Featured Publications
Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience
Raredon MSB, Fisher C, Heerdt PM, Schonberger RB, Nargi A, Nivison S, Fajardo E, Deshpande R, Akhtar S, Greaney AM, Belter J, Raredon T, Zinter J, McKee A, Michalski M, Baevova P, Niklason LE. Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience. Anesthesia & Analgesia 2021, 134: 1094-1105. PMID: 34928890, DOI: 10.1213/ane.0000000000005825.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureClinical experienceIndividualized positive end-expiratory pressureIntensive care unitEnd-expiratory pressureCoronavirus disease 2019 (COVID-19) pandemicHealth care teamDisease 2019 pandemicVentilatory supportIll patientsCare unitCare teamVentilator sharingFuture clinical applicationsPatientsIndependent careVentilator capacityClinical applicationCOVID-19 pandemicVentilatorClinical environmentOutline recommendationsMass traumaPandemicHospitalIntubation and Ventilation amid the COVID-19 Outbreak
Meng L, Qiu H, Wan L, Ai Y, Xue Z, Guo Q, Deshpande R, Zhang L, Meng J, Tong C, Liu H, Xiong L. Intubation and Ventilation amid the COVID-19 Outbreak. Anesthesiology 2020, 132: 10.1097/aln.0000000000003296. PMID: 32195705, PMCID: PMC7155908, DOI: 10.1097/aln.0000000000003296.Peer-Reviewed Original ResearchConceptsHigh-flow oxygen therapyPositive airway pressure ventilationCOVID-19Prone position ventilationLung-protective ventilationRapid sequence inductionCOVID-19 outbreakIntubation strategyInvasive ventilationAdequate sedationDisease courseOxygen therapyIll patientsPressure ventilationSequence inductionRapid intubationIntubationVideo laryngoscopeEnhanced riskPatientsVentilation managementVentilationOxygen debtWuhanOutbreakLiver allocation and distribution
Deshpande R, Hirose R, Mulligan D. Liver allocation and distribution. Current Opinion In Organ Transplantation 2017, 22: 162-168. PMID: 28212159, DOI: 10.1097/mot.0000000000000397.Peer-Reviewed Original ResearchConceptsTransplant CommitteeTransplant centersEnd-Stage Liver Disease (MELD) pointsLiver allograft allocationDeceased donor liversLife-saving organsLiver allocation policyAllograft allocationLiver transplantLiver transplantationLiver diseaseDonor liversUnited NetworkDonor organsLiver distributionAdvanced stageLiver allocationOrgan distributionPatient accessTransplantationGeographic disparitiesLiverDisease pointHealthcare systemPatientsProcedural sedation in the ICU and emergency department
Chawla N, Boateng A, Deshpande R. Procedural sedation in the ICU and emergency department. Current Opinion In Anaesthesiology 2017, 30: 507-512. PMID: 28562388, DOI: 10.1097/aco.0000000000000487.Peer-Reviewed Original ResearchConceptsProcedural sedationEmergency departmentSedation ScaleOperating roomCommon adverse eventsOutcomes of patientsPhase 2 trialUse of capnographyBetter patient satisfactionAcute care settingMultidisciplinary team approachEmergency department settingAddition of ketamineProceduralist satisfactionSynergistic sedationPulmonary aspirationAdverse eventsPatient satisfactionDepartment settingPharmacologic agentsCare settingsSedationMultidisciplinary teamTeam approachCurrent safety guidelinesRegional anesthesia for transplantation surgery – A white paper part 1: Thoracic transplantation surgery
Ander M, Mugve N, Crouch C, Kassel C, Fukazawa K, Izaak R, Deshpande R, McLendon C, Huang J. Regional anesthesia for transplantation surgery – A white paper part 1: Thoracic transplantation surgery. Clinical Transplantation 2023, 37: e15043. PMID: 37306898, PMCID: PMC10834230, DOI: 10.1111/ctr.15043.Peer-Reviewed Original ResearchConceptsTransplantation surgeryRegional anesthesiaOpioid usePostoperative pain controlRegional anesthetic techniquesAnalgesic modalitiesAnalgesic effectivenessPain controlSurgery protocolNeuraxial blockPatient's hemodynamicsAnesthetic techniqueAbdominal transplantationTransplant anesthesiaSurgeryAnesthesiaSystemic reviewEnhanced recoveryTransplant techniquesPerioperative culturesLiterature searchFormal guidelinesAvailable literatureUltrasound machineTask ForceCritical care pharmacy practice advancement recommendations on direct patient care activities: An opinion of the American College of Clinical Pharmacy Critical Care Practice and Research Network
