1992
Thyrotropin-releasing hormone-mediated Mn2+ entry in perifused rat anterior pituitary cells
Cui Z, Dannies P. Thyrotropin-releasing hormone-mediated Mn2+ entry in perifused rat anterior pituitary cells. Biochemical Journal 1992, 283: 507-513. PMID: 1575695, PMCID: PMC1131064, DOI: 10.1042/bj2830507.Peer-Reviewed Original ResearchConceptsAnterior pituitary cellsRat anterior pituitary cellsPituitary cellsMicroM dopaminePerifused anterior pituitary cellsIndo-1-loaded cellsReceptor-mediated Ca2Action of TRHContinuous TRH infusionTRH infusionCation entryIntracellular Ca2Indo-1TRHTumor promotorFree mediumG proteinsUnstimulated cellsCell typesDopamineCa2CellsLittle effectInsensitive wavelengthInfusion
1991
Ca2+ channel agonists enhance thyrotropin-releasing hormone-induced inositol phosphates and prolactin secretion
Pachter J, Law G, Dannies P. Ca2+ channel agonists enhance thyrotropin-releasing hormone-induced inositol phosphates and prolactin secretion. European Journal Of Pharmacology 1991, 195: 373-379. PMID: 1714395, DOI: 10.1016/0014-2999(91)90478-9.Peer-Reviewed Original ResearchMeSH Keywords3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAnimalsCalciumCalcium Channel AgonistsCalcium Channel BlockersCalcium RadioisotopesDihydropyridinesFemaleIn Vitro TechniquesInositol PhosphatesNimodipinePerfusionProlactinPyridinesRatsRats, Inbred StrainsReceptors, PurinergicThyrotropin-Releasing HormoneConceptsBay K 8644Basal prolactin secretionProlactin secretionChannel activator Bay K 8644Potentiation of TRHChannel antagonist nimodipineAnterior pituitary cellsAnterior pituitary tumor cellsEnhancement of basalAccumulation of inositolSDZ 202Antagonist nimodipinePituitary tumor cellsInositol polyphosphate accumulationCGP 28392Dihydropyridine Ca2Hormone secretionChannel agonistDihydropyridine agonistPituitary cellsTRHTumor cellsSecretionGH4C1 cellsPrimary cultures
1989
Ca2+ Transients Induced by Thyrotropin-Releasing Hormone Rapidly Lose Their Ability to Cause Release of Prolactin
Law G, Pachter J, Dannies P. Ca2+ Transients Induced by Thyrotropin-Releasing Hormone Rapidly Lose Their Ability to Cause Release of Prolactin. Endocrinology 1989, 3: 539-546. PMID: 2501668, DOI: 10.1210/mend-3-3-539.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCells, CulturedFemalePituitary Gland, AnteriorProlactinRatsRats, Inbred StrainsThyrotropin-Releasing HormoneConceptsPulses of TRHPRL releasePRL secretionCytosolic free calcium concentrationPost-receptor stepsRat anterior pituitary glandThyrotropin-Releasing HormoneRelease of prolactinIndicator indo-1Anterior pituitary glandFree calcium concentrationRelationship of changesContinuous administrationSustained elevationNM TRHPituitary glandIndo-1TRHFluorescent Ca2Calcium concentrationRefractory stateTransient spikeSecretionMinReleaseAbility of repetitive Ca2+ spikes to stimulate prolactin release is frequency dependent
Law G, Pachter J, Dannies P. Ability of repetitive Ca2+ spikes to stimulate prolactin release is frequency dependent. Biochemical And Biophysical Research Communications 1989, 158: 811-816. PMID: 2537637, DOI: 10.1016/0006-291x(89)92794-0.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCalciumCalcium ChannelsFemaleFluorescent DyesIndolesPituitary Gland, AnteriorPotassium ChlorideProlactinRatsRats, Inbred StrainsConceptsProlactin releaseAnterior pituitary cellsRelease of prolactinSustained elevated levelsCytosolic free Ca2Amount of prolactinSerial declinePeak Ca2Prolactin secretionPerifusion systemPituitary cellsIndo-1Fluorescent Ca2Repetitive Ca2Transient increaseFree Ca2Elevated levelsProlactinMM KClCa2CellsCoincident increaseMinutesReleaseHigh frequency
1988
Dopamine has no Effect on Thyrotropin-Releasing Hormone Mobilization of Calcium from Intracellular Stores in Rat Anterior Pituitary Cells
Law G, Pachter J, Dannies P. Dopamine has no Effect on Thyrotropin-Releasing Hormone Mobilization of Calcium from Intracellular Stores in Rat Anterior Pituitary Cells. Endocrinology 1988, 2: 966-972. PMID: 3141796, DOI: 10.1210/mend-2-10-966.Peer-Reviewed Original ResearchConceptsRat anterior pituitary cellsAnterior pituitary cellsPRL secretionPituitary cellsIntracellular Ca2Intracellular storesLow Ca2MM Ca2Inhibition of releaseDopaminergic reductionSource of Ca2PRL releaseIntracellular calciumNM TRHPerifusion systemExtracellular Ca2MicroM dopamineTRHInternal Ca2DopamineEnriched populationMM KClSecretionInositol phosphatesCa2Estrogen induces accumulation of the mitochondrial ribonucleic acid for subunit II of cytochrome oxidase in pituitary tumor cells.
