1991
Ca2+ channel agonists enhance thyrotropin-releasing hormone-induced inositol phosphates and prolactin secretion
Pachter J, Law G, Dannies P. Ca2+ channel agonists enhance thyrotropin-releasing hormone-induced inositol phosphates and prolactin secretion. European Journal Of Pharmacology 1991, 195: 373-379. PMID: 1714395, DOI: 10.1016/0014-2999(91)90478-9.Peer-Reviewed Original ResearchMeSH Keywords3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAnimalsCalciumCalcium Channel AgonistsCalcium Channel BlockersCalcium RadioisotopesDihydropyridinesFemaleIn Vitro TechniquesInositol PhosphatesNimodipinePerfusionProlactinPyridinesRatsRats, Inbred StrainsReceptors, PurinergicThyrotropin-Releasing HormoneConceptsBay K 8644Basal prolactin secretionProlactin secretionChannel activator Bay K 8644Potentiation of TRHChannel antagonist nimodipineAnterior pituitary cellsAnterior pituitary tumor cellsEnhancement of basalAccumulation of inositolSDZ 202Antagonist nimodipinePituitary tumor cellsInositol polyphosphate accumulationCGP 28392Dihydropyridine Ca2Hormone secretionChannel agonistDihydropyridine agonistPituitary cellsTRHTumor cellsSecretionGH4C1 cellsPrimary cultures
1988
TRH and BAY K 8644 synergistically stimulate prolactin release but not 45Ca2+ uptake
Pachter J, Law G, Dannies P. TRH and BAY K 8644 synergistically stimulate prolactin release but not 45Ca2+ uptake. American Journal Of Physiology 1988, 255: c633-c640. PMID: 2461093, DOI: 10.1152/ajpcell.1988.255.5.c633.Peer-Reviewed Original ResearchConceptsBay K 8644Thyrotropin-releasing hormoneProlactin secretionAngiotensin IIProlactin releaseChannel agonist Bay K 8644Agonist Bay K 8644Rat anterior pituitary cellsFluorescent indicator indo-1Anterior pituitary cellsDihydropyridine-sensitive Ca2Indicator indo-1Primary cultured cellsSecretory peaksPituitary cellsSubsequent stimulationIndo-1Transient increaseCytosolic Ca2GH4C1 cellsPrimary culturesSecretionUntreated cellsAdditional effectCultured cells
1986
Antiestrogens are partial estrogen agonists for prolactin production in primary pituitary cultures
Martinez-Campos A, Amara J, Dannies P. Antiestrogens are partial estrogen agonists for prolactin production in primary pituitary cultures. Molecular And Cellular Endocrinology 1986, 48: 127-133. PMID: 3803705, DOI: 10.1016/0303-7207(86)90035-3.Peer-Reviewed Original ResearchConceptsProlactin productionPituitary cellsMale rat anterior pituitary cellsRat anterior pituitary cellsPartial estrogen agonistNormal pituitary cellsAnterior pituitary cellsConcentrations of estradiolDose-response relationshipPrimary pituitary culturesEstrogen antagonistLY 117018Estrogen agonistM tamoxifenPartial agonistPituitary culturesEstrogen inductionTamoxifenMaximal stimulationFull antagonistM LysPrimary culturesStimulationPimozideAgonistsDopamine Inhibits Prolactin Release when Cyclic Adenosine 3′,5′-Monophosphate Levels Are Elevated*
DELBEKE P, SCAMMELL J, MARTINEZ-CAMPOS A, DANNIES P. Dopamine Inhibits Prolactin Release when Cyclic Adenosine 3′,5′-Monophosphate Levels Are Elevated*. Endocrinology 1986, 118: 1271-1277. PMID: 3004906, DOI: 10.1210/endo-118-4-1271.Peer-Reviewed Original ResearchConceptsPRL releaseIntracellular cAMP concentrationFemale Fischer 344 ratsCAMP levelsAnterior pituitary cellsCAMP concentrationFischer 344 ratsPRL accumulationPercentage of lactotrophsDopamine inhibitsPituitary tumorsContinuous Percoll density gradientsNM TRHPituitary cellsCAMP accumulationMicroM dopaminePercoll density gradientsBasal levelsMonophosphate levelsMin of incubationLactotrophsAdenylate cyclasePrimary culturesDopamineForskolin
1985
Comparison of patterns of prolactin release in GH4C1 cells and primary pituitary cultures
Delbeke D, Kojima I, Dannies P. Comparison of patterns of prolactin release in GH4C1 cells and primary pituitary cultures. Molecular And Cellular Endocrinology 1985, 43: 15-22. PMID: 3934015, DOI: 10.1016/0303-7207(85)90037-1.Peer-Reviewed Original Research
1984
Difference in Calcium Requirements for Forskolin-Induced Release of Prolactin from Normal Pituitary Cells and GH4C1 Cells in Culture*
DELBEKE D, SCAMMELI J, DANNIES P. Difference in Calcium Requirements for Forskolin-Induced Release of Prolactin from Normal Pituitary Cells and GH4C1 Cells in Culture*. Endocrinology 1984, 114: 1433-1440. PMID: 6323146, DOI: 10.1210/endo-114-4-1433.Peer-Reviewed Original ResearchConceptsGH4C1 cellsPRL releaseMale rat pituitary glandPrimary culturesNormal cellsNormal pituitary cellsPresence of D600Release of prolactinRat pituitary glandAddition of forskolinIntracellular cAMP concentrationPituitary tumorsFischer ratsPituitary cellsPituitary glandChannel inhibitorsTumor cellsTypes of cellsAdenylate cyclaseD600ForskolinCAMP concentrationCalcium requirementForskolin stimulationCellsDepletion of Pituitary Prolactin by Cysteamine Is due to Loss of Immunological Activity*
SCAMMELL J, DANNIES P. Depletion of Pituitary Prolactin by Cysteamine Is due to Loss of Immunological Activity*. Endocrinology 1984, 114: 712-716. PMID: 6697959, DOI: 10.1210/endo-114-3-712.Peer-Reviewed Original Research
1983
Veratridine and Ouabain Stimulate Calcium-Dependent Prolactin Release*
SCAMMELL J, DANNIES P. Veratridine and Ouabain Stimulate Calcium-Dependent Prolactin Release*. Endocrinology 1983, 113: 1228-1235. PMID: 6617570, DOI: 10.1210/endo-113-4-1228.Peer-Reviewed Original ResearchConceptsPRL releaseCalcium channel blocker D600Rat anterior pituitary cellsTetrodotoxin-insensitive mechanismCalcium channel blockersChannel blocker tetrodotoxinDopaminergic agonist bromocriptineEffect of veratridineAnterior pituitary cellsAction of veratridineChannel blocker D600Blocker tetrodotoxinAgonist bromocriptineProlactin releaseChannel blockersVeratridine effectPituitary cellsChannel activatorVeratridineGH4C1 cellsPrimary culturesOuabainNormal cellsStimulationPreincubation
1980
2-Bromo-alpha-ergocryptine causes degradation of prolactin in primary cultures of rat pituitary cells after chronic treatment.
Dannies P, Rudnick M. 2-Bromo-alpha-ergocryptine causes degradation of prolactin in primary cultures of rat pituitary cells after chronic treatment. Journal Of Biological Chemistry 1980, 255: 2776-2781. PMID: 7358708, DOI: 10.1016/s0021-9258(19)85806-4.Peer-Reviewed Original Research