NS8593 inhibits sodium nitroprusside-induced chondrocyte apoptosis by mediating the STING signaling pathway
Zhu R, Hao W, Li S, Chen Y, Zhou F, Zhou R, Hu W. NS8593 inhibits sodium nitroprusside-induced chondrocyte apoptosis by mediating the STING signaling pathway. Heliyon 2024, 10: e31375. PMID: 38831839, PMCID: PMC11145487, DOI: 10.1016/j.heliyon.2024.e31375.Peer-Reviewed Original ResearchTransient receptor potential cation channel subfamily M member 7STING signaling pathwayCyclic GMP-AMP synthase (cGAS)-stimulatorSNP-induced decreaseAtrial fibrillation therapyPhosphorylation levelsSignaling pathwayApoptosis in vitroCell viabilityNS8593Atrial fibrillationDose-dependentlyImprove atrial fibrillationInterferon genesSNP-induced chondrocyte apoptosisArticular cartilage damageApoptosisChondrocyte apoptosisFeatures of osteoarthritisChondrocyte apoptosis in vitroArticular cartilage destructionCartilage destructionCartilage damageStingsTreatment