2001
Acquisition of Lubrol Insolubility, a Common Step for Growth Hormone and Prolactin in the Secretory Pathway of Neuroendocrine Cells*
Lee M, Zhu Y, Chang J, Dannies P. Acquisition of Lubrol Insolubility, a Common Step for Growth Hormone and Prolactin in the Secretory Pathway of Neuroendocrine Cells*. Journal Of Biological Chemistry 2001, 276: 715-721. PMID: 11024038, DOI: 10.1074/jbc.m008530200.Peer-Reviewed Original ResearchAnimalsAnti-Bacterial AgentsBrefeldin AChloroquineCOS CellsDinitrobenzenesEndoplasmic ReticulumEpidermal Growth FactorEstradiolHuman Growth HormoneHydrogen-Ion ConcentrationInsulinMacrolidesMutationPituitary GlandPolyethylene GlycolsProlactinProtein TransportRatsSecretory VesiclesSolubilitySubstrate SpecificityTumor Cells, CulturedUltracentrifugation
2000
Accumulation of Synaptosomal-Associated Protein of 25 kDa (SNAP-25) and Other Proteins Associated with the Secretory Pathway in GH4C1 Cells Upon Treatment with Estradiol, Insulin, and Epidermal Growth Factor
Lee M, Zhu Y, Sun Z, Rhee H, Jeromin A, Roder J, Dannies P. Accumulation of Synaptosomal-Associated Protein of 25 kDa (SNAP-25) and Other Proteins Associated with the Secretory Pathway in GH4C1 Cells Upon Treatment with Estradiol, Insulin, and Epidermal Growth Factor. Endocrinology 2000, 141: 3485-3492. PMID: 10965922, DOI: 10.1210/endo.141.9.7647.Peer-Reviewed Original ResearchConceptsSecretory pathwayEpidermal growth factorSynaptotagmin IIICyclophilin BGH4C1 cellsInduction of proteinsGrowth factorGlucose-regulated protein 94Rat pituitary GH4C1 cellsSecretory granulesSynaptosomal-associated proteinMessenger RNA accumulationMembrane proteinsPituitary GH4C1 cellsSynaptosomal associated proteinRNA accumulationPlasma membraneProtein AssociatedSpecific proteinsSynaptotagmin IHormone-treated cellsSNAP-25Protein 94Secretory granule accumulationCoordinate eventAutosomal Dominant Growth Hormone (GH) Deficiency Type II: The Del32–71-GH Deletion Mutant Suppresses Secretion of Wild-Type GH
Lee M, Wajnrajch M, Kim S, Plotnick L, Wang J, Gertner J, Leibel R, Dannies P. Autosomal Dominant Growth Hormone (GH) Deficiency Type II: The Del32–71-GH Deletion Mutant Suppresses Secretion of Wild-Type GH. Endocrinology 2000, 141: 883-890. PMID: 10698162, DOI: 10.1210/endo.141.3.7380.Peer-Reviewed Original ResearchConceptsWild-type GHSecretory pathway functionNeuroendocrine cell lineGH deficiency type IISuppression of accumulationPathway functionTransient transfectionIntracellular stabilityCHO cellsAutosomal dominant formCell linesDecreased stabilityNormal allelePosttranslational effectGeneral suppressionCoexpressionProtein
1997
Editorial: A New Releasing Factor? with Biotechnology and a Little Bit of Luck
Dannies P. Editorial: A New Releasing Factor? with Biotechnology and a Little Bit of Luck. Endocrinology 1997, 138: 5085-5086. PMID: 9389485, DOI: 10.1210/endo.138.12.5710.Peer-Reviewed Original ResearchInefficient secretion of human H27A-prolactin, a mutant that does not bind Zn2+.
