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Peter Peduzzi, PhD

Professor Emeritus of Biostatistics and Senior Research Scientist of Biostatistics
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About

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Professor Emeritus of Biostatistics and Senior Research Scientist of Biostatistics

Biography

Peter is professor of biostatistics at YSPH and director of the Yale Center for Analytical Sciences (YCAS) and the Yale Data Coordinating Center. Dr. Peduzzi has nearly 40 years’ experience in the design, conduct and analysis of clinical trials with a particular focus on pragmatic trials. He is the PI of several data coordinating centers funded by NIH and PCORI. Before coming to Yale he was the Director of the Department of Veterans Affairs (VA) Cooperative Studies Program Coordinating Center in West Haven, Connecticut, which conducts multi-center, multi-national clinical trials and epidemiologic studies. He still maintains an affiliation with this center. His primary research interests have focused on the efficient design and analysis of clinical trials, with a recent focus on clustered randomized trials.

Appointments

Education & Training

PhD
Yale University (1976)

Research

Overview

A major area of current research focus is on the design and analysis of complex clustered randomized clinical trials with time to event outcomes in the presence of a semi-competing risk of death. In particular, we are investigating the estimation of the cluster design effect for these types of complex designs, which has implications for sample size, interim monitoring and power. Because there are no closed form estimates for the design effect, approaches being considered are centered on variance inflation factors and simulation studies. Recently completed work on the analysis of complex cluster randomized trials has focused on the development of a joint model for recurrent events and a semi-competing risk in the presence of multi-level clustering. Future research in this area will include extensions to different types of recurrent events. Another area of current research activity involves patient preference clinical trial designs. Methods have been developed for binary outcomes and future work will include time to event outcomes. This work is being funded by a PCORI methods grant. Plans are in progress to hold a symposium on the design and analysis of patient preference clinical trials involving methodologists and clinical investigators, e.g., those involved in palliative care and end of life research. Past methods work has been in the area of hybrid Bayesian-frequentist designs. In particular, selection of the effect size for sample size determination for a continuous response in a superiority clinical trial using a hybrid classical and Bayesian procedure.

Medical Subject Headings (MeSH)

Aging; Biostatistics; Clinical Trials as Topic; Patient Preference; Pragmatic Clinical Trials as Topic

Research at a Glance

Yale Co-Authors

Frequent collaborators of Peter Peduzzi's published research.

Publications

2024

2023

Academic Achievements & Community Involvement

  • activity

    Antiretrovirals, Options in Management (OPTIMA)

  • activity

    Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluations (COURAGE)

  • honor

    Fellow, Council on Epidemiology, American Heart Association

  • honor

    Fellow, American Statistical Association

  • honor

    Past President, Society for Clinical Trials

Get In Touch

Contacts

Academic Office Number
Office Fax Number

Locations

  • 300 George Street

    Academic Office

    Ste Suite 511

    New Haven, CT 06511