2022
Combining Cellular Immunology With RNAseq to Identify Novel Chlamydia T-Cell Subset Signatures
Johnson RM, Asashima H, Mohanty S, Shaw AC. Combining Cellular Immunology With RNAseq to Identify Novel Chlamydia T-Cell Subset Signatures. The Journal Of Infectious Diseases 2022, 225: 2033-2042. PMID: 35172331, PMCID: PMC9159333, DOI: 10.1093/infdis/jiac051.Peer-Reviewed Original ResearchConceptsProtective T cell clonesAntibacterial effector mechanismsT cells residentB cell helpT cell clonesCytokine polarizationImmune miceIL-10Protective immunityVaccine trialsIL-13Surrogate biomarkerEffector mechanismsGenital tractT cellsVaccine candidatesChlamydia trachomatisCells residentHelper functionCellular immunologyMouse studiesHuman investigationsReproductive tractGranzyme A.Investigational data
2016
Tissue-Resident T Cells as the Central Paradigm of Chlamydia Immunity
Johnson RM, Brunham RC. Tissue-Resident T Cells as the Central Paradigm of Chlamydia Immunity. Infection And Immunity 2016, 84: 868-873. PMID: 26787715, PMCID: PMC4807466, DOI: 10.1128/iai.01378-15.Peer-Reviewed Original ResearchConceptsT cellsTissue-resident memory T cellsTissue-resident T cellsMemory T cellsChlamydia immunityCytokine polarizationTrachoma vaccineChlamydia vaccineVaccine efficacyPathogenesis dataPathogenesis investigationPreclinical pipelineImmunity studiesHuman subjectsVaccineImmune networkCellsMiceImmunity