Sun Z, Lee M, Rhee H, Arrandale J, Dannies P. Inefficient secretion of human H27A-prolactin, a mutant that does not bind Zn2+. Endocrinology 1997, 11: 1544-51. PMID: 9280069, DOI: 10.1210/mend.11.10.0002.Peer-Reviewed Original Research
1986
Characterization of antiestrogen stimulation of cell number and prolactin production
Amara J, Dannies P. Characterization of antiestrogen stimulation of cell number and prolactin production. Molecular And Cellular Endocrinology 1986, 47: 183-189. PMID: 3758472, DOI: 10.1016/0303-7207(86)90111-5.Peer-Reviewed Original Research
1985
Cysteamine Causes Reduction of Prolactin Monomers Followed by Aggregation in the Rat Pituitary Gland*
SCAMMELL J, BURRAGE T, EISENFELD A, DANNIES P. Cysteamine Causes Reduction of Prolactin Monomers Followed by Aggregation in the Rat Pituitary Gland*. Endocrinology 1985, 116: 2347-2354. PMID: 3996317, DOI: 10.1210/endo-116-6-2347.Peer-Reviewed Original Research
1984
Spiperone: evidence for uptake into secretory granules.
Dannies P, Rudnick M, Fishkes H, Rudnick G. Spiperone: evidence for uptake into secretory granules. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 1867-1870. PMID: 6584920, PMCID: PMC345023, DOI: 10.1073/pnas.81.6.1867.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportButyrophenonesCells, CulturedCytoplasmic GranulesKineticsPituitary GlandRatsSpiperoneConceptsSerotonin receptorsSecretory granulesRat pituitary tumor cellsMicroM reserpinePlatelet dense granulesPituitary tumor cellsDopamine antagonistsIntracellular storage organellesSpiperoneTumor cellsSerotonin transportDense granulesBiogenic amine transportReceptorsCell strainsDopamineEquimolar concentrationsSpecific ligandsAmine transportStorage organellesPlasma membrane transport systemsReserpineAntagonistMinNeurons
1983
Synthesis and biological activity of 5-fluoroimidazole-TRH
Labroo V, Kirk K, Cohen L, Delbeke D, Dannies P. Synthesis and biological activity of 5-fluoroimidazole-TRH. Biochemical And Biophysical Research Communications 1983, 113: 581-585. PMID: 6409106, DOI: 10.1016/0006-291x(83)91765-5.Peer-Reviewed Original Research
1982
Histidyl-proline diketopiperazine: its biological role as a regulatory peptide
Peterkofsky A, Battaini F, Koch Y, Takahara Y, Dannies P. Histidyl-proline diketopiperazine: its biological role as a regulatory peptide. Molecular And Cellular Biochemistry 1982, 42: 45-63. PMID: 6278283, DOI: 10.1007/bf00223538.Peer-Reviewed Original ResearchConceptsHistidyl-proline diketopiperazineCentral nervous systemAdrenal cortex membranesCyclic nucleotide levelsCNS depressionSpecific membrane receptorsCortex membranesProlactin releaseRat brainClassical neurotransmittersNervous systemPituitary cellsTRHSuch receptorsRegulatory peptidesPituitaryStereotypic behaviorImmunological methodsSpecific bindingBrainMembrane receptorsReceptorsDistribution studiesPossible mechanismNucleotide level
1980
Action of Cholera Toxin on Hormone Synthesis and Release in GH Cells: Evidence that Adenosine 3′,5′-Monophosphate Does Not Mediate the Decrease in Growth Hormone Synthesis Caused by Thyrotropin-Releasing Hormone*
