2019
Discordance in the Epithelial Cell-Dendritic Cell Major Histocompatibility Complex Class II Immunoproteome: Implications for Chlamydia Vaccine Development
Karunakaran KP, Yu H, Jiang X, Chan QWT, Foster LJ, Johnson RM, Brunham RC. Discordance in the Epithelial Cell-Dendritic Cell Major Histocompatibility Complex Class II Immunoproteome: Implications for Chlamydia Vaccine Development. The Journal Of Infectious Diseases 2019, 221: 841-850. PMID: 31599954, PMCID: PMC7457330, DOI: 10.1093/infdis/jiz522.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, BacterialBacterial VaccinesCD4-Positive T-LymphocytesCell LineChlamydia InfectionsChlamydia muridarumChlamydia trachomatisDendritic CellsEpithelial CellsEpitopes, T-LymphocyteFemaleHeLa CellsHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHost-Pathogen InteractionsHumansMiceMice, Inbred C57BLPeptidesConceptsCD4 T cellsDendritic cellsT cellsEpithelial cellsProtective immunityEffector phaseClass IChlamydia-specific CD4 T cellsPathogen-specific T cellsClass IIMajor histocompatibility complex (MHC) class II moleculesChlamydia vaccine developmentClearance of ChlamydiaClass II epitopesClass II moleculesMHC class IMucosal epithelial cellsInfected epithelial cellsImmune miceIntracellular bacterial pathogenChlamydia vaccineC trachomatisEpithelial cell linePresent epitopesChlamydia trachomatis
2016
Tissue-Resident T Cells as the Central Paradigm of Chlamydia Immunity
Johnson RM, Brunham RC. Tissue-Resident T Cells as the Central Paradigm of Chlamydia Immunity. Infection And Immunity 2016, 84: 868-873. PMID: 26787715, PMCID: PMC4807466, DOI: 10.1128/iai.01378-15.Peer-Reviewed Original ResearchConceptsT cellsTissue-resident memory T cellsTissue-resident T cellsMemory T cellsChlamydia immunityCytokine polarizationTrachoma vaccineChlamydia vaccineVaccine efficacyPathogenesis dataPathogenesis investigationPreclinical pipelineImmunity studiesHuman subjectsVaccineImmune networkCellsMiceImmunity