2021
Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway
Al Mamun A, Matsuzaki K, Islam R, Hossain S, Hossain ME, Katakura M, Arai H, Shido O, Hashimoto M. Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway. Neurochemical Research 2021, 47: 933-951. PMID: 34855048, DOI: 10.1007/s11064-021-03495-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzoquinonesBrain-Derived Neurotrophic FactorHippocampusNeurogenesisRatsSignal TransductionConceptsBrain-derived neurotrophic factorChronic administrationCAMP response element-binding proteinAdult ratsHippocampal neurogenesisCREB/brain-derived neurotrophic factorBDNF Signaling PathwayChronic oral administrationAdult hippocampal neurogenesisNumber of bromodeoxyuridineEffect of TQCultured neural stem/progenitor cellsMature neuronal markersNeural stem/progenitor cellsNigella sativa LinnStem/progenitor cellsProfound beneficial effectsRats ViaWestern blot analysisBDNF pathwayProportion of cellsTQ treatmentAdult neurogenesisNeurotrophic factorDentate gyrusAnredera cordifolia extract enhances learning and memory in senescence-accelerated mouse-prone 8 (SAMP8) mice
Sumiyoshi E, Hashimoto M, Hossain S, Matsuzaki K, Islam R, Tanabe Y, Maruyama K, Kajima K, Arai H, Ohizumi Y, Shido O. Anredera cordifolia extract enhances learning and memory in senescence-accelerated mouse-prone 8 (SAMP8) mice. Food & Function 2021, 12: 3992-4004. PMID: 33977955, DOI: 10.1039/d0fo03272g.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsBrain-Derived Neurotrophic FactorCREB-Binding ProteinDisks Large Homolog 4 ProteinHippocampusLearningMagnoliopsidaMaleMaze LearningMemoryMemory DisordersMiceNeuronal PlasticityPlant ExtractsConceptsBrain-derived neurotropic factorPlasticity-related proteinsBlood biochemistry parametersMemory deficitsSynaptic plasticity-related proteinsBiochemistry parametersNovel object recognition taskMorris water maze taskAC extractNoticeable side effectsWater maze taskNegative control groupAge-related memory deficitsAge-related declineHippocampal levelsNeurotropic factorOral administrationCognition declinePathological changesMouse modelSide effectsBehavioral testingNOR taskControl groupMemory impairment
2019
Theobromine Improves Working Memory by Activating the CaMKII/CREB/BDNF Pathway in Rats
Islam R, Matsuzaki K, Sumiyoshi E, Hossain E, Hashimoto M, Katakura M, Sugimoto N, Shido O. Theobromine Improves Working Memory by Activating the CaMKII/CREB/BDNF Pathway in Rats. Nutrients 2019, 11: 888. PMID: 31010016, PMCID: PMC6520707, DOI: 10.3390/nu11040888.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain-Derived Neurotrophic FactorCacaoCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP Response Element-Binding ProteinDietary SupplementsMaleMaze LearningMemory, Short-TermPhosphorylationPhytotherapyPlant ExtractsRats, WistarRNA, MessengerSignal TransductionTheobromineConceptsCREB/BDNF pathwayBrain-derived neurotropic factorMedial prefrontal cortexCAMP response element-binding proteinBDNF pathwayTB ratsCN ratsNovel object recognition testPhosphorylated cAMP response element-binding proteinY-maze testMale Wistar ratsEffect of theobromineObject recognition testRadial arm maze taskEnzyme-linked immunosorbentPrimary methylxanthineBDNF levelsBDNF proteinNeurotropic factorNormal dietReal-time PCRWistar ratsDifferent brain processesElement-binding proteinP-CaMKII
2017
Direct exposure to mild heat promotes proliferation and neuronal differentiation of neural stem/progenitor cells in vitro
Hossain E, Matsuzaki K, Katakura M, Sugimoto N, Al Mamun AA, Islam R, Hashimoto M, Shido O. Direct exposure to mild heat promotes proliferation and neuronal differentiation of neural stem/progenitor cells in vitro. PLOS ONE 2017, 12: e0190356. PMID: 29287093, PMCID: PMC5747471, DOI: 10.1371/journal.pone.0190356.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain-Derived Neurotrophic FactorCell DifferentiationCell ProliferationCells, CulturedChromonesCREB-Binding ProteinHeat-Shock ProteinsHot TemperatureMorpholinesNeural Stem CellsNeuronsPhosphorylationProto-Oncogene Proteins c-aktRatsReactive Oxygen SpeciesReal-Time Polymerase Chain ReactionConceptsNSC/NPC proliferationBrain-derived neurotrophic factorNSCs/NPCsNeural stem/progenitor cellsStem/progenitor cellsNeurosphere diameterMild heat exposureNPC proliferationMRNA expressionHeat exposureHeat shock proteinsNeuronal differentiationBDNF mRNA expressionProgenitor cellsEffective therapeutic strategyHeat-acclimated ratsCAMP response element-binding proteinResponse element-binding proteinReactive oxygen species levelsHeat acclimationAkt phosphorylation levelsForebrain cortexProportion of cellsEnhanced neurogenesisNeurotrophic factor