DANNIES P, TASHJIAN A. Action of Cholera Toxin on Hormone Synthesis and Release in GH Cells: Evidence that Adenosine 3′,5′-Monophosphate Does Not Mediate the Decrease in Growth Hormone Synthesis Caused by Thyrotropin-Releasing Hormone*. Endocrinology 1980, 106: 1532-1536. PMID: 6244936, DOI: 10.1210/endo-106-5-1532.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCholera ToxinCyclic AMPGrowth HormoneKineticsPituitary GlandProlactinRatsThyrotropin-Releasing HormoneConceptsGH synthesisCholera toxinIntracellular cAMPWeeks of treatmentThyrotropin-releasing hormoneRelease of PRLHormone synthesisRat pituitary cellsIntracellular PRLGrowth hormone synthesisPRL releaseSimilar lag periodPituitary cellsGH cellsControl valuesPRL synthesisTRHPRLToxinClonal strainsLag periodReleaseCellsCAMPDecrease
1977
Anti-Estrogenic Compounds Increase Prolactin and Growth Hormone Synthesis in Clonal Strains of Rat Pituitary Cells1
DANNIES P, YEN P, TASHJIAN A. Anti-Estrogenic Compounds Increase Prolactin and Growth Hormone Synthesis in Clonal Strains of Rat Pituitary Cells1. Endocrinology 1977, 101: 1151-1156. PMID: 908269, DOI: 10.1210/endo-101-4-1151.Peer-Reviewed Original Research
1976
Release and synthesis of prolactin by rat pituitary cell strains are regulated independently by thyrotropin-releasing hormone
DANNIES P, TASJIAN A. Release and synthesis of prolactin by rat pituitary cell strains are regulated independently by thyrotropin-releasing hormone. Nature 1976, 261: 707-710. PMID: 180421, DOI: 10.1038/261707a0.Peer-Reviewed Original ResearchA Possible Role of Cyclic AMP in Mediating the Effects of Thyrotropin-Releasing Hormone on Prolactin Release and on Prolactin and Growth Hormone Synthesis in Pituitary Cells in Culture
DANNIES P, GAUTVIK K, TASHJIAN A. A Possible Role of Cyclic AMP in Mediating the Effects of Thyrotropin-Releasing Hormone on Prolactin Release and on Prolactin and Growth Hormone Synthesis in Pituitary Cells in Culture. Endocrinology 1976, 98: 1147-1159. PMID: 177274, DOI: 10.1210/endo-98-5-1147.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneEffects of TRHProlactin releaseCyclic AMP concentrationGrowth hormone productionProlactin synthesisGH cellsGrowth hormone synthesisCyclic AMPPituitary cellsPhosphodiesterase inhibitorHormone productionHormone synthesisNM thyrotropin-releasing hormoneConcentration of TRHIntracellular cyclic AMP concentrationAMP concentrationCyclic AMP accumulationRat pituitary cellsHalf-maximal increaseDibutyryl cyclic AMPLong-term effectsAMP accumulationGrowth hormoneSerum-free medium
1974
Pyroglutamyl-histidyl-prolineamide (TRH). A neurohormone which affects the release and synthesis of prolactin and thyrotropin.
Dannies P, Tashjian A. Pyroglutamyl-histidyl-prolineamide (TRH). A neurohormone which affects the release and synthesis of prolactin and thyrotropin. Israel Medical Association Journal 1974, 10: 1294-304. PMID: 4215776.Peer-Reviewed Original Research
1973
Effects of Thyrotropin-releasing Hormone and Hydrocortisone on Synthesis and Degradation of Prolactin in a Rat Pituitary Cell Strain
Dannies P, Tashjian A. Effects of Thyrotropin-releasing Hormone and Hydrocortisone on Synthesis and Degradation of Prolactin in a Rat Pituitary Cell Strain. Journal Of Biological Chemistry 1973, 248: 6174-6179. PMID: 4199262, DOI: 10.1016/s0021-9258(19)43524-2.Peer-Reviewed Original ResearchConceptsSynthesis of prolactinProlactin accumulationThyrotropin-releasing hormoneHydrocortisone resultsEffect of thyrotropinLong-term effectsPituitary cellsGH cellsProlactinDegradation of prolactinHormoneTerm effectsHydrocortisoneIntracellular poolDecreased accumulationClonal strainsCell strainsRadioactive leucineSpecific immunoprecipitationCellsHoursTreatmentDaysLeucineCulture medium