2022
Transient receptor potential melastatin 7 and their modulators
Cheng X, Li S, Chen Y, Zhao Y, Hu W, Lu C, Zhou R. Transient receptor potential melastatin 7 and their modulators. European Journal Of Pharmacology 2022, 931: 175180. PMID: 35940237, DOI: 10.1016/j.ejphar.2022.175180.Peer-Reviewed Original ResearchConceptsUnique domain structureCation channelsRegulation of TRPM7Transient receptor potential melastatin 7Molecular signaling pathwaysProtein kinaseFunction of TRPM7Regulatory mechanismsPhysiological processesInternal regulatory mechanismsSignaling pathwaysExogenous regulationNonselective cation channelsCell membraneTRPM7Development of tumorsCell proliferationTRPM7 activityPhenotypic transformationRegulationPharmacological compoundsImportant targetIntracellular MgTRPM7 expressionTissue fibrosisTRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis
Zhou R, Chen Y, Li S, Wei X, Hu W, Tang S, Ding J, Fu W, Zhang H, Chen F, Hao W, Lin Y, Zhu R, Wang K, Dong L, Zhao Y, Feng X, Chen F, Ding C, Hu W. TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis. Redox Biology 2022, 55: 102411. PMID: 35917680, PMCID: PMC9344030, DOI: 10.1016/j.redox.2022.102411.Peer-Reviewed Original ResearchArticular cartilage destructionRheumatoid arthritisCartilage destructionChannel inhibitionPharmacological inhibitionTreatment of RAHuman RA patientsAdjuvant arthritis ratsExpression of TRPM7Primary rat articular chondrocytesArticular cartilage damageArticular chondrocytesRat articular chondrocytesRA patientsArthritis ratsTRPM7 channel activityAA ratsCartilage damageIntracellular CaVirus 9Human chondrocytesPromising targetFerroptosis inducersFerroptosisTRPM7
2021
Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases
Liang H, Chen Y, Wei X, Ma G, Ding J, Lu C, Zhou R, Hu W. Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases. Immunology 2021, 165: 3-21. PMID: 34558663, DOI: 10.1111/imm.13420.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmune DiseasesAutoimmunityBiomarkersDisease SusceptibilityDrug DevelopmentGene Expression RegulationHumansImmune SystemImmunomodulationIon Channel GatingOrgan SpecificityProtein Kinase InhibitorsProtein Serine-Threonine KinasesSignal TransductionStructure-Activity RelationshipTRPM Cation ChannelsConceptsAutoimmune diseasesRole of TRPM7New treatment targetsPotential therapeutic targetReceptor ion channelsImmune toleranceRheumatoid arthritisMultiple sclerosisSystemic disordersBody of evidenceImmune cellsCytokine secretionImmunoreactive substancesFunctional damageImmunomodulatory functionsTherapeutic targetTreatment targetsDiseaseEffective interventionsPharmacological propertiesOne-tissueTRPM7Physiologic conditionsInappropriate responsesCell migration