1988
TRH and BAY K 8644 synergistically stimulate prolactin release but not 45Ca2+ uptake
Pachter J, Law G, Dannies P. TRH and BAY K 8644 synergistically stimulate prolactin release but not 45Ca2+ uptake. American Journal Of Physiology 1988, 255: c633-c640. PMID: 2461093, DOI: 10.1152/ajpcell.1988.255.5.c633.Peer-Reviewed Original ResearchConceptsBay K 8644Thyrotropin-releasing hormoneProlactin secretionAngiotensin IIProlactin releaseChannel agonist Bay K 8644Agonist Bay K 8644Rat anterior pituitary cellsFluorescent indicator indo-1Anterior pituitary cellsDihydropyridine-sensitive Ca2Indicator indo-1Primary cultured cellsSecretory peaksPituitary cellsSubsequent stimulationIndo-1Transient increaseCytosolic Ca2GH4C1 cellsPrimary culturesSecretionUntreated cellsAdditional effectCultured cells
1976
A Possible Role of Cyclic AMP in Mediating the Effects of Thyrotropin-Releasing Hormone on Prolactin Release and on Prolactin and Growth Hormone Synthesis in Pituitary Cells in Culture
DANNIES P, GAUTVIK K, TASHJIAN A. A Possible Role of Cyclic AMP in Mediating the Effects of Thyrotropin-Releasing Hormone on Prolactin Release and on Prolactin and Growth Hormone Synthesis in Pituitary Cells in Culture. Endocrinology 1976, 98: 1147-1159. PMID: 177274, DOI: 10.1210/endo-98-5-1147.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneEffects of TRHProlactin releaseCyclic AMP concentrationGrowth hormone productionProlactin synthesisGH cellsGrowth hormone synthesisCyclic AMPPituitary cellsPhosphodiesterase inhibitorHormone productionHormone synthesisNM thyrotropin-releasing hormoneConcentration of TRHIntracellular cyclic AMP concentrationAMP concentrationCyclic AMP accumulationRat pituitary cellsHalf-maximal increaseDibutyryl cyclic AMPLong-term effectsAMP accumulationGrowth hormoneSerum-free medium