1994
Regulation of Parathyroid Hormone‐Related Peptide Gene Expression by Estrogen in GH4C1 Rat Pituitary Cells Has the Pattern of a Primary Response Gene
Holt E, Lu C, Dreyer B, Dannies P, Broadus A. Regulation of Parathyroid Hormone‐Related Peptide Gene Expression by Estrogen in GH4C1 Rat Pituitary Cells Has the Pattern of a Primary Response Gene. Journal Of Neurochemistry 1994, 62: 1239-1246. PMID: 8133258, DOI: 10.1046/j.1471-4159.1994.62041239.x.Peer-Reviewed Original ResearchConceptsGH4C1 rat pituitary cellsRat pituitary cellsPituitary cellsParathyroid hormone-related peptide gene expressionPTHrP mRNA expressionPrimary response geneParathyroid hormone-related peptide genePTHrP gene transcriptionPeptide gene expressionResponse genesPharmacological controlMRNA responseMRNA expressionTransient increaseGrowth factorGene transcriptionPlateau responsePeak response
1990
Prolactin and insulin are targeted to the regulated pathway in GH4C1 cells, but their storage is differentially regulated.
Reaves B, Van Itallie C, Moore H, Dannies P. Prolactin and insulin are targeted to the regulated pathway in GH4C1 cells, but their storage is differentially regulated. Endocrinology 1990, 4: 1017-26. PMID: 2284004, DOI: 10.1210/mend-4-7-1017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNAGene Expression RegulationMicePituitary NeoplasmsProinsulinProlactinRNA, MessengerTumor Cells, CulturedConceptsGH4C1 cellsEpidermal growth factorPRL synthesisGrowth factorPreferential increaseCombination of estradiolRegulated pathwayRat pituitary tumor cellsIntracellular PRLPituitary tumor cellsBasal releasePRL releaseIntracellular proinsulinSame time courseHormone treatmentPRL storageTumor cellsProinsulin immunoreactivityMRNA levelsPRLInsulinSame peak heightHormoneProinsulinTreatment
1988
Expression of messenger ribonucleic acids encoding a parathyroid hormone-like peptide in normal human and animal tissues with abnormal expression in human parathyroid adenomas.
Ikeda K, Weir E, Mangin M, Dannies P, Kinder B, Deftos L, Brown E, Broadus A. Expression of messenger ribonucleic acids encoding a parathyroid hormone-like peptide in normal human and animal tissues with abnormal expression in human parathyroid adenomas. Endocrinology 1988, 2: 1230-6. PMID: 3216862, DOI: 10.1210/mend-2-12-1230.Peer-Reviewed Original ResearchConceptsPTH-like peptideHuman parathyroid adenomasParathyroid adenomaAbnormal human parathyroid tissueHuman parathyroid tissueNumber of endocrineMedullary carcinoma cellsParathyroid hormone-like peptideExpression of mRNAAutonomous glandsHumoral hypercalcemiaParathyroid tissueHormone-like peptideAdrenal cortexRat brainNonendocrine tissuesAdrenal medullaBone marrowMessenger ribonucleic acidStomach mucosaHuman osteosarcomaOverexpression of transcriptsRat pituitaryNormal humansAbnormal expression
1987
Regulation of Prolactin Production and Cell Growth by Estradiol: Difference in Sensitivity to Estradiol Occurs at Level of Messenger Ribonucleic Acid Accumulation*
AMARA J, VAN ITALLIE C, DANNIES P. Regulation of Prolactin Production and Cell Growth by Estradiol: Difference in Sensitivity to Estradiol Occurs at Level of Messenger Ribonucleic Acid Accumulation*. Endocrinology 1987, 120: 264-271. PMID: 3780563, DOI: 10.1210/endo-120-1-264.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CycleCell LineDose-Response Relationship, DrugEstradiolEstrogensGene Expression RegulationProlactinRatsReceptors, EstrogenRNA, MessengerStructure-Activity RelationshipConceptsPRL productionMaximal stimulationGH4C1 cellsOrder of potencyMessenger ribonucleic acid accumulationBiological effectsBeta-EstradiolCell growthEstrogen concentrationsProlactin productionEthynyl estradiolFull agonistSame receptorEstradiolStimulationEstrogenPRL mRNAEffective concentrationAnalog potencyPotencyCellsRibonucleic acid accumulationMRNA