2018
B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4γ13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters
Johnson RM, Yu H, Strank N, Karunakaran K, Zhu Y, Brunham RC. B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4γ13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters. Infection And Immunity 2018, 86: 10.1128/iai.00614-17. PMID: 29158429, PMCID: PMC5778355, DOI: 10.1128/iai.00614-17.Peer-Reviewed Original ResearchConceptsMemory lymphocyte clustersPeripheral blood mononuclear cellsT cell subsetsAntigen-presenting cellsT cell clonesB cell populationsT cellsLymphocyte clustersCell subsetsB cellsTissue-resident memory T cellsCD4 T-cell clonesCD4 T cell subsetsHuman peripheral blood mononuclear cellsCell clonesMemory T cellsBlood mononuclear cellsIL-13 responsesImmune B cellsB cell presentationCell populationsAdoptive transferImmune miceIntracellular bacterial pathogenChlamydia antigen
2015
Modeling the transcriptome of genital tract epithelial cells and macrophages in healthy mucosa versus mucosa inflamed by Chlamydia muridarum infection
Johnson RM, Kerr MS. Modeling the transcriptome of genital tract epithelial cells and macrophages in healthy mucosa versus mucosa inflamed by Chlamydia muridarum infection. Pathogens And Disease 2015, 73: ftv100. PMID: 26519447, PMCID: PMC4732027, DOI: 10.1093/femspd/ftv100.Peer-Reviewed Original ResearchConceptsEpithelial cellsLineage-specific differencesGene expression microarray technologyExpression microarray technologyBone marrow-derived macrophagesMarrow-derived macrophagesAdaptive immunityReproductive tract epitheliumCell line responsePrincipal cell typesMicroarray technologyIntracellular bacteriaChlamydia-specific T cellsGenital tract epithelial cellsCell typesBacterial replicationChlamydia muridarum infectionMHC class II moleculesEpithelial requirementTract epithelial cellsClass II moleculesInnate defenseHost defenseCoinhibitory ligandsInflamed/