Critical care pharmacy practice advancement recommendations on direct patient care activities: An opinion of the American College of Clinical Pharmacy Critical Care Practice and Research Network Buckley, Mitchell S. a Send mail to Buckley M.S.; Acquisto, Nicole M. b; Adams, Christopher c; Brandt, Kimberly d; Ammar, Mahmoud A. e; Deshpande, Ranjit e; Bullard, Heather f; Santibañez, Melissa g; Fontaine, Gabriel V. h; Musselman, Megan i; Noble, Melissa j; Van Cleve, Jonathan kPeer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRelationship Between Glucose Time in Range in Diabetic and Non-Diabetic Patients and Mortality in Critically Ill Patients
Ammar MA, Ammar AA, Wee T, Deshpande R, Band M, Akhtar S. Relationship Between Glucose Time in Range in Diabetic and Non-Diabetic Patients and Mortality in Critically Ill Patients. Journal Of Intensive Care Medicine 2022, 37: 1625-1633. PMID: 35491687, DOI: 10.1177/08850666221098383.Peer-Reviewed Original ResearchConceptsNon-diabetic patientsBlood glucose rangeDiabetic patientsIll patientsGlucose rangeTIR 70Hospital mortalityMortality rateHospital mortality rateNon-diabetic cohortLower mortality rateAdult patientsCohort studyMortality benefitSingle centerGlucose timePercentage of timeHigh incidencePatientsMortalityDlLtDiabeticsICUHyperglycemiaTreatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study
Zhao X, Gao C, Dai F, Treggiari MM, Deshpande R, Meng L. Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study. Anesthesiology 2021, 135: 1076-1090. PMID: 34597362, DOI: 10.1097/aln.0000000000003999.Peer-Reviewed Original ResearchConceptsIll COVID-19 patientsCOVID-19 patientsPropensity score-matched analysisRetrospective cohort studyLower mortalityHospital mortalityCohort studyMultivariable analysisYale New Haven Health SystemIntensive care unit admissionOrgan support treatmentUse of apixabanCare unit admissionSevere COVID-19Intensive care unitCOVID-19 mortalityLower COVID-19 mortalityApixaban treatmentUnit admissionAspirin treatmentCare unitTreatment AssociatedCandidate treatmentSupport treatmentPatientsThe Development of a Comprehensive Multi-Institutional, Multi-Disciplinary Infrastructure for the Successful Implementation of a Robotic-Assisted Kidney Transplant (RAKT) Program
Haakinson D, Tzvetanov I, Turner A, Deshpande R, Formica R, Kulkarni S, Benedetti E, Mulligan D. The Development of a Comprehensive Multi-Institutional, Multi-Disciplinary Infrastructure for the Successful Implementation of a Robotic-Assisted Kidney Transplant (RAKT) Program. Journal Of The American College Of Surgeons 2020, 231: e224. DOI: 10.1016/j.jamcollsurg.2020.08.597.Peer-Reviewed Original ResearchLiver Transplantation in the Time of COVID19: Barriers and Ethical Considerations for Management and Next Steps
Jaffe A, Schilsky ML, Deshpande R, Batra R. Liver Transplantation in the Time of COVID19: Barriers and Ethical Considerations for Management and Next Steps. Hepatology Communications 2020, 4: 1242-1256. PMID: 32838103, PMCID: PMC7361607, DOI: 10.1002/hep4.1568.Peer-Reviewed Original ResearchEnd-stage liver diseaseLiver transplantLiver transplantationLiver diseaseVirus severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Syndrome coronavirus 2Critical care bedsLife-saving procedureHealth care systemCorona Virus DiseasePosttransplant recipientsCoronavirus 2Transplant programsTumor controlBlood productsCOVID19 infectionCare bedsPatientsStaff contactTransplantCare systemDiseaseCurrent approach to diagnosis and treatment of delirium after cardiac surgery
Evans AS, Weiner MM, Arora RC, Chung I, Deshpande R, Varghese R, Augoustides J, Ramakrishna H. Current approach to diagnosis and treatment of delirium after cardiac surgery. Annals Of Cardiac Anaesthesia 2016, 19: 328-337. PMID: 27052077, PMCID: PMC4900348, DOI: 10.4103/0971-9784.179634.Peer-Reviewed Original ResearchTraining the Anesthesiologist in Point-of-Care Ultrasound
Deshpande R, Montealegre-Gallegos M, Matyal R, Belani K, Chawla N. Training the Anesthesiologist in Point-of-Care Ultrasound. International Anesthesiology Clinics 2016, 54: 71-93. PMID: 26655510, DOI: 10.1097/aia.0000000000000088.Peer-Reviewed Original Research
2024
Identifying Variation in Intraoperative Management of Brain-Dead Organ Donors and Opportunities for Improvement: A Multicenter Perioperative Outcomes Group Analysis.
