2017
Elevated α-Hydroxybutyrate and Branched-Chain Amino Acid Levels Predict Deterioration of Glycemic Control in Adolescents
Tricò D, Prinsen H, Giannini C, de Graaf R, Juchem C, Li F, Caprio S, Santoro N, Herzog RI. Elevated α-Hydroxybutyrate and Branched-Chain Amino Acid Levels Predict Deterioration of Glycemic Control in Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2017, 102: 2473-2481. PMID: 28482070, PMCID: PMC5505187, DOI: 10.1210/jc.2017-00475.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmino Acids, Branched-ChainBiomarkersBlood GlucoseChildCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGlucose Tolerance TestGlycemic IndexHumansHydroxybutyratesInsulin ResistanceLinear ModelsLongitudinal StudiesMaleMultivariate AnalysisObesityPredictive Value of TestsReference ValuesRisk AssessmentConceptsOral glucose tolerance testBranched-chain amino acidsGlycemic controlInsulin resistanceΑ-hydroxybutyrateGlucose toleranceInsulin sensitivityParameters of IRBody mass index z-scoreType 2 diabetes mellitusEarly metabolic featuresChain amino acid levelsTraditional risk factorsPediatric obesity clinicGlucose tolerance testElevated baseline concentrationsIndex z-scoreType 2 diabetesReduced insulin sensitivityDiabetes mellitusObesity clinicNondiabetic adolescentsProgressive worseningDisposition indexGlucose controlMetabolic brain adaptations to recurrent hypoglycaemia may explain the link between type 1 diabetes mellitus and epilepsy and point towards future study and treatment options
Tricò D, Herzog RI. Metabolic brain adaptations to recurrent hypoglycaemia may explain the link between type 1 diabetes mellitus and epilepsy and point towards future study and treatment options. Diabetologia 2017, 60: 938-939. PMID: 28236055, PMCID: PMC5395303, DOI: 10.1007/s00125-017-4231-5.Peer-Reviewed Original ResearchConceptsType 1 diabetes mellitusDiabetes mellitusTreatment optionsBrain adaptationFuture studiesHypoglycaemiaMellitusEpilepsy
2015
Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor
Xiang Y, Cheng J, Wang D, Hu X, Xie Y, Stitham J, Atteya G, Du J, Tang WH, Lee SH, Leslie K, Spollett G, Liu Z, Herzog E, Herzog RI, Lu J, Martin KA, Hwa J. Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor. Blood 2015, 125: 3377-3387. PMID: 25814526, PMCID: PMC4447857, DOI: 10.1182/blood-2015-01-620278.Peer-Reviewed Original ResearchConceptsVon Willebrand factorDiabetes mellitusMiR-24Diabetic patientsAdverse thrombotic eventsThrombotic cardiovascular eventsVWF expressionWillebrand factorDiabetic mouse modelNovel therapeutic targetHistamine H1 receptorsEndothelial cell expressionHyperglycemia-induced activationCardiovascular eventsThrombotic eventsH1 receptorsMouse modelVWF levelsTherapeutic targetCell expressionMellitusPatientsEndothelial cellsElevated levelsReactive oxygen species