerKey contributorExcitability