Lele A, Vail E, O'Reilly-Shah V, DeGraw X, Domino K, Walters A, Fong C, Gomez C, Naik B, Mori M, Schonberger R, Deshpande R, Souter M, Mathis M. Identifying Variation in Intraoperative Management of Brain-Dead Organ Donors and Opportunities for Improvement: A Multicenter Perioperative Outcomes Group Analysis. Anesthesia & Analgesia 2024 PMID: 39167559, DOI: 10.1213/ane.0000000000007001.Peer-Reviewed Original ResearchIntraclass correlation coefficientMulticenter Perioperative Outcomes GroupOrgan procurement organization regionBrain-dead organ donorsNon-Hispanic whitesPoisson regression analysisOrgan procurement organizationsIntraoperative eventsUS hospitalsYears of ageMedication useIncidence of hypotensionOrgan donorsManagement of brain-dead donorsPrimary outcomeManagement of brain-dead organ donorsMixed-effects Poisson regression analysisIntravenous heparinVasoactive medicationsBrain-dead donorsMulticenter cohortIntraoperative managementTransplant outcomesCase volumeMm HgRegional anesthesia for transplantation surgery ‐ A White Paper Part 2: Abdominal transplantation surgery
Ander M, Mugve N, Crouch C, Kassel C, Fukazawa K, Isaak R, Deshpande R, McLendon C, Huang J. Regional anesthesia for transplantation surgery ‐ A White Paper Part 2: Abdominal transplantation surgery. Clinical Transplantation 2024, 38: e15227. PMID: 38289879, DOI: 10.1111/ctr.15227.Peer-Reviewed Original ResearchConceptsSociety for the Advancement of Transplant AnesthesiaTransplant surgeryRegional anesthesiaPostoperative pain controlRegional anesthetic techniquesDevelopment of enhanced recoveryAvailability of ultrasound machinesAbdominal transplantationOpioid usePain controlAnalgesic effectNeuraxial blockPerioperative culturesPatient's hemodynamicsSurgeryUterus transplantationAnesthetic techniqueTransplantationReview available literatureAdvancement of Transplant AnesthesiaSystemic reviewTransplantation techniquesAnesthesiaLiterature searchUltrasound machine
2023
Perioperative Fluid Management and Volume Assessment
Elia J, Diwan M, Deshpande R, Brainard J, Karamchandani K. Perioperative Fluid Management and Volume Assessment. Anesthesiology Clinics 2023, 41: 191-209. PMID: 36871999, DOI: 10.1016/j.anclin.2022.10.010.Peer-Reviewed Original ResearchConceptsPerioperative fluid managementFluid managementFluid responsivenessFluid therapyAdequate organ perfusionIntraoperative fluid managementEvidence-based recommendationsCardiac preloadPerioperative careVolume statusVolume responsivenessStroke volumeOrgan perfusionBlood volumeVolume assessmentTherapyResponsivenessAccurate assessmentManagement
2022
Demonstration and Performance Evaluation of Two Novel Algorithms for Removing Artifacts From Automated Intraoperative Temperature Data Sets: Multicenter, Observational, Retrospective Study
Bardia A, Deshpande R, Michel G, Yanez D, Dai F, Pace NL, Schuster K, Mathis MR, Kheterpal S, Schonberger RB. Demonstration and Performance Evaluation of Two Novel Algorithms for Removing Artifacts From Automated Intraoperative Temperature Data Sets: Multicenter, Observational, Retrospective Study. JMIR Perioperative Medicine 2022, 5: e37174. PMID: 36197702, PMCID: PMC9591708, DOI: 10.2196/37174.Peer-Reviewed Original Research
2021
Reducing Opioid Dependence and Improving Patient Experience for Living Kidney Donors with Transversus Abdominis Plane Block
Do V, Cohen E, Haakinson D, Deshpande R, Batra R. Reducing Opioid Dependence and Improving Patient Experience for Living Kidney Donors with Transversus Abdominis Plane Block. Transplantology 2021, 2: 57-63. DOI: 10.3390/transplantology2010006.Peer-Reviewed Original ResearchLaparoscopic living-donor nephrectomyPatient-controlled analgesiaHydromorphone patient-controlled analgesiaPost-operative opioid useDays of dischargeTransversus abdominis planeTAP blockLiposomal bupivacaineOpioid useControl groupPain scoresPain managementOpioid dependenceKidney donorsStudy groupPost-operative pain scoresSingle-center retrospective studyTransversus abdominis plane blockComparable pain scoresLiving Donor NephrectomyPostoperative hospital lengthPreoperative TAP blockPatients 18 yearsPostoperative opioid usePerioperative pain managementThe Society for the Advancement of Transplant Anesthesia (SATA) enters a new partnership with Clinical Transplantation
Mandell MS, Sakai T, Wagener G, De Marchi L, Subramaniam K, JHuang J, Hendrickse A, Deshpande R, Ryan C, Pretto EA. The Society for the Advancement of Transplant Anesthesia (SATA) enters a new partnership with Clinical Transplantation. Clinical Transplantation 2021, 35: e14203. PMID: 33475197, DOI: 10.1111/ctr.14203.Peer-Reviewed Original Research
2020
Resource Utilization in Implementation of a Point of Care Ultrasound Curriculum for Resident Training in Anesthesiology.
Deshpande R, Karnik R, Baer C, Kurup V. Resource Utilization in Implementation of a Point of Care Ultrasound Curriculum for Resident Training in Anesthesiology. The Yale Journal Of Biology And Medicine 2020, 93: 423-427. PMID: 32874148, PMCID: PMC7448394.Peer-Reviewed Original ResearchAnesthesia at the Edge of Life
Deshpande R, Rosenbaum SH. Anesthesia at the Edge of Life. Anesthesiology Clinics 2020, 38: xv-xvi. PMID: 32008661, DOI: 10.1016/j.anclin.2019.12.001.Peer-Reviewed Original Research