Van Itallie C, Dannies P. Estrogen induces accumulation of the mitochondrial ribonucleic acid for subunit II of cytochrome oxidase in pituitary tumor cells. Endocrinology 1988, 2: 332-7. PMID: 2837664, DOI: 10.1210/mend-2-4-332.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCell DivisionDNADNA, RecombinantElectron Transport Complex IVEnzyme InductionEpidermal Growth FactorEstradiolFemaleInsulinMaleMitochondriaMolecular Sequence DataNucleic Acid HybridizationPituitary NeoplasmsProlactinRatsRats, Inbred StrainsRNA, MessengerTumor Cells, CulturedConceptsCytochrome oxidase II geneCytochrome oxidaseMitochondrial ribonucleic acidMitochondrial genomePituitary tumor cell lineEpidermal growth factorMRNA accumulationNumber of copiesTumor cell linesPituitary tumor cellsCell proliferationMRNACell linesRibonucleic acidMaximal inductionGenesGrowth factorGrowth ratePRL mRNA
1986
Antiestrogens are partial estrogen agonists for prolactin production in primary pituitary cultures
Martinez-Campos A, Amara J, Dannies P. Antiestrogens are partial estrogen agonists for prolactin production in primary pituitary cultures. Molecular And Cellular Endocrinology 1986, 48: 127-133. PMID: 3803705, DOI: 10.1016/0303-7207(86)90035-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedEstradiolEstrogen AntagonistsKineticsMalePituitary Gland, AnteriorProlactinPyrrolidinesRatsRats, Inbred StrainsTamoxifenThiophenesConceptsProlactin productionPituitary cellsMale rat anterior pituitary cellsRat anterior pituitary cellsPartial estrogen agonistNormal pituitary cellsAnterior pituitary cellsConcentrations of estradiolDose-response relationshipPrimary pituitary culturesEstrogen antagonistLY 117018Estrogen agonistM tamoxifenPartial agonistPituitary culturesEstrogen inductionTamoxifenMaximal stimulationFull antagonistM LysPrimary culturesStimulationPimozideAgonistsA possible differentiation of anterior pituitary cells in collagen gels into neurons
Martinez-Campos A, Dannies P. A possible differentiation of anterior pituitary cells in collagen gels into neurons. Cell And Tissue Research 1986, 244: 21-26. PMID: 2421915, DOI: 10.1007/bf00218377.Peer-Reviewed Original Research
1985
Comparison of patterns of prolactin release in GH4C1 cells and primary pituitary cultures
Delbeke D, Kojima I, Dannies P. Comparison of patterns of prolactin release in GH4C1 cells and primary pituitary cultures. Molecular And Cellular Endocrinology 1985, 43: 15-22. PMID: 3934015, DOI: 10.1016/0303-7207(85)90037-1.Peer-Reviewed Original ResearchStimulation of the Adenosine 3′,5′-Monophosphate and the Ca2+ Messenger Systems Together Reverse Dopaminergic Inhibition of Prolactin Release*
DELBEKE D, DANNIES P. Stimulation of the Adenosine 3′,5′-Monophosphate and the Ca2+ Messenger Systems Together Reverse Dopaminergic Inhibition of Prolactin Release*. Endocrinology 1985, 117: 439-446. PMID: 2990850, DOI: 10.1210/endo-117-2-439.Peer-Reviewed Original ResearchConceptsPRL releaseDopaminergic inhibitionAbsence of dopamineMessenger systemsRat anterior pituitary cellsPattern of releaseAnterior pituitary cellsCAMP messenger systemMin of preincubationBasal releaseProlactin releaseNM TRHPituitary cellsIntracellular Ca2Sustained phasePhorbol ester 12Cytosolic Ca2Intracellular cAMPTRHAdenylate cyclaseCAMP levelsDopamineSustained releaseLevel of releaseC-kinase activity
1984
Difference in Calcium Requirements for Forskolin-Induced Release of Prolactin from Normal Pituitary Cells and GH4C1 Cells in Culture*
DELBEKE D, SCAMMELI J, DANNIES P. Difference in Calcium Requirements for Forskolin-Induced Release of Prolactin from Normal Pituitary Cells and GH4C1 Cells in Culture*. Endocrinology 1984, 114: 1433-1440. PMID: 6323146, DOI: 10.1210/endo-114-4-1433.Peer-Reviewed Original ResearchConceptsGH4C1 cellsPRL releaseMale rat pituitary glandPrimary culturesNormal cellsNormal pituitary cellsPresence of D600Release of prolactinRat pituitary glandAddition of forskolinIntracellular cAMP concentrationPituitary tumorsFischer ratsPituitary cellsPituitary glandChannel inhibitorsTumor cellsTypes of cellsAdenylate cyclaseD600ForskolinCAMP concentrationCalcium requirementForskolin stimulationCells
1983
3COMPARISON OF THEEFFECTS OF HISTAMINE H2-RECEPTOR ANTAGONISTS ON PROLACTIN SECRETION IN THE RAT.
NETTI C, GUIDOBONO F, OLGIATI V, SIBILIA V, PECILE A, Dannies P. 3COMPARISON OF THEEFFECTS OF HISTAMINE H2-RECEPTOR ANTAGONISTS ON PROLACTIN SECRETION IN THE RAT. Endocrinology 1983, 113: 412-414. PMID: 6305638, DOI: 10.1210/endo-113-1-412.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCimetidineFuransImidazolesMaleProlactinRanitidineRatsRats, Inbred StrainsReceptors, HistamineReceptors, Histamine H2ConceptsPRL releaseHistamine H2-receptor antagonistsSignificant PRL releaseH2-receptor antagonistsCentral neural controlPRL-releasing activityHistamine H2 receptorsPRL secretionBlocking actionProlactin secretionH2 receptorsSingle bolusBlood samplesHigh doseBlocking potencyPrompt increaseBrain ventriclesNeural controlDrugsCimetidineRanitidineRatsStimulating effectPRLSecretion