2020
Comparison of Chlamydia outer membrane complex to recombinant outer membrane proteins as vaccine
Yu H, Karunakaran KP, Jiang X, Chan Q, Rose C, Foster LJ, Johnson RM, Brunham RC. Comparison of Chlamydia outer membrane complex to recombinant outer membrane proteins as vaccine. Vaccine 2020, 38: 3280-3291. PMID: 32151463, DOI: 10.1016/j.vaccine.2020.02.059.Peer-Reviewed Original ResearchConceptsChlamydial outer membrane complexRecombinant outer membrane proteinsImmune responseT-cell vaccine candidatesElementary bodiesReactive immune responsesC. muridarum elementary bodiesGenital infectionMajor outer membrane proteinTubal pathologyC. trachomatis serovarsVaccine efficacyOuter membrane proteinsSuperior efficacyVaccine candidatesBroad immunogenicityC. trachomatisVaccineAntibodiesSuperior protectionMultiple outer membrane proteinsOuter membrane complexPathologyEfficacyPolymorphic membrane proteins
2016
Tissue-Resident T Cells as the Central Paradigm of Chlamydia Immunity
Johnson RM, Brunham RC. Tissue-Resident T Cells as the Central Paradigm of Chlamydia Immunity. Infection And Immunity 2016, 84: 868-873. PMID: 26787715, PMCID: PMC4807466, DOI: 10.1128/iai.01378-15.Peer-Reviewed Original ResearchConceptsT cellsTissue-resident memory T cellsTissue-resident T cellsMemory T cellsChlamydia immunityCytokine polarizationTrachoma vaccineChlamydia vaccineVaccine efficacyPathogenesis dataPathogenesis investigationPreclinical pipelineImmunity studiesHuman subjectsVaccineImmune networkCellsMiceImmunity