2022
Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol
Ghovanloo M, Dib-Hajj S, Goodchild S, Ruben P, Waxman S. Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol. Frontiers In Physiology 2022, 13: 1066455. PMID: 36439273, PMCID: PMC9691960, DOI: 10.3389/fphys.2022.1066455.Peer-Reviewed Original Research
2021
Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications
Ghovanloo MR, Ruben PC. Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications. The Neuroscientist 2021, 28: 318-334. PMID: 34027742, PMCID: PMC9344566, DOI: 10.1177/10738584211017009.Peer-Reviewed Original ResearchConceptsClinical implicationsNav channelsPotential therapeutic meansInteractions of cannabidiolVoltage-gated sodiumSodium channel pharmacologyClinical syndromePreclinical studiesCBD useNeurological conditionsCBD interactionsChannel pharmacologyTherapeutic meansAction potentialsMuscular problemsPathophysiological conditionsCannabidiolChannel functionExcitable tissuesViable compoundCannabis plantTissueDifferent tissuesHyperexcitabilitySyndrome
2018
Inhibitory effects of cannabidiol on voltage-dependent sodium currents
Ghovanloo MR, Shuart NG, Mezeyova J, Dean RA, Ruben PC, Goodchild SJ. Inhibitory effects of cannabidiol on voltage-dependent sodium currents. Journal Of Biological Chemistry 2018, 293: 16546-16558. PMID: 30219789, PMCID: PMC6204917, DOI: 10.1074/jbc.ra118.004929.Peer-Reviewed Original ResearchConceptsAnticonvulsant effectsVoltage-dependent sodium currentsPotassium channelsSafety of cannabidiolNav channelsCentral nervous system targetsEffects of cannabidiolNervous system targetsVoltage-dependent currentsVoltage-gated potassium channelsVoltage-clamp electrophysiologyAntiepileptic effectClinical efficacyCase reportAlters membrane fluidityIPSC-neuronsTherapeutic mechanismSodium currentHEK-293 cellsReceptor pathwayΔ9-tetrahydrocannabinolInhibitory effectCannabidiolChannel excitabilitySodium channels